Inflammatory Mediators and Angiogenic Factors in Choroidal Neovascularization: Pathogenetic Interactions and Therapeutic Implications
Choroidal neovascularization (CNV) is a common and severe complication in heterogeneous diseases affecting the posterior segment of the eye, the most frequent being represented by age-related macular degeneration. Although the term may suggest just a vascular pathological condition, CNV is more prop...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2010/546826 |
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| author | Claudio Campa Ciro Costagliola Carlo Incorvaia Carl Sheridan Francesco Semeraro Katia De Nadai Adolfo Sebastiani Francesco Parmeggiani |
| author_facet | Claudio Campa Ciro Costagliola Carlo Incorvaia Carl Sheridan Francesco Semeraro Katia De Nadai Adolfo Sebastiani Francesco Parmeggiani |
| author_sort | Claudio Campa |
| collection | DOAJ |
| description | Choroidal neovascularization (CNV) is a common and severe complication in heterogeneous diseases affecting the posterior segment of the eye, the most frequent being represented by age-related macular degeneration. Although the term may suggest just a vascular pathological condition, CNV is more properly definable as an aberrant tissue invasion of endothelial and inflammatory cells, in which both angiogenesis and inflammation are involved. Experimental and clinical evidences show that vascular endothelial growth factor is a key signal in promoting angiogenesis. However, many other molecules, distinctive of the inflammatory response, act as neovascular activators in CNV. These include fibroblast growth factor, transforming growth factor, tumor necrosis factor, interleukins, and complement. This paper reviews the role of inflammatory mediators and angiogenic factors in the development of CNV, proposing pathogenetic assumptions of mutual interaction. As an extension of this concept, new therapeutic approaches geared to have an effect on both the vascular and the extravascular components of CNV are discussed. |
| format | Article |
| id | doaj-art-4b0e966a32cf4714a897ad14340ef831 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4b0e966a32cf4714a897ad14340ef8312025-02-03T01:10:28ZengWileyMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/546826546826Inflammatory Mediators and Angiogenic Factors in Choroidal Neovascularization: Pathogenetic Interactions and Therapeutic ImplicationsClaudio Campa0Ciro Costagliola1Carlo Incorvaia2Carl Sheridan3Francesco Semeraro4Katia De Nadai5Adolfo Sebastiani6Francesco Parmeggiani7Department of Ophthalmology, University of Ferrara, Corso Giovecca 203, 44121 Ferrara, ItalyDepartment of Health Sciences, University of Molise, Campobasso, ItalyDepartment of Ophthalmology, University of Ferrara, Corso Giovecca 203, 44121 Ferrara, ItalySt Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, UKDepartment of Ophthalmology, University of Brescia, Brescia, ItalyDepartment of Ophthalmology, University of Ferrara, Corso Giovecca 203, 44121 Ferrara, ItalyDepartment of Ophthalmology, University of Ferrara, Corso Giovecca 203, 44121 Ferrara, ItalyDepartment of Ophthalmology, University of Ferrara, Corso Giovecca 203, 44121 Ferrara, ItalyChoroidal neovascularization (CNV) is a common and severe complication in heterogeneous diseases affecting the posterior segment of the eye, the most frequent being represented by age-related macular degeneration. Although the term may suggest just a vascular pathological condition, CNV is more properly definable as an aberrant tissue invasion of endothelial and inflammatory cells, in which both angiogenesis and inflammation are involved. Experimental and clinical evidences show that vascular endothelial growth factor is a key signal in promoting angiogenesis. However, many other molecules, distinctive of the inflammatory response, act as neovascular activators in CNV. These include fibroblast growth factor, transforming growth factor, tumor necrosis factor, interleukins, and complement. This paper reviews the role of inflammatory mediators and angiogenic factors in the development of CNV, proposing pathogenetic assumptions of mutual interaction. As an extension of this concept, new therapeutic approaches geared to have an effect on both the vascular and the extravascular components of CNV are discussed.http://dx.doi.org/10.1155/2010/546826 |
| spellingShingle | Claudio Campa Ciro Costagliola Carlo Incorvaia Carl Sheridan Francesco Semeraro Katia De Nadai Adolfo Sebastiani Francesco Parmeggiani Inflammatory Mediators and Angiogenic Factors in Choroidal Neovascularization: Pathogenetic Interactions and Therapeutic Implications Mediators of Inflammation |
| title | Inflammatory Mediators and Angiogenic Factors in Choroidal Neovascularization: Pathogenetic Interactions and Therapeutic Implications |
| title_full | Inflammatory Mediators and Angiogenic Factors in Choroidal Neovascularization: Pathogenetic Interactions and Therapeutic Implications |
| title_fullStr | Inflammatory Mediators and Angiogenic Factors in Choroidal Neovascularization: Pathogenetic Interactions and Therapeutic Implications |
| title_full_unstemmed | Inflammatory Mediators and Angiogenic Factors in Choroidal Neovascularization: Pathogenetic Interactions and Therapeutic Implications |
| title_short | Inflammatory Mediators and Angiogenic Factors in Choroidal Neovascularization: Pathogenetic Interactions and Therapeutic Implications |
| title_sort | inflammatory mediators and angiogenic factors in choroidal neovascularization pathogenetic interactions and therapeutic implications |
| url | http://dx.doi.org/10.1155/2010/546826 |
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