ABCD3-I and ABCD2 Scores in a TIA Population with Low Stroke Risk
Objectives. We aimed to evaluate the ABCD3-I score and compare it with the ABCD2 score in short- (1 week) and long-term (3 months; 1 year) stroke risk prediction in our post-TIA stroke risk study, MIDNOR TIA. Materials and Methods. We performed a prospective, multicenter study in Central Norway from...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Stroke Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2021/8845898 |
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| author | Fredrik Ildstad Hanne Ellekjær Torgeir Wethal Stian Lydersen Hild Fjærtoft Bent Indredavik |
| author_facet | Fredrik Ildstad Hanne Ellekjær Torgeir Wethal Stian Lydersen Hild Fjærtoft Bent Indredavik |
| author_sort | Fredrik Ildstad |
| collection | DOAJ |
| description | Objectives. We aimed to evaluate the ABCD3-I score and compare it with the ABCD2 score in short- (1 week) and long-term (3 months; 1 year) stroke risk prediction in our post-TIA stroke risk study, MIDNOR TIA. Materials and Methods. We performed a prospective, multicenter study in Central Norway from 2012 to 2015, enrolling 577 patients with TIA. In a subset of patients with complete data for both scores (n=305), we calculated the AUC statistics of the ABCD3-I score and compared this with the ABCD2 score. A telephone follow-up and registry data were used for assessing stroke occurrence. Results. Within 1 week, 3 months, and 1 year, 1.0% (n=3), 3.3% (n=10), and 5.2% (n=16) experienced a stroke, respectively. The AUCs for the ABCD3-I score were 0.72 (95% CI, 0.54 to 0.89) at 1 week, 0.66 (95% CI, 0.53 to 0.80) at 3 months, and 0.68 (0.95% CI, 0.56 to 0.79) at 1 year. The corresponding AUCs for the ABCD2 score were 0.55 (95% CI, 0.24 to 0.86), 0.55 (95% CI, 0.42 to 0.68), and 0.63 (95% CI, 0.50 to 0.76). Conclusions. The ABCD3-I score had limited value in a short-term prediction of subsequent stroke after TIA and did not reliably discriminate between low- and high-risk patients in a long-term follow-up. The ABCD2 score did not predict subsequent stroke accurately at any time point. Since there is a generally lower stroke risk after TIA during the last years, the benefit of these clinical risk scores and their role in TIA management seems limited. Clinical Trial Registration. This trial is registered with NCT02038725 (retrospectively registered, January 16, 2014). |
| format | Article |
| id | doaj-art-4b27d3249dac4680b42a7e0c547b8852 |
| institution | Kabale University |
| issn | 2090-8105 2042-0056 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke Research and Treatment |
| spelling | doaj-art-4b27d3249dac4680b42a7e0c547b88522025-02-03T05:49:26ZengWileyStroke Research and Treatment2090-81052042-00562021-01-01202110.1155/2021/88458988845898ABCD3-I and ABCD2 Scores in a TIA Population with Low Stroke RiskFredrik Ildstad0Hanne Ellekjær1Torgeir Wethal2Stian Lydersen3Hild Fjærtoft4Bent Indredavik5Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, NorwayDepartment of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, NorwayDepartment of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, NorwayRegional Center for Child and Youth Mental Health and Child Welfare, NTNU, P.O. Box 8905, N-7491 Trondheim, NorwayDepartment of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, NorwayDepartment of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, NorwayObjectives. We aimed to evaluate the ABCD3-I score and compare it with the ABCD2 score in short- (1 week) and long-term (3 months; 1 year) stroke risk prediction in our post-TIA stroke risk study, MIDNOR TIA. Materials and Methods. We performed a prospective, multicenter study in Central Norway from 2012 to 2015, enrolling 577 patients with TIA. In a subset of patients with complete data for both scores (n=305), we calculated the AUC statistics of the ABCD3-I score and compared this with the ABCD2 score. A telephone follow-up and registry data were used for assessing stroke occurrence. Results. Within 1 week, 3 months, and 1 year, 1.0% (n=3), 3.3% (n=10), and 5.2% (n=16) experienced a stroke, respectively. The AUCs for the ABCD3-I score were 0.72 (95% CI, 0.54 to 0.89) at 1 week, 0.66 (95% CI, 0.53 to 0.80) at 3 months, and 0.68 (0.95% CI, 0.56 to 0.79) at 1 year. The corresponding AUCs for the ABCD2 score were 0.55 (95% CI, 0.24 to 0.86), 0.55 (95% CI, 0.42 to 0.68), and 0.63 (95% CI, 0.50 to 0.76). Conclusions. The ABCD3-I score had limited value in a short-term prediction of subsequent stroke after TIA and did not reliably discriminate between low- and high-risk patients in a long-term follow-up. The ABCD2 score did not predict subsequent stroke accurately at any time point. Since there is a generally lower stroke risk after TIA during the last years, the benefit of these clinical risk scores and their role in TIA management seems limited. Clinical Trial Registration. This trial is registered with NCT02038725 (retrospectively registered, January 16, 2014).http://dx.doi.org/10.1155/2021/8845898 |
| spellingShingle | Fredrik Ildstad Hanne Ellekjær Torgeir Wethal Stian Lydersen Hild Fjærtoft Bent Indredavik ABCD3-I and ABCD2 Scores in a TIA Population with Low Stroke Risk Stroke Research and Treatment |
| title | ABCD3-I and ABCD2 Scores in a TIA Population with Low Stroke Risk |
| title_full | ABCD3-I and ABCD2 Scores in a TIA Population with Low Stroke Risk |
| title_fullStr | ABCD3-I and ABCD2 Scores in a TIA Population with Low Stroke Risk |
| title_full_unstemmed | ABCD3-I and ABCD2 Scores in a TIA Population with Low Stroke Risk |
| title_short | ABCD3-I and ABCD2 Scores in a TIA Population with Low Stroke Risk |
| title_sort | abcd3 i and abcd2 scores in a tia population with low stroke risk |
| url | http://dx.doi.org/10.1155/2021/8845898 |
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