Roles of Inflammasomes in Inflammatory Kidney Diseases
The immune system has a central role in eliminating detrimental factors, by frequently launching inflammatory responses towards pathogen infection and inner danger signal outbreak. Acute and chronic inflammatory responses are critical determinants for consequences of kidney diseases, in which inflam...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2019/2923072 |
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| _version_ | 1832563704177098752 |
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| author | Jinjin Fan Kaifeng Xie Liqin Wang Nuoyan Zheng Xueqing Yu |
| author_facet | Jinjin Fan Kaifeng Xie Liqin Wang Nuoyan Zheng Xueqing Yu |
| author_sort | Jinjin Fan |
| collection | DOAJ |
| description | The immune system has a central role in eliminating detrimental factors, by frequently launching inflammatory responses towards pathogen infection and inner danger signal outbreak. Acute and chronic inflammatory responses are critical determinants for consequences of kidney diseases, in which inflammasomes were inevitably involved. Inflammasomes are closely linked to many kidney diseases such as acute kidney injury and chronic kidney diseases. Inflammasomes are macromolecules consisting of multiple proteins, and their formation initiates the cleavage of procaspase-1, resulting in the activation of gasdermin D as well as the maturation and release of interleukin-1β and IL-18, leading to pyroptosis. Here, we discuss the mechanism in which inflammasomes occur, as well as their roles in inflammatory kidney diseases, in order to shed light for discovering new therapeutical targets for the prevention and treatment of inflammatory kidney diseases and consequent end-stage renal disease. |
| format | Article |
| id | doaj-art-4af984ed45414742aa8a647bafbadb69 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4af984ed45414742aa8a647bafbadb692025-02-03T01:12:50ZengWileyMediators of Inflammation0962-93511466-18612019-01-01201910.1155/2019/29230722923072Roles of Inflammasomes in Inflammatory Kidney DiseasesJinjin Fan0Kaifeng Xie1Liqin Wang2Nuoyan Zheng3Xueqing Yu4Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province 510000, ChinaGuangdong Medical University, Zhanjiang, Guangdong Province 524001, ChinaDepartment of Radiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province 510000, ChinaTranslational Medical Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province 510000, ChinaDepartment of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province 510000, ChinaThe immune system has a central role in eliminating detrimental factors, by frequently launching inflammatory responses towards pathogen infection and inner danger signal outbreak. Acute and chronic inflammatory responses are critical determinants for consequences of kidney diseases, in which inflammasomes were inevitably involved. Inflammasomes are closely linked to many kidney diseases such as acute kidney injury and chronic kidney diseases. Inflammasomes are macromolecules consisting of multiple proteins, and their formation initiates the cleavage of procaspase-1, resulting in the activation of gasdermin D as well as the maturation and release of interleukin-1β and IL-18, leading to pyroptosis. Here, we discuss the mechanism in which inflammasomes occur, as well as their roles in inflammatory kidney diseases, in order to shed light for discovering new therapeutical targets for the prevention and treatment of inflammatory kidney diseases and consequent end-stage renal disease.http://dx.doi.org/10.1155/2019/2923072 |
| spellingShingle | Jinjin Fan Kaifeng Xie Liqin Wang Nuoyan Zheng Xueqing Yu Roles of Inflammasomes in Inflammatory Kidney Diseases Mediators of Inflammation |
| title | Roles of Inflammasomes in Inflammatory Kidney Diseases |
| title_full | Roles of Inflammasomes in Inflammatory Kidney Diseases |
| title_fullStr | Roles of Inflammasomes in Inflammatory Kidney Diseases |
| title_full_unstemmed | Roles of Inflammasomes in Inflammatory Kidney Diseases |
| title_short | Roles of Inflammasomes in Inflammatory Kidney Diseases |
| title_sort | roles of inflammasomes in inflammatory kidney diseases |
| url | http://dx.doi.org/10.1155/2019/2923072 |
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