Extracellular-Matrix Mechanics Regulate the Ocular Physiological and Pathological Activities
The extracellular matrix (ECM) is a noncellular structure that plays an indispensable role in a series of cell life activities. Accumulating studies have demonstrated that ECM stiffness, a type of mechanical forces, exerts a pivotal influence on regulating organogenesis, tissue homeostasis, and the...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2023/7626920 |
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| _version_ | 1832559688610217984 |
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| author | Ran Zhang Bo Li Heng Li |
| author_facet | Ran Zhang Bo Li Heng Li |
| author_sort | Ran Zhang |
| collection | DOAJ |
| description | The extracellular matrix (ECM) is a noncellular structure that plays an indispensable role in a series of cell life activities. Accumulating studies have demonstrated that ECM stiffness, a type of mechanical forces, exerts a pivotal influence on regulating organogenesis, tissue homeostasis, and the occurrence and development of miscellaneous diseases. Nevertheless, the role of ECM stiffness in ophthalmology is rarely discussed. In this review, we focus on describing the important role of ECM stiffness and its composition in multiple ocular structures (including cornea, retina, optic nerve, trabecular reticulum, and vitreous) from a new perspective. The abnormal changes in ECM can trigger physiological and pathological activities of the eye, suggesting that compared with different biochemical factors, the transmission and transduction of force signals triggered by mechanical cues such as ECM stiffness are also universal in different ocular cells. We expect that targeting ECM as a therapeutic approach or designing advanced ECM-based technologies will have a broader application prospect in ophthalmology. |
| format | Article |
| id | doaj-art-4b2fa782094e41c58386b391b584d687 |
| institution | Kabale University |
| issn | 2090-0058 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-4b2fa782094e41c58386b391b584d6872025-02-03T01:29:28ZengWileyJournal of Ophthalmology2090-00582023-01-01202310.1155/2023/7626920Extracellular-Matrix Mechanics Regulate the Ocular Physiological and Pathological ActivitiesRan Zhang0Bo Li1Heng Li2Department of Ophthalmology & OptometryDepartment of OphthalmologyDepartment of Ophthalmology & OptometryThe extracellular matrix (ECM) is a noncellular structure that plays an indispensable role in a series of cell life activities. Accumulating studies have demonstrated that ECM stiffness, a type of mechanical forces, exerts a pivotal influence on regulating organogenesis, tissue homeostasis, and the occurrence and development of miscellaneous diseases. Nevertheless, the role of ECM stiffness in ophthalmology is rarely discussed. In this review, we focus on describing the important role of ECM stiffness and its composition in multiple ocular structures (including cornea, retina, optic nerve, trabecular reticulum, and vitreous) from a new perspective. The abnormal changes in ECM can trigger physiological and pathological activities of the eye, suggesting that compared with different biochemical factors, the transmission and transduction of force signals triggered by mechanical cues such as ECM stiffness are also universal in different ocular cells. We expect that targeting ECM as a therapeutic approach or designing advanced ECM-based technologies will have a broader application prospect in ophthalmology.http://dx.doi.org/10.1155/2023/7626920 |
| spellingShingle | Ran Zhang Bo Li Heng Li Extracellular-Matrix Mechanics Regulate the Ocular Physiological and Pathological Activities Journal of Ophthalmology |
| title | Extracellular-Matrix Mechanics Regulate the Ocular Physiological and Pathological Activities |
| title_full | Extracellular-Matrix Mechanics Regulate the Ocular Physiological and Pathological Activities |
| title_fullStr | Extracellular-Matrix Mechanics Regulate the Ocular Physiological and Pathological Activities |
| title_full_unstemmed | Extracellular-Matrix Mechanics Regulate the Ocular Physiological and Pathological Activities |
| title_short | Extracellular-Matrix Mechanics Regulate the Ocular Physiological and Pathological Activities |
| title_sort | extracellular matrix mechanics regulate the ocular physiological and pathological activities |
| url | http://dx.doi.org/10.1155/2023/7626920 |
| work_keys_str_mv | AT ranzhang extracellularmatrixmechanicsregulatetheocularphysiologicalandpathologicalactivities AT boli extracellularmatrixmechanicsregulatetheocularphysiologicalandpathologicalactivities AT hengli extracellularmatrixmechanicsregulatetheocularphysiologicalandpathologicalactivities |