Extracts and isolated compounds from the Acorus calamus L. (sweet flag) rhizome showed distinct antimetastatic activity against MDA-MB-231 breast cancer cells
The present work aims to investigate and validate the medicinal potential of Acorus calamus, a plant known for its high therapeutic potential. The focus was identifying biologically active extracts and compounds that exhibit promising anticancer properties. The cytotoxicity of the extracts and compo...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Maximum Academic Press
2024-01-01
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| Series: | Medicinal Plant Biology |
| Subjects: | |
| Online Access: | https://www.maxapress.com/article/doi/10.48130/mpb-0024-0021 |
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| Summary: | The present work aims to investigate and validate the medicinal potential of Acorus calamus, a plant known for its high therapeutic potential. The focus was identifying biologically active extracts and compounds that exhibit promising anticancer properties. The cytotoxicity of the extracts and compounds extracted from the rhizomes of A. calamus was assessed in three different cancer cell lines: lung carcinoma (A549), colon carcinoma (HCT-116), and breast carcinoma (MDA-MB-231). The application of extracts derived from the rhizome of A. calamus significantly inhibited cell proliferation in various cancer cell lines, including lung, colon, and breast cancer cells. Furthermore, the isolated compounds ACS08 (stearic acid), ACS06 (beta-sitosterol), and ACS02 (β-asarone) exhibited superior anticancer activity against all the tested cancer cell lines, with an inhibition rate of ≥ 50%. Compared with ACS06 and ACS02, ACS08 exhibited greater cytotoxicity. Among the panel of cancer cell lines utilized, compound ACS08 exhibited greater efficacy against the MDA-MB-231 breast cancer cell line, as evidenced by an IC50 estimation of 55.89 μM. |
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| ISSN: | 2835-6969 |