Inhibition of CD45-specific phosphatase activity restores the differentiation potential of aged mesenchymal stromal cells: implications in regenerative medicine

Inhibition of CD45-specific phosphatase activity restores the differentiation potential of aged mesenchymal stromal cells: implications in regenerative medicine

Abstract Background Aging affects the reparative potency of mesenchymal stem/stromal cells (MSCs) by diminishing their proliferation and differentiation capability; making them unsuitable for regenerative purposes. Earlier we showed that MSCs acquire the expression of CD45 as a consequence of aging,...

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Bibliographic Details
Main Authors: Madhurima Das, Isha Behere, Ganesh Ingavle, Anuradha Vaidya, Vaijayanti Prakash Kale
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Biological Research
Subjects:
Mesenchymal stem/stromal cells
CD45
Protein tyrosine phosphatase
Regulatory kinases
Differentiation
Regenerative medicine
Online Access:https://doi.org/10.1186/s40659-025-00603-8
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