Pathophysiological Models of Hypersomnolence Associated With Depression
Up to 25% of patients with depression experience hypersomnolence (e.g., excessive daytime sleepiness, hypersomnia, and/or sleep inertia), which is associated with treatment resistance, overall poorer outcomes, and safety concerns while driving. Hypersomnolence can result from various sleep/neurologi...
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Elsevier
2025-03-01
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| Series: | Biological Psychiatry Global Open Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667174324001587 |
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| author | Christophe Moderie Diane B. Boivin |
| author_facet | Christophe Moderie Diane B. Boivin |
| author_sort | Christophe Moderie |
| collection | DOAJ |
| description | Up to 25% of patients with depression experience hypersomnolence (e.g., excessive daytime sleepiness, hypersomnia, and/or sleep inertia), which is associated with treatment resistance, overall poorer outcomes, and safety concerns while driving. Hypersomnolence can result from various sleep/neurological disorders or side effects from medication but is often medically unexplained in depression. In this review, we aimed to summarize the different pathophysiological models of hypersomnolence in depression to discuss their impact on nosology and to foster the development of better tailored diagnostics and treatments. We identified several potential mechanisms underlying hypersomnolence including a daytime hypoactivity of dopaminergic and noradrenergic systems, nighttime GABA (gamma-aminobutyric acid) hypoactivation, hypoperfusion, and hypoconnectivity in the medial prefrontal cortex, as well as a longer circadian period and light hyposensitivity. In some patients with depression, nighttime hyperarousal can fragment sleep and result in a complaint of excessive daytime sleepiness, thus mimicking hypersomnolence. Others might adopt maladaptive behaviors such as spending excessive time in bed, a term coined clinophilia. Objective markers of hypersomnolence, such as ambulatory ad libitum polysomnography may facilitate distinguishing between conditions that mimic hypersomnolence. Our review identified several clinical targets for hypersomnolence in depression. Low-sodium oxybate, which is approved for idiopathic hypersomnia, needs additional study in patients with depression. Neuromodulation that targets prefrontal cortex anomalies should be systematically explored, while tailored light therapy protocols may mitigate light hyposensitivity. Additionally, cognitive behavioral therapy for hypersomnolence is being developed as a nonpharmacological adjunct to these treatments. |
| format | Article |
| id | doaj-art-4b48cc42ae624752b67e10e6f014bf62 |
| institution | Kabale University |
| issn | 2667-1743 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biological Psychiatry Global Open Science |
| spelling | doaj-art-4b48cc42ae624752b67e10e6f014bf622025-01-29T05:02:21ZengElsevierBiological Psychiatry Global Open Science2667-17432025-03-0152100445Pathophysiological Models of Hypersomnolence Associated With DepressionChristophe Moderie0Diane B. Boivin1Address correspondence to Christophe Moderie, M.D.; Department of Psychiatry, McGill University, Montreal, Quebec, Canada; Centre for Study and Treatment of Circadian Rhythms, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, CanadaDepartment of Psychiatry, McGill University, Montreal, Quebec, Canada; Centre for Study and Treatment of Circadian Rhythms, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, CanadaUp to 25% of patients with depression experience hypersomnolence (e.g., excessive daytime sleepiness, hypersomnia, and/or sleep inertia), which is associated with treatment resistance, overall poorer outcomes, and safety concerns while driving. Hypersomnolence can result from various sleep/neurological disorders or side effects from medication but is often medically unexplained in depression. In this review, we aimed to summarize the different pathophysiological models of hypersomnolence in depression to discuss their impact on nosology and to foster the development of better tailored diagnostics and treatments. We identified several potential mechanisms underlying hypersomnolence including a daytime hypoactivity of dopaminergic and noradrenergic systems, nighttime GABA (gamma-aminobutyric acid) hypoactivation, hypoperfusion, and hypoconnectivity in the medial prefrontal cortex, as well as a longer circadian period and light hyposensitivity. In some patients with depression, nighttime hyperarousal can fragment sleep and result in a complaint of excessive daytime sleepiness, thus mimicking hypersomnolence. Others might adopt maladaptive behaviors such as spending excessive time in bed, a term coined clinophilia. Objective markers of hypersomnolence, such as ambulatory ad libitum polysomnography may facilitate distinguishing between conditions that mimic hypersomnolence. Our review identified several clinical targets for hypersomnolence in depression. Low-sodium oxybate, which is approved for idiopathic hypersomnia, needs additional study in patients with depression. Neuromodulation that targets prefrontal cortex anomalies should be systematically explored, while tailored light therapy protocols may mitigate light hyposensitivity. Additionally, cognitive behavioral therapy for hypersomnolence is being developed as a nonpharmacological adjunct to these treatments.http://www.sciencedirect.com/science/article/pii/S2667174324001587Circadian rhythmsExcessive daytime sleepinessHypersomnolenceMood disordersSleep |
| spellingShingle | Christophe Moderie Diane B. Boivin Pathophysiological Models of Hypersomnolence Associated With Depression Biological Psychiatry Global Open Science Circadian rhythms Excessive daytime sleepiness Hypersomnolence Mood disorders Sleep |
| title | Pathophysiological Models of Hypersomnolence Associated With Depression |
| title_full | Pathophysiological Models of Hypersomnolence Associated With Depression |
| title_fullStr | Pathophysiological Models of Hypersomnolence Associated With Depression |
| title_full_unstemmed | Pathophysiological Models of Hypersomnolence Associated With Depression |
| title_short | Pathophysiological Models of Hypersomnolence Associated With Depression |
| title_sort | pathophysiological models of hypersomnolence associated with depression |
| topic | Circadian rhythms Excessive daytime sleepiness Hypersomnolence Mood disorders Sleep |
| url | http://www.sciencedirect.com/science/article/pii/S2667174324001587 |
| work_keys_str_mv | AT christophemoderie pathophysiologicalmodelsofhypersomnolenceassociatedwithdepression AT dianebboivin pathophysiologicalmodelsofhypersomnolenceassociatedwithdepression |