IgG autoantibodies in bullous pemphigoid induce a pathogenic MyD88-dependent pro-inflammatory response in keratinocytes

IgG autoantibodies in bullous pemphigoid induce a pathogenic MyD88-dependent pro-inflammatory response in keratinocytes

Abstract Autoantibodies in bullous pemphigoid (BP) are known to activate the innate immune response. Nevertheless, the direct effect of autoantibodies on keratinocytes and the contribution of keratinocyte responses to the pathology of BP are largely unknown. Here, by performing multiplex immunoassay...

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Main Authors: Lei Bao, Christian F. Guerrero-Juarez, Jing Li, Manuela Pigors, Shirin Emtenani, Yingzi Liu, Adrian P. Mansini, Yulu F. Wang, Aadil Ahmed, Norito Ishii, Takashi Hashimoto, Bethany E. Perez White, Stefan Green, Kevin Kunstman, Nicole C. Nowak, Connor Cole, Mrinal K. Sarkar, Johann E. Gudjonsson, Macias Virgilia, Maria Sverdlov, M. Allen McAlexander, Christopher McCrae, Christopher D. Nazaroff, Enno Schmidt, Kyle T. Amber
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62495-2
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