System-Wide Expression and Function of Olfactory Receptors in Mammals
Olfactory receptors (ORs) in mammals are generally considered to function as chemosensors in the olfactory organs of animals. They are membrane proteins that traverse the cytoplasmic membrane seven times and work generally by coupling to heterotrimeric G protein. The OR is a G protein‒coupled recept...
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BioMed Central
2018-03-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gi-2018-16-1-2.pdf |
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| author | S. June Oh |
| author_facet | S. June Oh |
| author_sort | S. June Oh |
| collection | DOAJ |
| description | Olfactory receptors (ORs) in mammals are generally considered to function as chemosensors in the olfactory organs of animals. They are membrane proteins that traverse the cytoplasmic membrane seven times and work generally by coupling to heterotrimeric G protein. The OR is a G protein‒coupled receptor that binds the guanine nucleotide-binding Gαolf subunit and the Gβγ dimer to recognize a wide spectrum of organic compounds in accordance with its cognate ligand. Mammalian ORs were originally identified from the olfactory epithelium of rat. However, it has been recently reported that the expression of ORs is not limited to the olfactory organ. In recent decades, they have been found to be expressed in diverse organs or tissues and even tumors in mammals. In this review, the expression and expected function of olfactory receptors that exist throughout an organism’s system are discussed. |
| format | Article |
| id | doaj-art-4b58090230ff42fc9c252ce02c8d55ac |
| institution | Kabale University |
| issn | 2234-0742 |
| language | English |
| publishDate | 2018-03-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-4b58090230ff42fc9c252ce02c8d55ac2025-02-02T01:30:27ZengBioMed CentralGenomics & Informatics2234-07422018-03-011612910.5808/GI.2018.16.1.2504System-Wide Expression and Function of Olfactory Receptors in MammalsS. June Oh0 Department of Pharmacology, Inje University College of Medicine, Busan 47392, KoreaOlfactory receptors (ORs) in mammals are generally considered to function as chemosensors in the olfactory organs of animals. They are membrane proteins that traverse the cytoplasmic membrane seven times and work generally by coupling to heterotrimeric G protein. The OR is a G protein‒coupled receptor that binds the guanine nucleotide-binding Gαolf subunit and the Gβγ dimer to recognize a wide spectrum of organic compounds in accordance with its cognate ligand. Mammalian ORs were originally identified from the olfactory epithelium of rat. However, it has been recently reported that the expression of ORs is not limited to the olfactory organ. In recent decades, they have been found to be expressed in diverse organs or tissues and even tumors in mammals. In this review, the expression and expected function of olfactory receptors that exist throughout an organism’s system are discussed.http://genominfo.org/upload/pdf/gi-2018-16-1-2.pdfchemosensory receptorectopic expressionG protein-coupled receptorolfactory receptorsystem-wide expression |
| spellingShingle | S. June Oh System-Wide Expression and Function of Olfactory Receptors in Mammals Genomics & Informatics chemosensory receptor ectopic expression G protein-coupled receptor olfactory receptor system-wide expression |
| title | System-Wide Expression and Function of Olfactory Receptors in Mammals |
| title_full | System-Wide Expression and Function of Olfactory Receptors in Mammals |
| title_fullStr | System-Wide Expression and Function of Olfactory Receptors in Mammals |
| title_full_unstemmed | System-Wide Expression and Function of Olfactory Receptors in Mammals |
| title_short | System-Wide Expression and Function of Olfactory Receptors in Mammals |
| title_sort | system wide expression and function of olfactory receptors in mammals |
| topic | chemosensory receptor ectopic expression G protein-coupled receptor olfactory receptor system-wide expression |
| url | http://genominfo.org/upload/pdf/gi-2018-16-1-2.pdf |
| work_keys_str_mv | AT sjuneoh systemwideexpressionandfunctionofolfactoryreceptorsinmammals |