Utility of renal replacement therapy in poisoning and drug overdosage
Toxic and prescribed drug ingestions are a significant cause of pediatric morbidity and mortality. Management of the poisoned patient begins with a thorough evaluation, identification of the agent(s) involved, and assessment of severity and symptoms. Therapy consists of the provision of supportive c...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-09-01
|
| Series: | Journal of Pediatric Critical Care |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jpcc.jpcc_64_24 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832590877115023360 |
|---|---|
| author | Rohit Bhowmick Sasidaran Kandasamy |
| author_facet | Rohit Bhowmick Sasidaran Kandasamy |
| author_sort | Rohit Bhowmick |
| collection | DOAJ |
| description | Toxic and prescribed drug ingestions are a significant cause of pediatric morbidity and mortality. Management of the poisoned patient begins with a thorough evaluation, identification of the agent(s) involved, and assessment of severity and symptoms. Therapy consists of the provision of supportive care, prevention of poison absorption, use of antidotes, and, when appropriate, the use of renal replacement therapy (RRT) to enhance the elimination of the poison. Among several elimination techniques, extracorporeal treatment such as RRT can be lifesaving as it rapidly removes the toxin independent of the patient’s indigenous clearance. Hemodialysis remains the most commonly used RRT for toxin removal, and the role of continuous RRT and therapeutic plasma exchange is emerging. To properly utilize the RRT, the clinician should understand the chemical properties of the toxins and the underlying mechanism of clearance by the concerned RRT technique. Although pediatric literature is mainly limited to case reports, timely initiation of RRT helps manage children with poisoning and drug overdose. |
| format | Article |
| id | doaj-art-4b7a75b244b4451dafb53de5eb191acc |
| institution | Kabale University |
| issn | 2349-6592 2455-7099 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pediatric Critical Care |
| spelling | doaj-art-4b7a75b244b4451dafb53de5eb191acc2025-01-23T06:03:52ZengWolters Kluwer Medknow PublicationsJournal of Pediatric Critical Care2349-65922455-70992024-09-0111522723210.4103/jpcc.jpcc_64_24Utility of renal replacement therapy in poisoning and drug overdosageRohit BhowmickSasidaran KandasamyToxic and prescribed drug ingestions are a significant cause of pediatric morbidity and mortality. Management of the poisoned patient begins with a thorough evaluation, identification of the agent(s) involved, and assessment of severity and symptoms. Therapy consists of the provision of supportive care, prevention of poison absorption, use of antidotes, and, when appropriate, the use of renal replacement therapy (RRT) to enhance the elimination of the poison. Among several elimination techniques, extracorporeal treatment such as RRT can be lifesaving as it rapidly removes the toxin independent of the patient’s indigenous clearance. Hemodialysis remains the most commonly used RRT for toxin removal, and the role of continuous RRT and therapeutic plasma exchange is emerging. To properly utilize the RRT, the clinician should understand the chemical properties of the toxins and the underlying mechanism of clearance by the concerned RRT technique. Although pediatric literature is mainly limited to case reports, timely initiation of RRT helps manage children with poisoning and drug overdose.https://journals.lww.com/10.4103/jpcc.jpcc_64_24clearancediffusionhemodialysisrenal replacement therapyvolume of distribution |
| spellingShingle | Rohit Bhowmick Sasidaran Kandasamy Utility of renal replacement therapy in poisoning and drug overdosage Journal of Pediatric Critical Care clearance diffusion hemodialysis renal replacement therapy volume of distribution |
| title | Utility of renal replacement therapy in poisoning and drug overdosage |
| title_full | Utility of renal replacement therapy in poisoning and drug overdosage |
| title_fullStr | Utility of renal replacement therapy in poisoning and drug overdosage |
| title_full_unstemmed | Utility of renal replacement therapy in poisoning and drug overdosage |
| title_short | Utility of renal replacement therapy in poisoning and drug overdosage |
| title_sort | utility of renal replacement therapy in poisoning and drug overdosage |
| topic | clearance diffusion hemodialysis renal replacement therapy volume of distribution |
| url | https://journals.lww.com/10.4103/jpcc.jpcc_64_24 |
| work_keys_str_mv | AT rohitbhowmick utilityofrenalreplacementtherapyinpoisoninganddrugoverdosage AT sasidarankandasamy utilityofrenalreplacementtherapyinpoisoninganddrugoverdosage |