Influence of Salvia miltiorrhizae on the Mesenteric Lymph Node of Rats with Severe Acute Pancreatitis or Obstructive Jaundice
Objective. To observe the effect of salvia miltiorrhizae injection on inflammatory mediator levels and mesenteric lymph nodes in severe acute pancreatitis (SAP) and obstructive jaundice (OJ) rats and explore the protective mechanism of salvia miltiorrhizae on the lymph nodes of these rats. Methods....
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2009/675195 |
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| author | Zhang Xiping Zhang Jie Ye Shuyun Wang Qili Feng Guanghua Pan Yan |
| author_facet | Zhang Xiping Zhang Jie Ye Shuyun Wang Qili Feng Guanghua Pan Yan |
| author_sort | Zhang Xiping |
| collection | DOAJ |
| description | Objective. To observe the effect of salvia miltiorrhizae injection on inflammatory mediator levels and mesenteric lymph nodes in severe acute pancreatitis (SAP) and obstructive jaundice (OJ) rats and explore the protective mechanism of salvia miltiorrhizae on the lymph nodes of these rats. Methods. A total of 288 rats were used in SAP-associated and OJ-associated experiments. The rats were randomly divided into sham-operated group, model control group, and treated group. At various time points after operation, the pathological changes in mesenteric lymph nodes of rats in each group were observed, respectively. Results. The pathological severity scores in lymph nodes of SAP rats in treated group were significantly lower than those in model control group (P<.05) while the pathological changes in lymph nodes of OJ rats in treated group also showed varying degrees of mitigation. Conclusion. Salvia miltiorrhizae can exert protective effects on the lymph nodes of SAP or OJ rats via a mechanism that is associated with reducing the contents of inflammatory mediators in blood. |
| format | Article |
| id | doaj-art-4b7931fc9a6a4f7aa12bf8b215db4124 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4b7931fc9a6a4f7aa12bf8b215db41242025-02-03T01:10:14ZengWileyMediators of Inflammation0962-93511466-18612009-01-01200910.1155/2009/675195675195Influence of Salvia miltiorrhizae on the Mesenteric Lymph Node of Rats with Severe Acute Pancreatitis or Obstructive JaundiceZhang Xiping0Zhang Jie1Ye Shuyun2Wang Qili3Feng Guanghua4Pan Yan5Department of General Surgery, Hangzhou First People’s Hospital, Zhejiang Province, Hangzhou 310006, ChinaThe First College of Clinical Medicine, Zhejiang Traditional Chinese Medicine University, Zhejiang Province, Hangzhou 310053, ChinaThe First College of Clinical Medicine, Zhejiang Traditional Chinese Medicine University, Zhejiang Province, Hangzhou 310053, ChinaThe First College of Clinical Medicine, Zhejiang Traditional Chinese Medicine University, Zhejiang Province, Hangzhou 310053, ChinaDepartment of General Surgery, Hangzhou First People’s Hospital, Zhejiang Province, Hangzhou 310006, ChinaThe First College of Clinical Medicine, Zhejiang Traditional Chinese Medicine University, Zhejiang Province, Hangzhou 310053, ChinaObjective. To observe the effect of salvia miltiorrhizae injection on inflammatory mediator levels and mesenteric lymph nodes in severe acute pancreatitis (SAP) and obstructive jaundice (OJ) rats and explore the protective mechanism of salvia miltiorrhizae on the lymph nodes of these rats. Methods. A total of 288 rats were used in SAP-associated and OJ-associated experiments. The rats were randomly divided into sham-operated group, model control group, and treated group. At various time points after operation, the pathological changes in mesenteric lymph nodes of rats in each group were observed, respectively. Results. The pathological severity scores in lymph nodes of SAP rats in treated group were significantly lower than those in model control group (P<.05) while the pathological changes in lymph nodes of OJ rats in treated group also showed varying degrees of mitigation. Conclusion. Salvia miltiorrhizae can exert protective effects on the lymph nodes of SAP or OJ rats via a mechanism that is associated with reducing the contents of inflammatory mediators in blood.http://dx.doi.org/10.1155/2009/675195 |
| spellingShingle | Zhang Xiping Zhang Jie Ye Shuyun Wang Qili Feng Guanghua Pan Yan Influence of Salvia miltiorrhizae on the Mesenteric Lymph Node of Rats with Severe Acute Pancreatitis or Obstructive Jaundice Mediators of Inflammation |
| title | Influence of Salvia miltiorrhizae on the Mesenteric Lymph Node of Rats with Severe Acute Pancreatitis or Obstructive Jaundice |
| title_full | Influence of Salvia miltiorrhizae on the Mesenteric Lymph Node of Rats with Severe Acute Pancreatitis or Obstructive Jaundice |
| title_fullStr | Influence of Salvia miltiorrhizae on the Mesenteric Lymph Node of Rats with Severe Acute Pancreatitis or Obstructive Jaundice |
| title_full_unstemmed | Influence of Salvia miltiorrhizae on the Mesenteric Lymph Node of Rats with Severe Acute Pancreatitis or Obstructive Jaundice |
| title_short | Influence of Salvia miltiorrhizae on the Mesenteric Lymph Node of Rats with Severe Acute Pancreatitis or Obstructive Jaundice |
| title_sort | influence of salvia miltiorrhizae on the mesenteric lymph node of rats with severe acute pancreatitis or obstructive jaundice |
| url | http://dx.doi.org/10.1155/2009/675195 |
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