Targeting CD39 boosts PD-1 blockade antitumor therapeutic efficacy via strengthening CD8 + TILs function and recruiting B cells in cervical cancer

Targeting CD39 boosts PD-1 blockade antitumor therapeutic efficacy via strengthening CD8 + TILs function and recruiting B cells in cervical cancer

Abstract Although the programmed cell death protein 1 (PD-1) blockade has been authorized for the treatment of recurrent and metastatic cervical cancer (CC) patients, a significant proportion of CC patients show low objective response rates (ORR) to immune checkpoint blockades (ICBs). Therefore, ide...

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Bibliographic Details
Main Authors: Lili Jiang, Tong Wu, Xinyu Qu, Shuqi Li, Qi’an Jiang, Tingting Ren, Jiali Liang, Yan Ding, Keqin Hua, Zhongmin Tang, Junjun Qiu
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Nanobiotechnology
Subjects:
Cervical cancer (CC)
Tumor microenvironment
Immune checkpoint blockage (ICB)
αCD39
B cells
Exhausted T cells
Online Access:https://doi.org/10.1186/s12951-025-03500-0
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https://doi.org/10.1186/s12951-025-03500-0

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