Exome-wide association study reveals 7 functional variants associated with ex-vivo drug response in acute myeloid leukemia patients

Exome-wide association study reveals 7 functional variants associated with ex-vivo drug response in acute myeloid leukemia patients

Abstract Acute myeloid leukemia (AML) is an aggressive blood cancer characterized by poor survival outcomes. Further, due to the extreme molecular heterogeneity of the disease, drug treatment response varies from patient to patient. The variability of drug response can cause unnecessary treatment in...

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Bibliographic Details
Main Authors: Anil K. Giri, Jake Lin, Konstantinos Kyriakidis, Garima Tripathi, Henrikki Almusa
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Medical Genomics
Subjects:
CCIN
NIBAN1
Entinostat
AML
Drug response
Online Access:https://doi.org/10.1186/s12920-025-02130-7
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