Oxaliplatin-Induced Pulmonary Toxicity in Gastrointestinal Malignancies: Two Case Reports and Review of the Literature
Oxaliplatin is a common chemotherapy drug, used mainly for colon and gastric cancer. Most common side effects are peripheral sensory neuropathy, hematological toxicity, and allergic reactions. A less common side effect is pulmonary toxicity, characterized mainly by interstitial pneumonitis. The inci...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2015/341064 |
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| _version_ | 1832552426127753216 |
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| author | Mor Moskovitz Mira Wollner Nissim Haim |
| author_facet | Mor Moskovitz Mira Wollner Nissim Haim |
| author_sort | Mor Moskovitz |
| collection | DOAJ |
| description | Oxaliplatin is a common chemotherapy drug, used mainly for colon and gastric cancer. Most common side effects are peripheral sensory neuropathy, hematological toxicity, and allergic reactions. A less common side effect is pulmonary toxicity, characterized mainly by interstitial pneumonitis. The incidence of this side effect is unknown, but the toxicity can be fatal. Twenty-six cases of pulmonary toxicity have been described in the literature, seven in the setting of adjuvant treatment. We describe two fatal cases of pulmonary injury related to oxaliplatin and a review of the literature. |
| format | Article |
| id | doaj-art-4b3142004aea4dc699a5995bc942c8ad |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-4b3142004aea4dc699a5995bc942c8ad2025-02-03T05:58:37ZengWileyCase Reports in Oncological Medicine2090-67062090-67142015-01-01201510.1155/2015/341064341064Oxaliplatin-Induced Pulmonary Toxicity in Gastrointestinal Malignancies: Two Case Reports and Review of the LiteratureMor Moskovitz0Mira Wollner1Nissim Haim2Division of Oncology, Rambam Health Care Campus, 3109601 Haifa, IsraelDivision of Oncology, Rambam Health Care Campus, 3109601 Haifa, IsraelDivision of Oncology, Rambam Health Care Campus, 3109601 Haifa, IsraelOxaliplatin is a common chemotherapy drug, used mainly for colon and gastric cancer. Most common side effects are peripheral sensory neuropathy, hematological toxicity, and allergic reactions. A less common side effect is pulmonary toxicity, characterized mainly by interstitial pneumonitis. The incidence of this side effect is unknown, but the toxicity can be fatal. Twenty-six cases of pulmonary toxicity have been described in the literature, seven in the setting of adjuvant treatment. We describe two fatal cases of pulmonary injury related to oxaliplatin and a review of the literature.http://dx.doi.org/10.1155/2015/341064 |
| spellingShingle | Mor Moskovitz Mira Wollner Nissim Haim Oxaliplatin-Induced Pulmonary Toxicity in Gastrointestinal Malignancies: Two Case Reports and Review of the Literature Case Reports in Oncological Medicine |
| title | Oxaliplatin-Induced Pulmonary Toxicity in Gastrointestinal Malignancies: Two Case Reports and Review of the Literature |
| title_full | Oxaliplatin-Induced Pulmonary Toxicity in Gastrointestinal Malignancies: Two Case Reports and Review of the Literature |
| title_fullStr | Oxaliplatin-Induced Pulmonary Toxicity in Gastrointestinal Malignancies: Two Case Reports and Review of the Literature |
| title_full_unstemmed | Oxaliplatin-Induced Pulmonary Toxicity in Gastrointestinal Malignancies: Two Case Reports and Review of the Literature |
| title_short | Oxaliplatin-Induced Pulmonary Toxicity in Gastrointestinal Malignancies: Two Case Reports and Review of the Literature |
| title_sort | oxaliplatin induced pulmonary toxicity in gastrointestinal malignancies two case reports and review of the literature |
| url | http://dx.doi.org/10.1155/2015/341064 |
| work_keys_str_mv | AT mormoskovitz oxaliplatininducedpulmonarytoxicityingastrointestinalmalignanciestwocasereportsandreviewoftheliterature AT mirawollner oxaliplatininducedpulmonarytoxicityingastrointestinalmalignanciestwocasereportsandreviewoftheliterature AT nissimhaim oxaliplatininducedpulmonarytoxicityingastrointestinalmalignanciestwocasereportsandreviewoftheliterature |