A Wearable Iron-Based Implant as an Intramedullary Nail in Tibial Shaft Fracture of Sheep
A stable repaired fracture is the key factor responsible for the recovery of a damaged bone. The iron-based implant is one of the biodegradable metals that have been proven safe as a fracture fixation device. The objective of our experimental approach was to examine the potential of the iron-based i...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | International Journal of Biomaterials |
| Online Access: | http://dx.doi.org/10.1155/2019/8798351 |
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| author | Sitaria F. Siallagan Marzuki Silalahi Arief Boediono Sri Estuningsih Deni Noviana |
| author_facet | Sitaria F. Siallagan Marzuki Silalahi Arief Boediono Sri Estuningsih Deni Noviana |
| author_sort | Sitaria F. Siallagan |
| collection | DOAJ |
| description | A stable repaired fracture is the key factor responsible for the recovery of a damaged bone. The iron-based implant is one of the biodegradable metals that have been proven safe as a fracture fixation device. The objective of our experimental approach was to examine the potential of the iron-based implant as a biodegradable metal in tibia shaft fracture in sheep chronically. The samples used for this experiment were iron-based and stainless steel implants. Each had a diameter of 5 mm. These samples were analyzed through 3 phases which are material characterization, in vitro and in vivo examination. The samples were examined using a scanning electron microscope with energy dispersive spectrometer and X-ray diffraction. Based on the analysis carried out, the samples contained 90,02% and 60,81% Fe for iron-based implant and stainless implant, respectively. Both implants maintained high viability when being in contact with calf pulmonary artery endothelial cells, indicating that both implants had a minimum response to the cell in a hemocytometer and methyl tetrazolium (MTT) assay. The systemic effect of the implants was observed using hematology and blood chemistry examination. Data collection also shows that both implants also had a minimum response to the erythrocytes, leucocytes, blood chemistry, and blood mineral during the period of observation. Therefore, it could be concluded that the iron-based implant is tolerable for a period of 9 months. It also has the potential to be used as a biodegradable orthopedic implant. |
| format | Article |
| id | doaj-art-4b04b8b6b2034d4d8d5963ac763c0cc2 |
| institution | Kabale University |
| issn | 1687-8787 1687-8795 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomaterials |
| spelling | doaj-art-4b04b8b6b2034d4d8d5963ac763c0cc22025-02-03T01:02:16ZengWileyInternational Journal of Biomaterials1687-87871687-87952019-01-01201910.1155/2019/87983518798351A Wearable Iron-Based Implant as an Intramedullary Nail in Tibial Shaft Fracture of SheepSitaria F. Siallagan0Marzuki Silalahi1Arief Boediono2Sri Estuningsih3Deni Noviana4Bogor Agricultural University (IPB), Bogor 16680, IndonesiaCenter for Science and Technology of Advanced Materials (BATAN), Tangerang 15314, IndonesiaBogor Agricultural University (IPB), Bogor 16680, IndonesiaBogor Agricultural University (IPB), Bogor 16680, IndonesiaBogor Agricultural University (IPB), Bogor 16680, IndonesiaA stable repaired fracture is the key factor responsible for the recovery of a damaged bone. The iron-based implant is one of the biodegradable metals that have been proven safe as a fracture fixation device. The objective of our experimental approach was to examine the potential of the iron-based implant as a biodegradable metal in tibia shaft fracture in sheep chronically. The samples used for this experiment were iron-based and stainless steel implants. Each had a diameter of 5 mm. These samples were analyzed through 3 phases which are material characterization, in vitro and in vivo examination. The samples were examined using a scanning electron microscope with energy dispersive spectrometer and X-ray diffraction. Based on the analysis carried out, the samples contained 90,02% and 60,81% Fe for iron-based implant and stainless implant, respectively. Both implants maintained high viability when being in contact with calf pulmonary artery endothelial cells, indicating that both implants had a minimum response to the cell in a hemocytometer and methyl tetrazolium (MTT) assay. The systemic effect of the implants was observed using hematology and blood chemistry examination. Data collection also shows that both implants also had a minimum response to the erythrocytes, leucocytes, blood chemistry, and blood mineral during the period of observation. Therefore, it could be concluded that the iron-based implant is tolerable for a period of 9 months. It also has the potential to be used as a biodegradable orthopedic implant.http://dx.doi.org/10.1155/2019/8798351 |
| spellingShingle | Sitaria F. Siallagan Marzuki Silalahi Arief Boediono Sri Estuningsih Deni Noviana A Wearable Iron-Based Implant as an Intramedullary Nail in Tibial Shaft Fracture of Sheep International Journal of Biomaterials |
| title | A Wearable Iron-Based Implant as an Intramedullary Nail in Tibial Shaft Fracture of Sheep |
| title_full | A Wearable Iron-Based Implant as an Intramedullary Nail in Tibial Shaft Fracture of Sheep |
| title_fullStr | A Wearable Iron-Based Implant as an Intramedullary Nail in Tibial Shaft Fracture of Sheep |
| title_full_unstemmed | A Wearable Iron-Based Implant as an Intramedullary Nail in Tibial Shaft Fracture of Sheep |
| title_short | A Wearable Iron-Based Implant as an Intramedullary Nail in Tibial Shaft Fracture of Sheep |
| title_sort | wearable iron based implant as an intramedullary nail in tibial shaft fracture of sheep |
| url | http://dx.doi.org/10.1155/2019/8798351 |
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