Glial Cells of the Central Nervous System: A Potential Target in Chronic Prostatitis/Chronic Pelvic Pain Syndrome
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is one of the most common diseases of the male urological system while the etiology and treatment of CP/CPPS remain a thorny issue. Cumulative research suggested a potentially important role of glial cells in CP/CPPS. This narrative review r...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
|
| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2023/2061632 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832559689275015168 |
|---|---|
| author | Yongfeng Lao Zewen Li Yanan Bai Weijia Li Jian Wang Yanan Wang Qingchao Li Zhilong Dong |
| author_facet | Yongfeng Lao Zewen Li Yanan Bai Weijia Li Jian Wang Yanan Wang Qingchao Li Zhilong Dong |
| author_sort | Yongfeng Lao |
| collection | DOAJ |
| description | Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is one of the most common diseases of the male urological system while the etiology and treatment of CP/CPPS remain a thorny issue. Cumulative research suggested a potentially important role of glial cells in CP/CPPS. This narrative review retrospected literature and grasped the research process about glial cells and CP/CPPS. Three types of glial cells showed a crucial connection with general pain and psychosocial symptoms. Microglia might also be involved in lower urinary tract symptoms. Only microglia and astrocytes have been studied in the animal model of CP/CPPS. Activated microglia and reactive astrocytes were found to be involved in both pain and psychosocial symptoms of CP/CPPS. The possible mechanism might be to mediate the production of some inflammatory mediators and their interaction with neurons. Glial cells provide a new insight to understand the cause of complex symptoms of CP/CPPS and might become a novel target to develop new treatment options. However, the activation and action mechanism of glial cells in CP/CPPS needs to be further explored. |
| format | Article |
| id | doaj-art-4b8dc0b1de6a494faef4dcf578259056 |
| institution | Kabale University |
| issn | 1918-1523 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pain Research and Management |
| spelling | doaj-art-4b8dc0b1de6a494faef4dcf5782590562025-02-03T01:29:24ZengWileyPain Research and Management1918-15232023-01-01202310.1155/2023/2061632Glial Cells of the Central Nervous System: A Potential Target in Chronic Prostatitis/Chronic Pelvic Pain SyndromeYongfeng Lao0Zewen Li1Yanan Bai2Weijia Li3Jian Wang4Yanan Wang5Qingchao Li6Zhilong Dong7Second Clinical Medical CollegeSecond Clinical Medical CollegeSecond Clinical Medical CollegeSecond Clinical Medical CollegeSecond Clinical Medical CollegeSecond Clinical Medical CollegeSecond Clinical Medical CollegeSecond Clinical Medical CollegeChronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is one of the most common diseases of the male urological system while the etiology and treatment of CP/CPPS remain a thorny issue. Cumulative research suggested a potentially important role of glial cells in CP/CPPS. This narrative review retrospected literature and grasped the research process about glial cells and CP/CPPS. Three types of glial cells showed a crucial connection with general pain and psychosocial symptoms. Microglia might also be involved in lower urinary tract symptoms. Only microglia and astrocytes have been studied in the animal model of CP/CPPS. Activated microglia and reactive astrocytes were found to be involved in both pain and psychosocial symptoms of CP/CPPS. The possible mechanism might be to mediate the production of some inflammatory mediators and their interaction with neurons. Glial cells provide a new insight to understand the cause of complex symptoms of CP/CPPS and might become a novel target to develop new treatment options. However, the activation and action mechanism of glial cells in CP/CPPS needs to be further explored.http://dx.doi.org/10.1155/2023/2061632 |
| spellingShingle | Yongfeng Lao Zewen Li Yanan Bai Weijia Li Jian Wang Yanan Wang Qingchao Li Zhilong Dong Glial Cells of the Central Nervous System: A Potential Target in Chronic Prostatitis/Chronic Pelvic Pain Syndrome Pain Research and Management |
| title | Glial Cells of the Central Nervous System: A Potential Target in Chronic Prostatitis/Chronic Pelvic Pain Syndrome |
| title_full | Glial Cells of the Central Nervous System: A Potential Target in Chronic Prostatitis/Chronic Pelvic Pain Syndrome |
| title_fullStr | Glial Cells of the Central Nervous System: A Potential Target in Chronic Prostatitis/Chronic Pelvic Pain Syndrome |
| title_full_unstemmed | Glial Cells of the Central Nervous System: A Potential Target in Chronic Prostatitis/Chronic Pelvic Pain Syndrome |
| title_short | Glial Cells of the Central Nervous System: A Potential Target in Chronic Prostatitis/Chronic Pelvic Pain Syndrome |
| title_sort | glial cells of the central nervous system a potential target in chronic prostatitis chronic pelvic pain syndrome |
| url | http://dx.doi.org/10.1155/2023/2061632 |
| work_keys_str_mv | AT yongfenglao glialcellsofthecentralnervoussystemapotentialtargetinchronicprostatitischronicpelvicpainsyndrome AT zewenli glialcellsofthecentralnervoussystemapotentialtargetinchronicprostatitischronicpelvicpainsyndrome AT yananbai glialcellsofthecentralnervoussystemapotentialtargetinchronicprostatitischronicpelvicpainsyndrome AT weijiali glialcellsofthecentralnervoussystemapotentialtargetinchronicprostatitischronicpelvicpainsyndrome AT jianwang glialcellsofthecentralnervoussystemapotentialtargetinchronicprostatitischronicpelvicpainsyndrome AT yananwang glialcellsofthecentralnervoussystemapotentialtargetinchronicprostatitischronicpelvicpainsyndrome AT qingchaoli glialcellsofthecentralnervoussystemapotentialtargetinchronicprostatitischronicpelvicpainsyndrome AT zhilongdong glialcellsofthecentralnervoussystemapotentialtargetinchronicprostatitischronicpelvicpainsyndrome |