Iron metabolism in a mouse model of hepatocellular carcinoma

Iron metabolism in a mouse model of hepatocellular carcinoma

Abstract Hepatocellular carcinoma (HCC) remains the most prevalent type of primary liver cancer worldwide. p53 is one of the most frequently mutated tumor-suppressor genes in HCC and its deficiency in hepatocytes triggers tumor formation in mice. To investigate iron metabolism during liver carcinoge...

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Main Authors: Dilay Yilmaz, Umesh Tharehalli, Rossana Paganoni, Paul Knoop, Andreas Gruber, Yuexin Chen, Rui Dong, Frank Leithäuser, Thomas Seufferlein, Kerstin Leopold, André Lechel, Maja Vujić Spasić
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Iron metabolism
Trace elements
Liver cancer
Hepcidin
Transferrin receptor
p53
Online Access:https://doi.org/10.1038/s41598-025-86486-x
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https://doi.org/10.1038/s41598-025-86486-x

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