Adhesive micro-liquid for efficient removal of bacterial biofilm infection
Bacteria are common infectious pathogens that can cause invasive and potentially life-threatening infections. Ionic liquids have emerged as a novel class of alternatives to antibiotics, however their inherent hydrophobicity and immiscible in water exhibits poor adhesion to bacteria and diminishes it...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-04-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425000833 |
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| author | Ying Wang Zhibang Li Lingli Ji Jiao Sun Fei Gao Ruiqing Yu Kai Li Wenjun Wang Weiwei Zhao Qi-Zhi Zhong Shaohua Ge Jianhua Li |
| author_facet | Ying Wang Zhibang Li Lingli Ji Jiao Sun Fei Gao Ruiqing Yu Kai Li Wenjun Wang Weiwei Zhao Qi-Zhi Zhong Shaohua Ge Jianhua Li |
| author_sort | Ying Wang |
| collection | DOAJ |
| description | Bacteria are common infectious pathogens that can cause invasive and potentially life-threatening infections. Ionic liquids have emerged as a novel class of alternatives to antibiotics, however their inherent hydrophobicity and immiscible in water exhibits poor adhesion to bacteria and diminishes its utilization and bioavailability for infection control. Herein, an adhesive metal phenolic encapsulated ionic liquid choline and geranate (CAGE@MPN) microcapsules is designed to address the aforementioned challenges and remove bacterial biofilm infections. The CAGE@MPN microcapsules are prepared through self-assembly of quercetin and ferrous ions on the interface of CAGE and water via metal-phenolic coordination. The MPN interface can stabilize the micro liquid and effectively adhere to bacterial surfaces. The microcapsules can disrupt bacterial cell walls to facilitate the release of cellular contents and destruct the biofilm, thereby exerting a pronounced bactericidal effect. The in vivo bactericidal effect of CAGE@MPN microcapsules is demonstrated in a murine model of Staphylococcus aureus (S. aureus) skin infection. The proposed adhesive micro-liquid system offers a promising strategy for noninvasive and efficient removal of bacterial biofilm infection. |
| format | Article |
| id | doaj-art-4b11b4d91da94de3a8dfab7595dcf586 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-4b11b4d91da94de3a8dfab7595dcf5862025-01-31T05:12:18ZengElsevierMaterials Today Bio2590-00642025-04-0131101525Adhesive micro-liquid for efficient removal of bacterial biofilm infectionYing Wang0Zhibang Li1Lingli Ji2Jiao Sun3Fei Gao4Ruiqing Yu5Kai Li6Wenjun Wang7Weiwei Zhao8Qi-Zhi Zhong9Shaohua Ge10Jianhua Li11Department of Biomaterials, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, ChinaDepartment of Biomaterials, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, ChinaDepartment of Biomaterials, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, ChinaDepartment of Biomaterials, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, ChinaDepartment of Biomaterials, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, ChinaDepartment of Biomaterials, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, ChinaDepartment of Biomaterials, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, ChinaDepartment of Biomaterials, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, ChinaDepartment of Biomaterials, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, China; Corresponding author.School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore; Corresponding author.Department of Biomaterials, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, ChinaDepartment of Biomaterials, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, China; Corresponding author.Bacteria are common infectious pathogens that can cause invasive and potentially life-threatening infections. Ionic liquids have emerged as a novel class of alternatives to antibiotics, however their inherent hydrophobicity and immiscible in water exhibits poor adhesion to bacteria and diminishes its utilization and bioavailability for infection control. Herein, an adhesive metal phenolic encapsulated ionic liquid choline and geranate (CAGE@MPN) microcapsules is designed to address the aforementioned challenges and remove bacterial biofilm infections. The CAGE@MPN microcapsules are prepared through self-assembly of quercetin and ferrous ions on the interface of CAGE and water via metal-phenolic coordination. The MPN interface can stabilize the micro liquid and effectively adhere to bacterial surfaces. The microcapsules can disrupt bacterial cell walls to facilitate the release of cellular contents and destruct the biofilm, thereby exerting a pronounced bactericidal effect. The in vivo bactericidal effect of CAGE@MPN microcapsules is demonstrated in a murine model of Staphylococcus aureus (S. aureus) skin infection. The proposed adhesive micro-liquid system offers a promising strategy for noninvasive and efficient removal of bacterial biofilm infection.http://www.sciencedirect.com/science/article/pii/S2590006425000833AdhesionMetal phenolic networkBacterial infectionIonic liquidAssembly |
| spellingShingle | Ying Wang Zhibang Li Lingli Ji Jiao Sun Fei Gao Ruiqing Yu Kai Li Wenjun Wang Weiwei Zhao Qi-Zhi Zhong Shaohua Ge Jianhua Li Adhesive micro-liquid for efficient removal of bacterial biofilm infection Materials Today Bio Adhesion Metal phenolic network Bacterial infection Ionic liquid Assembly |
| title | Adhesive micro-liquid for efficient removal of bacterial biofilm infection |
| title_full | Adhesive micro-liquid for efficient removal of bacterial biofilm infection |
| title_fullStr | Adhesive micro-liquid for efficient removal of bacterial biofilm infection |
| title_full_unstemmed | Adhesive micro-liquid for efficient removal of bacterial biofilm infection |
| title_short | Adhesive micro-liquid for efficient removal of bacterial biofilm infection |
| title_sort | adhesive micro liquid for efficient removal of bacterial biofilm infection |
| topic | Adhesion Metal phenolic network Bacterial infection Ionic liquid Assembly |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425000833 |
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