Immune Checkpoint Inhibitor-Induced Limbic Encephalitis during Treatment with Atezolizumab in a Patient with Small-Cell Lung Cancer: A Case Report and Review of the Literature
Paraneoplastic neurological syndrome (PNS) is associated with malignancies, including small-cell lung cancer. Recently, PNS cases among patients with small-cell lung cancer (SCLC) induced by immune checkpoint inhibitors have increased. We herein report a 66-year-old man with SCLC who developed disor...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Immunology |
| Online Access: | http://dx.doi.org/10.1155/2022/9290922 |
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| _version_ | 1832559133758324736 |
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| author | Koki Nakashima Yoshiki Demura Kosuke Kurokawa Toshihiro Takeda Norihiro Jikuya Masahiro Oi Toshihiko Tada Masaya Akai Tamotsu Ishizuka |
| author_facet | Koki Nakashima Yoshiki Demura Kosuke Kurokawa Toshihiro Takeda Norihiro Jikuya Masahiro Oi Toshihiko Tada Masaya Akai Tamotsu Ishizuka |
| author_sort | Koki Nakashima |
| collection | DOAJ |
| description | Paraneoplastic neurological syndrome (PNS) is associated with malignancies, including small-cell lung cancer. Recently, PNS cases among patients with small-cell lung cancer (SCLC) induced by immune checkpoint inhibitors have increased. We herein report a 66-year-old man with SCLC who developed disorientation, dysphagia, and gait disturbance after three courses of treatment with atezolizumab. Brain magnetic resonance imaging revealed a high-intensity area in the bilateral temporal lobes. Blood test results were positive for anti-Hu and anti-Zic4 antibodies, which led to the diagnosis of limbic encephalitis as PNS. Some symptoms improved with intravenous administration of steroids and immunoglobulins. |
| format | Article |
| id | doaj-art-4bbaf35b4b784f888a049fea14c3ecd0 |
| institution | Kabale University |
| issn | 2090-6617 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Immunology |
| spelling | doaj-art-4bbaf35b4b784f888a049fea14c3ecd02025-02-03T01:30:39ZengWileyCase Reports in Immunology2090-66172022-01-01202210.1155/2022/9290922Immune Checkpoint Inhibitor-Induced Limbic Encephalitis during Treatment with Atezolizumab in a Patient with Small-Cell Lung Cancer: A Case Report and Review of the LiteratureKoki Nakashima0Yoshiki Demura1Kosuke Kurokawa2Toshihiro Takeda3Norihiro Jikuya4Masahiro Oi5Toshihiko Tada6Masaya Akai7Tamotsu Ishizuka8Depertment of Respiratory MedicineDepertment of Respiratory MedicineDepertment of Respiratory MedicineDepertment of Respiratory MedicineDepertment of Respiratory MedicineDepertment of Respiratory MedicineDepertment of Respiratory MedicineDepertment of Respiratory MedicineThird Department of Internal MedicineParaneoplastic neurological syndrome (PNS) is associated with malignancies, including small-cell lung cancer. Recently, PNS cases among patients with small-cell lung cancer (SCLC) induced by immune checkpoint inhibitors have increased. We herein report a 66-year-old man with SCLC who developed disorientation, dysphagia, and gait disturbance after three courses of treatment with atezolizumab. Brain magnetic resonance imaging revealed a high-intensity area in the bilateral temporal lobes. Blood test results were positive for anti-Hu and anti-Zic4 antibodies, which led to the diagnosis of limbic encephalitis as PNS. Some symptoms improved with intravenous administration of steroids and immunoglobulins.http://dx.doi.org/10.1155/2022/9290922 |
| spellingShingle | Koki Nakashima Yoshiki Demura Kosuke Kurokawa Toshihiro Takeda Norihiro Jikuya Masahiro Oi Toshihiko Tada Masaya Akai Tamotsu Ishizuka Immune Checkpoint Inhibitor-Induced Limbic Encephalitis during Treatment with Atezolizumab in a Patient with Small-Cell Lung Cancer: A Case Report and Review of the Literature Case Reports in Immunology |
| title | Immune Checkpoint Inhibitor-Induced Limbic Encephalitis during Treatment with Atezolizumab in a Patient with Small-Cell Lung Cancer: A Case Report and Review of the Literature |
| title_full | Immune Checkpoint Inhibitor-Induced Limbic Encephalitis during Treatment with Atezolizumab in a Patient with Small-Cell Lung Cancer: A Case Report and Review of the Literature |
| title_fullStr | Immune Checkpoint Inhibitor-Induced Limbic Encephalitis during Treatment with Atezolizumab in a Patient with Small-Cell Lung Cancer: A Case Report and Review of the Literature |
| title_full_unstemmed | Immune Checkpoint Inhibitor-Induced Limbic Encephalitis during Treatment with Atezolizumab in a Patient with Small-Cell Lung Cancer: A Case Report and Review of the Literature |
| title_short | Immune Checkpoint Inhibitor-Induced Limbic Encephalitis during Treatment with Atezolizumab in a Patient with Small-Cell Lung Cancer: A Case Report and Review of the Literature |
| title_sort | immune checkpoint inhibitor induced limbic encephalitis during treatment with atezolizumab in a patient with small cell lung cancer a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2022/9290922 |
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