Identification of a distal enhancer of Ucp1 essential for thermogenesis and mitochondrial function in brown fat

Identification of a distal enhancer of Ucp1 essential for thermogenesis and mitochondrial function in brown fat

Abstract Uncoupling protein 1 (UCP1) is a crucial protein located in the mitochondrial inner membrane that mediates nonshivering thermogenesis. However, the molecular mechanisms by which enhancer–promoter chromatin interactions control Ucp1 transcriptional regulation in brown adipose tissue (BAT) ar...

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Bibliographic Details
Main Authors: Duo Su, Tingting Jiang, Yulong Song, Die Li, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Li Li, Hongping Zhang, Linjie Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07468-3
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