Memory Effects of Benzodiazepines: Memory Stages and Types Versus Binding-Site Subtypes
Benzodiazepines are well established as inhibitory modulators of memory processing. This effect is especially prominent when applied before the acquisition phase of a memory task. This minireview concentrates on the putative subtype selectivity of the acquisition-impairing action of benzodiazepines....
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2005-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/NP.2005.289 |
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| author | Miroslav M. Savic Dragan I. Obradovic Nenad D. Ugrešic Dubravko R. Bokonjic |
| author_facet | Miroslav M. Savic Dragan I. Obradovic Nenad D. Ugrešic Dubravko R. Bokonjic |
| author_sort | Miroslav M. Savic |
| collection | DOAJ |
| description | Benzodiazepines are well established as inhibitory modulators of memory processing. This effect is especially prominent when applied before the acquisition phase of a memory task. This minireview concentrates on the putative subtype selectivity of the acquisition-impairing action of benzodiazepines. Namely, recent genetic studies and standard behavioral tests employing subtype-selective ligands pointed to the predominant involvement of two subtypes of benzodiazepine binding sites in memory modulation. Explicit memory learning seems to be affected through the GABAA receptors containing the α1 and α5 subunits, whereas the effects on procedural memory can be mainly mediated by the α1 subunit. The pervading involvement of the α1 subunit in memory modulation is not at all unexpected because this subunit is the major subtype, present in 60% of all GABAA receptors. On the other hand, the role of α5 subunits, mainly expressed in the hippocampus, in modulating distinct forms of memory gives promise of selective pharmacological coping with certain memory deficit states. |
| format | Article |
| id | doaj-art-4b4a9a0b2fa0491ebbeffd747ef38e21 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-4b4a9a0b2fa0491ebbeffd747ef38e212025-02-03T06:01:14ZengWileyNeural Plasticity2090-59041687-54432005-01-0112428929810.1155/NP.2005.289Memory Effects of Benzodiazepines: Memory Stages and Types Versus Binding-Site SubtypesMiroslav M. Savic0Dragan I. Obradovic1Nenad D. Ugrešic2Dubravko R. Bokonjic3Department of Pharmacology, Faculty of Pharmacy, University of Belgrade, Belgrade 11000, Serbia and MontenegroDepartment of Pharmacology, Medical Faculty, University of Belgrade, Belgrade 11000, Serbia and MontenegroDepartment of Pharmacology, Faculty of Pharmacy, University of Belgrade, Belgrade 11000, Serbia and MontenegroNational Poison Center, Military Medical Academy, Crnotravska 17, Belgrade 11000, Serbia and MontenegroBenzodiazepines are well established as inhibitory modulators of memory processing. This effect is especially prominent when applied before the acquisition phase of a memory task. This minireview concentrates on the putative subtype selectivity of the acquisition-impairing action of benzodiazepines. Namely, recent genetic studies and standard behavioral tests employing subtype-selective ligands pointed to the predominant involvement of two subtypes of benzodiazepine binding sites in memory modulation. Explicit memory learning seems to be affected through the GABAA receptors containing the α1 and α5 subunits, whereas the effects on procedural memory can be mainly mediated by the α1 subunit. The pervading involvement of the α1 subunit in memory modulation is not at all unexpected because this subunit is the major subtype, present in 60% of all GABAA receptors. On the other hand, the role of α5 subunits, mainly expressed in the hippocampus, in modulating distinct forms of memory gives promise of selective pharmacological coping with certain memory deficit states.http://dx.doi.org/10.1155/NP.2005.289 |
| spellingShingle | Miroslav M. Savic Dragan I. Obradovic Nenad D. Ugrešic Dubravko R. Bokonjic Memory Effects of Benzodiazepines: Memory Stages and Types Versus Binding-Site Subtypes Neural Plasticity |
| title | Memory Effects of Benzodiazepines: Memory Stages and Types Versus Binding-Site Subtypes |
| title_full | Memory Effects of Benzodiazepines: Memory Stages and Types Versus Binding-Site Subtypes |
| title_fullStr | Memory Effects of Benzodiazepines: Memory Stages and Types Versus Binding-Site Subtypes |
| title_full_unstemmed | Memory Effects of Benzodiazepines: Memory Stages and Types Versus Binding-Site Subtypes |
| title_short | Memory Effects of Benzodiazepines: Memory Stages and Types Versus Binding-Site Subtypes |
| title_sort | memory effects of benzodiazepines memory stages and types versus binding site subtypes |
| url | http://dx.doi.org/10.1155/NP.2005.289 |
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