Peripheral Nerve Repair with Cultured Schwann Cells: Getting Closer to the Clinics
Peripheral nerve injuries are a frequent and disabling condition, which affects 13 to 23 per 100.000 persons each year. Severe cases, with structural disruption of the nerve, are associated with poor functional recovery. The experimental treatment using nerve grafts to replace damaged or shortened a...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/413091 |
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| author | Maria Carolina O. Rodrigues Antonio Antunes Rodrigues Loren E. Glover Julio Voltarelli Cesario V. Borlongan |
| author_facet | Maria Carolina O. Rodrigues Antonio Antunes Rodrigues Loren E. Glover Julio Voltarelli Cesario V. Borlongan |
| author_sort | Maria Carolina O. Rodrigues |
| collection | DOAJ |
| description | Peripheral nerve injuries are a frequent and disabling condition, which affects 13 to 23 per 100.000 persons each year. Severe cases, with structural disruption of the nerve, are associated with poor functional recovery. The experimental treatment using nerve grafts to replace damaged or shortened axons is limited by technical difficulties, invasiveness, and mediocre results. Other therapeutic choices include the adjunctive application of cultured Schwann cells and nerve conduits to guide axonal growth. The bone marrow is a rich source of mesenchymal cells, which can be differentiated in vitro into Schwann cells and subsequently engrafted into the damaged nerve. Alternatively, undifferentiated bone marrow mesenchymal cells can be associated with nerve conduits and afterward transplanted. Experimental studies provide evidence of functional, histological, and electromyographical improvement following transplantation of bone-marrow-derived cells in animal models of peripheral nerve injury. This paper focuses on this new therapeutic approach highlighting its direct translational and clinical utility in promoting regeneration of not only acute but perhaps also chronic cases of peripheral nerve damage. |
| format | Article |
| id | doaj-art-4b081194df04414097006c6e13dfcc78 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-4b081194df04414097006c6e13dfcc782025-02-03T05:47:06ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/413091413091Peripheral Nerve Repair with Cultured Schwann Cells: Getting Closer to the ClinicsMaria Carolina O. Rodrigues0Antonio Antunes Rodrigues1Loren E. Glover2Julio Voltarelli3Cesario V. Borlongan4Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B. Downs Boulvard, Tampa, FL 33612, USACenter of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B. Downs Boulvard, Tampa, FL 33612, USACenter of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B. Downs Boulvard, Tampa, FL 33612, USADepartment of Internal Medicine, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14000 Ribeirão Preto, SP, BrazilCenter of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B. Downs Boulvard, Tampa, FL 33612, USAPeripheral nerve injuries are a frequent and disabling condition, which affects 13 to 23 per 100.000 persons each year. Severe cases, with structural disruption of the nerve, are associated with poor functional recovery. The experimental treatment using nerve grafts to replace damaged or shortened axons is limited by technical difficulties, invasiveness, and mediocre results. Other therapeutic choices include the adjunctive application of cultured Schwann cells and nerve conduits to guide axonal growth. The bone marrow is a rich source of mesenchymal cells, which can be differentiated in vitro into Schwann cells and subsequently engrafted into the damaged nerve. Alternatively, undifferentiated bone marrow mesenchymal cells can be associated with nerve conduits and afterward transplanted. Experimental studies provide evidence of functional, histological, and electromyographical improvement following transplantation of bone-marrow-derived cells in animal models of peripheral nerve injury. This paper focuses on this new therapeutic approach highlighting its direct translational and clinical utility in promoting regeneration of not only acute but perhaps also chronic cases of peripheral nerve damage.http://dx.doi.org/10.1100/2012/413091 |
| spellingShingle | Maria Carolina O. Rodrigues Antonio Antunes Rodrigues Loren E. Glover Julio Voltarelli Cesario V. Borlongan Peripheral Nerve Repair with Cultured Schwann Cells: Getting Closer to the Clinics The Scientific World Journal |
| title | Peripheral Nerve Repair with Cultured Schwann Cells: Getting Closer to the Clinics |
| title_full | Peripheral Nerve Repair with Cultured Schwann Cells: Getting Closer to the Clinics |
| title_fullStr | Peripheral Nerve Repair with Cultured Schwann Cells: Getting Closer to the Clinics |
| title_full_unstemmed | Peripheral Nerve Repair with Cultured Schwann Cells: Getting Closer to the Clinics |
| title_short | Peripheral Nerve Repair with Cultured Schwann Cells: Getting Closer to the Clinics |
| title_sort | peripheral nerve repair with cultured schwann cells getting closer to the clinics |
| url | http://dx.doi.org/10.1100/2012/413091 |
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