Corneal Backscatters as an Objective Index for Assessing Fuchs’ Endothelial Corneal Dystrophy: A Pilot Study
Purpose. To provide an objective, quantitative approach for monitoring Fuchs’ endothelial corneal dystrophy (FECD), with Scheimpflug imaging. Design. This is a retrospective case-control pilot study. Methods. The study group consisted of 53 eyes in 27 patients diagnosed with FECD, with normal subjec...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2017/8747013 |
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| author | Hsueh-Yen Chu Ching-Hsi Hsiao Phil Yeong-Fong Chen David Hui-Kang Ma Chee-Jen Chang Hsin-Yuan Tan |
| author_facet | Hsueh-Yen Chu Ching-Hsi Hsiao Phil Yeong-Fong Chen David Hui-Kang Ma Chee-Jen Chang Hsin-Yuan Tan |
| author_sort | Hsueh-Yen Chu |
| collection | DOAJ |
| description | Purpose. To provide an objective, quantitative approach for monitoring Fuchs’ endothelial corneal dystrophy (FECD), with Scheimpflug imaging. Design. This is a retrospective case-control pilot study. Methods. The study group consisted of 53 eyes in 27 patients diagnosed with FECD, with normal subjects paired as control. Main outcome measures were corneal thickness, morphological patterns on densitograms, and indices of corneal density including the average area density (mean AD) and the average ratio of Descemet’s membrane density versus area density (DM/AD) in Pentacam Scheimpflug images. Results. There were no significant differences in age and corneal thickness between FECD and normal groups. Morphologically, hanging-hammock patterns were noted on the densitograms of FECD patients, which were different from the high-back chair patterns in normal subjects. Quantitatively, mean AD and DM/AD were both elevated in FECD patients as compared with normal subjects (P=0.01 and 0.025, resp.). In addition, FECD patients with corneal edema had significantly higher mean AD (P=0.018) than those without corneal edema. Conclusions. This pilot study shows that Pentacam system provides an objective, quantitative way to approach FECD corneas. It can assist ophthalmologists in detecting the early change and in monitoring disease progression of FECD. Further studies are needed to consolidate the findings. |
| format | Article |
| id | doaj-art-4ade8e6e7b1a4dc0aac0294d502ae51f |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-4ade8e6e7b1a4dc0aac0294d502ae51f2025-02-03T01:04:50ZengWileyJournal of Ophthalmology2090-004X2090-00582017-01-01201710.1155/2017/87470138747013Corneal Backscatters as an Objective Index for Assessing Fuchs’ Endothelial Corneal Dystrophy: A Pilot StudyHsueh-Yen Chu0Ching-Hsi Hsiao1Phil Yeong-Fong Chen2David Hui-Kang Ma3Chee-Jen Chang4Hsin-Yuan Tan5Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, No. 5, Fuxing St., Guishan District, Taoyuan City 333, TaiwanDepartment of Ophthalmology, Chang Gung Memorial Hospital, Linkou, No. 5, Fuxing St., Guishan District, Taoyuan City 333, TaiwanDepartment of Ophthalmology, Chang Gung Memorial Hospital, Linkou, No. 5, Fuxing St., Guishan District, Taoyuan City 333, TaiwanDepartment of Ophthalmology, Chang Gung Memorial Hospital, Linkou, No. 5, Fuxing St., Guishan District, Taoyuan City 333, TaiwanGraduate Institute of Clinical Medical Science, Chang Gung University, No. 259, Wenhua 1st Rd., Guishan District, Taoyuan City 33302, TaiwanDepartment of Ophthalmology, Chang Gung Memorial Hospital, Linkou, No. 5, Fuxing St., Guishan District, Taoyuan City 333, TaiwanPurpose. To provide an objective, quantitative approach for monitoring Fuchs’ endothelial corneal dystrophy (FECD), with Scheimpflug imaging. Design. This is a retrospective case-control pilot study. Methods. The study group consisted of 53 eyes in 27 patients diagnosed with FECD, with normal subjects paired as control. Main outcome measures were corneal thickness, morphological patterns on densitograms, and indices of corneal density including the average area density (mean AD) and the average ratio of Descemet’s membrane density versus area density (DM/AD) in Pentacam Scheimpflug images. Results. There were no significant differences in age and corneal thickness between FECD and normal groups. Morphologically, hanging-hammock patterns were noted on the densitograms of FECD patients, which were different from the high-back chair patterns in normal subjects. Quantitatively, mean AD and DM/AD were both elevated in FECD patients as compared with normal subjects (P=0.01 and 0.025, resp.). In addition, FECD patients with corneal edema had significantly higher mean AD (P=0.018) than those without corneal edema. Conclusions. This pilot study shows that Pentacam system provides an objective, quantitative way to approach FECD corneas. It can assist ophthalmologists in detecting the early change and in monitoring disease progression of FECD. Further studies are needed to consolidate the findings.http://dx.doi.org/10.1155/2017/8747013 |
| spellingShingle | Hsueh-Yen Chu Ching-Hsi Hsiao Phil Yeong-Fong Chen David Hui-Kang Ma Chee-Jen Chang Hsin-Yuan Tan Corneal Backscatters as an Objective Index for Assessing Fuchs’ Endothelial Corneal Dystrophy: A Pilot Study Journal of Ophthalmology |
| title | Corneal Backscatters as an Objective Index for Assessing Fuchs’ Endothelial Corneal Dystrophy: A Pilot Study |
| title_full | Corneal Backscatters as an Objective Index for Assessing Fuchs’ Endothelial Corneal Dystrophy: A Pilot Study |
| title_fullStr | Corneal Backscatters as an Objective Index for Assessing Fuchs’ Endothelial Corneal Dystrophy: A Pilot Study |
| title_full_unstemmed | Corneal Backscatters as an Objective Index for Assessing Fuchs’ Endothelial Corneal Dystrophy: A Pilot Study |
| title_short | Corneal Backscatters as an Objective Index for Assessing Fuchs’ Endothelial Corneal Dystrophy: A Pilot Study |
| title_sort | corneal backscatters as an objective index for assessing fuchs endothelial corneal dystrophy a pilot study |
| url | http://dx.doi.org/10.1155/2017/8747013 |
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