Respiratory Syncytial Virus Pneumonia Treated with Lower-Dose Palivizumab in a Heart Transplant Recipient
Respiratory syncytial virus (RSV) is an important community-acquired pathogen that can cause significant morbidity and mortality in patients who have compromised pulmonary function, are elderly, or are immunosuppressed. This paper describes a 70-year-old man with a remote history of heart transplant...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Cardiology |
| Online Access: | http://dx.doi.org/10.1155/2012/723407 |
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| author | J. L. Grodin K. S. Wu E. E. Kitchell J. Le J. D. Mishkin M. H. Drazner D. W. Markham |
| author_facet | J. L. Grodin K. S. Wu E. E. Kitchell J. Le J. D. Mishkin M. H. Drazner D. W. Markham |
| author_sort | J. L. Grodin |
| collection | DOAJ |
| description | Respiratory syncytial virus (RSV) is an important community-acquired pathogen that can cause significant morbidity and mortality in patients who have compromised pulmonary function, are elderly, or are immunosuppressed. This paper describes a 70-year-old man with a remote history of heart transplantation who presented with signs and symptoms of pneumonia. Chest computed tomography (CT) imaging demonstrated new patchy ground glass infiltrates throughout the upper and lower lobes of the left lung, and the RSV direct fluorescence antibody (DFA) was positive. The patient received aerosolized ribavirin, one dose of intravenous immunoglobulin, and one dose of palivizumab. After two months of followup, the patient had improved infiltrates on chest CT, improved pulmonary function testing, and no evidence of graft rejection or dysfunction. There are few data on RSV infections in heart transplant patients, but this case highlights the importance of considering this potentially serious infection and introduces a novel method of treatment. |
| format | Article |
| id | doaj-art-4aceb67c263e443fb499441f48cb52d9 |
| institution | Kabale University |
| issn | 2090-6404 2090-6412 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Cardiology |
| spelling | doaj-art-4aceb67c263e443fb499441f48cb52d92025-02-03T05:59:52ZengWileyCase Reports in Cardiology2090-64042090-64122012-01-01201210.1155/2012/723407723407Respiratory Syncytial Virus Pneumonia Treated with Lower-Dose Palivizumab in a Heart Transplant RecipientJ. L. Grodin0K. S. Wu1E. E. Kitchell2J. Le3J. D. Mishkin4M. H. Drazner5D. W. Markham6Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USADepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USADepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USADepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USADepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USADepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USADepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USARespiratory syncytial virus (RSV) is an important community-acquired pathogen that can cause significant morbidity and mortality in patients who have compromised pulmonary function, are elderly, or are immunosuppressed. This paper describes a 70-year-old man with a remote history of heart transplantation who presented with signs and symptoms of pneumonia. Chest computed tomography (CT) imaging demonstrated new patchy ground glass infiltrates throughout the upper and lower lobes of the left lung, and the RSV direct fluorescence antibody (DFA) was positive. The patient received aerosolized ribavirin, one dose of intravenous immunoglobulin, and one dose of palivizumab. After two months of followup, the patient had improved infiltrates on chest CT, improved pulmonary function testing, and no evidence of graft rejection or dysfunction. There are few data on RSV infections in heart transplant patients, but this case highlights the importance of considering this potentially serious infection and introduces a novel method of treatment.http://dx.doi.org/10.1155/2012/723407 |
| spellingShingle | J. L. Grodin K. S. Wu E. E. Kitchell J. Le J. D. Mishkin M. H. Drazner D. W. Markham Respiratory Syncytial Virus Pneumonia Treated with Lower-Dose Palivizumab in a Heart Transplant Recipient Case Reports in Cardiology |
| title | Respiratory Syncytial Virus Pneumonia Treated with Lower-Dose Palivizumab in a Heart Transplant Recipient |
| title_full | Respiratory Syncytial Virus Pneumonia Treated with Lower-Dose Palivizumab in a Heart Transplant Recipient |
| title_fullStr | Respiratory Syncytial Virus Pneumonia Treated with Lower-Dose Palivizumab in a Heart Transplant Recipient |
| title_full_unstemmed | Respiratory Syncytial Virus Pneumonia Treated with Lower-Dose Palivizumab in a Heart Transplant Recipient |
| title_short | Respiratory Syncytial Virus Pneumonia Treated with Lower-Dose Palivizumab in a Heart Transplant Recipient |
| title_sort | respiratory syncytial virus pneumonia treated with lower dose palivizumab in a heart transplant recipient |
| url | http://dx.doi.org/10.1155/2012/723407 |
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