Experimental Hyperthyroidism Decreases Gene Expression and Serum Levels of Adipokines in Obesity
Aims. To analyze the influence of hyperthyroidism on the gene expression and serum concentration of leptin, resistin, and adiponectin in obese animals. Main Methods. Male Wistar rats were randomly divided into two groups: control (C)—fed with commercial chow ad libitum—and obese (OB)—fed with a hyp...
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| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/780890 |
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| author | Renata de Azevedo Melo Luvizotto André Ferreira do Nascimento Maria Teresa de Síbio Regiane Marques Castro Olímpio Sandro José Conde Ana Paula Lima-Leopoldo André Soares Leopoldo Antonio Carlos Cicogna Célia Regina Nogueira |
| author_facet | Renata de Azevedo Melo Luvizotto André Ferreira do Nascimento Maria Teresa de Síbio Regiane Marques Castro Olímpio Sandro José Conde Ana Paula Lima-Leopoldo André Soares Leopoldo Antonio Carlos Cicogna Célia Regina Nogueira |
| author_sort | Renata de Azevedo Melo Luvizotto |
| collection | DOAJ |
| description | Aims. To analyze the influence of hyperthyroidism on the gene expression and serum concentration of leptin, resistin, and adiponectin in obese animals.
Main Methods. Male Wistar rats were randomly divided into two groups: control (C)—fed with commercial chow ad libitum—and obese (OB)—fed with a hypercaloric diet. After group characterization, the OB rats continued receiving a hypercaloric diet and were randomized into two groups: obese animals (OB) and obese with 25 μg triiodothyronine (T3)/100 BW (OT). The T3 dose was administered every day for the last 2 weeks of the study. After 30 weeks the animals were euthanized. Samples of blood and adipose tissue were collected for biochemical and hormonal analyses as well as gene expression of leptin, resistin, and adiponectin. Results. T3 treatment was effective, increasing fT3 levels and decreasing fT4 and TSH serum concentration. Administration of T3 promotes weight loss, decreases all fat deposits, and diminishes serum levels of leptin, resistin, and adiponectin by reducing their gene expression. Conclusions. Our results suggest that T3 modulate serum and gene expression levels of leptin, resistin, and adiponectin in experimental model of obesity, providing new insights regarding the relationship between T3 and adipokines in obesity. |
| format | Article |
| id | doaj-art-4b1e2716d5b24bdc821dde21f5cfaaa0 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-4b1e2716d5b24bdc821dde21f5cfaaa02025-02-03T01:27:37ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/780890780890Experimental Hyperthyroidism Decreases Gene Expression and Serum Levels of Adipokines in ObesityRenata de Azevedo Melo Luvizotto0André Ferreira do Nascimento1Maria Teresa de Síbio2Regiane Marques Castro Olímpio3Sandro José Conde4Ana Paula Lima-Leopoldo5André Soares Leopoldo6Antonio Carlos Cicogna7Célia Regina Nogueira8Department of Internal Medicine, Botucatu School of Medicine, University of São Paulo State, 18618-000 Botucatu, SP, BrazilDepartment of Internal Medicine, Botucatu School of Medicine, University of São Paulo State, 18618-000 Botucatu, SP, BrazilDepartment of Internal Medicine, Botucatu School of Medicine, University of São Paulo State, 18618-000 Botucatu, SP, BrazilDepartment of Internal Medicine, Botucatu School of Medicine, University of São Paulo State, 18618-000 Botucatu, SP, BrazilDepartment of Internal Medicine, Botucatu School of Medicine, University of São Paulo State, 18618-000 Botucatu, SP, BrazilDepartment of Sports, Center of Physical Education and Sports, Federal University of Espirito Santo (UFES), 29075-910 Vitória, ES, BrazilDepartment of Internal Medicine, Botucatu School of Medicine, University of São Paulo State, 18618-000 Botucatu, SP, BrazilDepartment of Internal Medicine, Botucatu School of Medicine, University of São Paulo State, 18618-000 Botucatu, SP, BrazilDepartment of Internal Medicine, Botucatu School of Medicine, University of São Paulo State, 18618-000 Botucatu, SP, BrazilAims. To analyze the influence of hyperthyroidism on the gene expression and serum concentration of leptin, resistin, and adiponectin in obese animals. Main Methods. Male Wistar rats were randomly divided into two groups: control (C)—fed with commercial chow ad libitum—and obese (OB)—fed with a hypercaloric diet. After group characterization, the OB rats continued receiving a hypercaloric diet and were randomized into two groups: obese animals (OB) and obese with 25 μg triiodothyronine (T3)/100 BW (OT). The T3 dose was administered every day for the last 2 weeks of the study. After 30 weeks the animals were euthanized. Samples of blood and adipose tissue were collected for biochemical and hormonal analyses as well as gene expression of leptin, resistin, and adiponectin. Results. T3 treatment was effective, increasing fT3 levels and decreasing fT4 and TSH serum concentration. Administration of T3 promotes weight loss, decreases all fat deposits, and diminishes serum levels of leptin, resistin, and adiponectin by reducing their gene expression. Conclusions. Our results suggest that T3 modulate serum and gene expression levels of leptin, resistin, and adiponectin in experimental model of obesity, providing new insights regarding the relationship between T3 and adipokines in obesity.http://dx.doi.org/10.1100/2012/780890 |
| spellingShingle | Renata de Azevedo Melo Luvizotto André Ferreira do Nascimento Maria Teresa de Síbio Regiane Marques Castro Olímpio Sandro José Conde Ana Paula Lima-Leopoldo André Soares Leopoldo Antonio Carlos Cicogna Célia Regina Nogueira Experimental Hyperthyroidism Decreases Gene Expression and Serum Levels of Adipokines in Obesity The Scientific World Journal |
| title | Experimental Hyperthyroidism Decreases Gene Expression and Serum Levels of Adipokines in Obesity |
| title_full | Experimental Hyperthyroidism Decreases Gene Expression and Serum Levels of Adipokines in Obesity |
| title_fullStr | Experimental Hyperthyroidism Decreases Gene Expression and Serum Levels of Adipokines in Obesity |
| title_full_unstemmed | Experimental Hyperthyroidism Decreases Gene Expression and Serum Levels of Adipokines in Obesity |
| title_short | Experimental Hyperthyroidism Decreases Gene Expression and Serum Levels of Adipokines in Obesity |
| title_sort | experimental hyperthyroidism decreases gene expression and serum levels of adipokines in obesity |
| url | http://dx.doi.org/10.1100/2012/780890 |
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