Predisposing Factors, Microbial Characteristics, and Clinical Outcome of Microbial Keratitis in a Tertiary Centre in Hong Kong: A 10-Year Experience
Purpose. To study the risk factors, microbial profile, antibiotic susceptibility pattern, and outcome for microbial keratitis over the past 10 years in a tertiary center in Hong Kong. Methods. All cases with corneal scraping performed in Queen Mary Hospital, Hong Kong from January 2004 to December 2...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2015/769436 |
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| author | Alex Lap-Ki Ng Kelvin Kai-Wang To Chile Chi-Lai Choi Leonard Hsu Yuen Suk-Ming Yim Keith Shun-Kit Chan Jimmy Shiu-Ming Lai Ian Yat-Hin Wong |
| author_facet | Alex Lap-Ki Ng Kelvin Kai-Wang To Chile Chi-Lai Choi Leonard Hsu Yuen Suk-Ming Yim Keith Shun-Kit Chan Jimmy Shiu-Ming Lai Ian Yat-Hin Wong |
| author_sort | Alex Lap-Ki Ng |
| collection | DOAJ |
| description | Purpose. To study the risk factors, microbial profile, antibiotic susceptibility pattern, and outcome for microbial keratitis over the past 10 years in a tertiary center in Hong Kong. Methods. All cases with corneal scraping performed in Queen Mary Hospital, Hong Kong from January 2004 to December 2013 were included. Clinical outcome was defined as poor if the final visual acuity (VA) was abnormal or worse than presenting VA, a major complication occurred, or therapeutic keratoplasty was required. Results. 347 scrapes were performed in the 10-year period growing 130 microorganisms (32.3% culture positive rate). Contact lens use was the commonest risk factor. The commonest isolates were coagulase-negative Staphylococcus and Pseudomonas aeruginosa. Fluoroquinolone susceptibility was tested in 47 Gram-negative bacteria with 93.6% susceptibility (100% for Pseudomonas). 90.7% of cases had good visual outcome. Multivariate logistic regression showed age (p=0.03), trauma (p=0.006), and ulcer size >3 mm (p=0.039) to be independently associated with poor outcome. Conclusion. There was no shifting trend in the isolate distribution or emergence of resistant strains in our study. Contact lens wear was the commonest risk factor, with Pseudomonas being the most frequent isolate in this group. It remained 100% susceptible to fluoroquinolones and 97% cases had good visual outcome. |
| format | Article |
| id | doaj-art-4b7e54eef8524ad79a374cd551f249fd |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-4b7e54eef8524ad79a374cd551f249fd2025-02-03T01:09:26ZengWileyJournal of Ophthalmology2090-004X2090-00582015-01-01201510.1155/2015/769436769436Predisposing Factors, Microbial Characteristics, and Clinical Outcome of Microbial Keratitis in a Tertiary Centre in Hong Kong: A 10-Year ExperienceAlex Lap-Ki Ng0Kelvin Kai-Wang To1Chile Chi-Lai Choi2Leonard Hsu Yuen3Suk-Ming Yim4Keith Shun-Kit Chan5Jimmy Shiu-Ming Lai6Ian Yat-Hin Wong7Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong KongDepartment of Microbiology, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong KongDepartment of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong KongDepartment of Ophthalmology, Queen Mary Hospital, Pok Fu Lam, Hong KongDepartment of Ophthalmology, Queen Mary Hospital, Pok Fu Lam, Hong KongDepartment of Ophthalmology, Queen Mary Hospital, Pok Fu Lam, Hong KongDepartment of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong KongDepartment of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong KongPurpose. To study the risk factors, microbial profile, antibiotic susceptibility pattern, and outcome for microbial keratitis over the past 10 years in a tertiary center in Hong Kong. Methods. All cases with corneal scraping performed in Queen Mary Hospital, Hong Kong from January 2004 to December 2013 were included. Clinical outcome was defined as poor if the final visual acuity (VA) was abnormal or worse than presenting VA, a major complication occurred, or therapeutic keratoplasty was required. Results. 347 scrapes were performed in the 10-year period growing 130 microorganisms (32.3% culture positive rate). Contact lens use was the commonest risk factor. The commonest isolates were coagulase-negative Staphylococcus and Pseudomonas aeruginosa. Fluoroquinolone susceptibility was tested in 47 Gram-negative bacteria with 93.6% susceptibility (100% for Pseudomonas). 90.7% of cases had good visual outcome. Multivariate logistic regression showed age (p=0.03), trauma (p=0.006), and ulcer size >3 mm (p=0.039) to be independently associated with poor outcome. Conclusion. There was no shifting trend in the isolate distribution or emergence of resistant strains in our study. Contact lens wear was the commonest risk factor, with Pseudomonas being the most frequent isolate in this group. It remained 100% susceptible to fluoroquinolones and 97% cases had good visual outcome.http://dx.doi.org/10.1155/2015/769436 |
| spellingShingle | Alex Lap-Ki Ng Kelvin Kai-Wang To Chile Chi-Lai Choi Leonard Hsu Yuen Suk-Ming Yim Keith Shun-Kit Chan Jimmy Shiu-Ming Lai Ian Yat-Hin Wong Predisposing Factors, Microbial Characteristics, and Clinical Outcome of Microbial Keratitis in a Tertiary Centre in Hong Kong: A 10-Year Experience Journal of Ophthalmology |
| title | Predisposing Factors, Microbial Characteristics, and Clinical Outcome of Microbial Keratitis in a Tertiary Centre in Hong Kong: A 10-Year Experience |
| title_full | Predisposing Factors, Microbial Characteristics, and Clinical Outcome of Microbial Keratitis in a Tertiary Centre in Hong Kong: A 10-Year Experience |
| title_fullStr | Predisposing Factors, Microbial Characteristics, and Clinical Outcome of Microbial Keratitis in a Tertiary Centre in Hong Kong: A 10-Year Experience |
| title_full_unstemmed | Predisposing Factors, Microbial Characteristics, and Clinical Outcome of Microbial Keratitis in a Tertiary Centre in Hong Kong: A 10-Year Experience |
| title_short | Predisposing Factors, Microbial Characteristics, and Clinical Outcome of Microbial Keratitis in a Tertiary Centre in Hong Kong: A 10-Year Experience |
| title_sort | predisposing factors microbial characteristics and clinical outcome of microbial keratitis in a tertiary centre in hong kong a 10 year experience |
| url | http://dx.doi.org/10.1155/2015/769436 |
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