Interactions between Cytokines, Congenital Anomalies of Kidney and Urinary Tract and Chronic Kidney Disease
Fetal hydronephrosis is the most common anomaly detected on antenatal ultrasound, affecting 1–5% of pregnancies. Postnatal investigation has the major aim in detecting infants with severe urinary tract obstruction and clinically significant urinary tract anomalies among the heterogeneous universe of...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/597920 |
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| author | Ana Cristina Simões e Silva Flávia Cordeiro Valério Mariana Affonso Vasconcelos Débora Marques Miranda Eduardo Araújo Oliveira |
| author_facet | Ana Cristina Simões e Silva Flávia Cordeiro Valério Mariana Affonso Vasconcelos Débora Marques Miranda Eduardo Araújo Oliveira |
| author_sort | Ana Cristina Simões e Silva |
| collection | DOAJ |
| description | Fetal hydronephrosis is the most common anomaly detected on antenatal ultrasound, affecting 1–5% of pregnancies. Postnatal investigation has the major aim in detecting infants with severe urinary tract obstruction and clinically significant urinary tract anomalies among the heterogeneous universe of patients. Congenital uropathies are frequent causes of pediatric chronic kidney disease (CKD). Imaging techniques clearly contribute to this purpose; however, sometimes, these exams are invasive, very expensive, and not sufficient to precisely define the best approach as well as the prognosis. Recently, biomarkers have become a focus of clinical research as potentially useful diagnostic tools in pediatric urological diseases. In this regard, recent studies suggest a role for cytokines and chemokines in the pathophysiology of CAKUT and for the progression to CKD. Some authors proposed that the evaluation of these inflammatory mediators might help the management of postnatal uropathies and the detection of patients with high risk to developed chronic kidney disease. Therefore, the aim of this paper is to revise general aspects of cytokines and the link between cytokines, CAKUT, and CKD by including experimental and clinical evidence. |
| format | Article |
| id | doaj-art-4bc69beb491d42b8b3d288450339713c |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-4bc69beb491d42b8b3d288450339713c2025-02-03T05:55:18ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/597920597920Interactions between Cytokines, Congenital Anomalies of Kidney and Urinary Tract and Chronic Kidney DiseaseAna Cristina Simões e Silva0Flávia Cordeiro Valério1Mariana Affonso Vasconcelos2Débora Marques Miranda3Eduardo Araújo Oliveira4Pediatric Nephrology Unit, Department of Pediatrics, Federal University of Minas Gerais (UFMG), 30130-100 Belo Horizonte, MG, BrazilPediatric Nephrology Unit, Department of Pediatrics, Federal University of Minas Gerais (UFMG), 30130-100 Belo Horizonte, MG, BrazilPediatric Nephrology Unit, Department of Pediatrics, Federal University of Minas Gerais (UFMG), 30130-100 Belo Horizonte, MG, BrazilPediatric Nephrology Unit, Department of Pediatrics, Federal University of Minas Gerais (UFMG), 30130-100 Belo Horizonte, MG, BrazilPediatric Nephrology Unit, Department of Pediatrics, Federal University of Minas Gerais (UFMG), 30130-100 Belo Horizonte, MG, BrazilFetal hydronephrosis is the most common anomaly detected on antenatal ultrasound, affecting 1–5% of pregnancies. Postnatal investigation has the major aim in detecting infants with severe urinary tract obstruction and clinically significant urinary tract anomalies among the heterogeneous universe of patients. Congenital uropathies are frequent causes of pediatric chronic kidney disease (CKD). Imaging techniques clearly contribute to this purpose; however, sometimes, these exams are invasive, very expensive, and not sufficient to precisely define the best approach as well as the prognosis. Recently, biomarkers have become a focus of clinical research as potentially useful diagnostic tools in pediatric urological diseases. In this regard, recent studies suggest a role for cytokines and chemokines in the pathophysiology of CAKUT and for the progression to CKD. Some authors proposed that the evaluation of these inflammatory mediators might help the management of postnatal uropathies and the detection of patients with high risk to developed chronic kidney disease. Therefore, the aim of this paper is to revise general aspects of cytokines and the link between cytokines, CAKUT, and CKD by including experimental and clinical evidence.http://dx.doi.org/10.1155/2013/597920 |
| spellingShingle | Ana Cristina Simões e Silva Flávia Cordeiro Valério Mariana Affonso Vasconcelos Débora Marques Miranda Eduardo Araújo Oliveira Interactions between Cytokines, Congenital Anomalies of Kidney and Urinary Tract and Chronic Kidney Disease Clinical and Developmental Immunology |
| title | Interactions between Cytokines, Congenital Anomalies of Kidney and Urinary Tract and Chronic Kidney Disease |
| title_full | Interactions between Cytokines, Congenital Anomalies of Kidney and Urinary Tract and Chronic Kidney Disease |
| title_fullStr | Interactions between Cytokines, Congenital Anomalies of Kidney and Urinary Tract and Chronic Kidney Disease |
| title_full_unstemmed | Interactions between Cytokines, Congenital Anomalies of Kidney and Urinary Tract and Chronic Kidney Disease |
| title_short | Interactions between Cytokines, Congenital Anomalies of Kidney and Urinary Tract and Chronic Kidney Disease |
| title_sort | interactions between cytokines congenital anomalies of kidney and urinary tract and chronic kidney disease |
| url | http://dx.doi.org/10.1155/2013/597920 |
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