The Inter-Trimester Variation and Prognostic Value of Creatinine, Cystatin C and Uric Acid in Preeclamptic Patients: A Retrospective Study
Background: This study aimed to evaluate the clinical significance of maternal serum creatinine, cystatin C, and uric acid levels in relation to fetal death in pregnant women with preeclampsia. Methods: This retrospective study evaluated 708 women with preeclampsia, and 738 healthy pregnant women we...
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IMR Press
2023-02-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/50/2/10.31083/j.ceog5002043 |
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| author | Junpeng Jing Junlong Wang Gaifeng Hu Xiaofen Wei Jin Li Wanyuan Qin |
| author_facet | Junpeng Jing Junlong Wang Gaifeng Hu Xiaofen Wei Jin Li Wanyuan Qin |
| author_sort | Junpeng Jing |
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| description | Background: This study aimed to evaluate the clinical significance of maternal serum creatinine, cystatin C, and uric acid levels in relation to fetal death in pregnant women with preeclampsia. Methods: This retrospective study evaluated 708 women with preeclampsia, and 738 healthy pregnant women were selected as control. Medical records were reviewed to collect obstetric, neonatal, and biochemical data, including creatinine, cystatin C, and uric acid concentrations. Results: Maternal serum creatinine, cystatin C, and uric acid concentrations were significantly higher in the preeclamptic group than in the control (p < 0.05). Preeclamptic women in the fetal death group had significantly higher creatinine levels during their second and third trimesters, and higher uric acid concentrations throughout the pregnancy compared to the fetal survival group. Preeclamptic patients were divided into four groups based on quartiles of uric acid levels. The overall fetal survival rate in patients with upper-quartile uric acid concentrations was significantly lower than those with low uric acid levels during pregnancy. Multivariate logistic regression analysis revealed that uric acid concentration was a significant risk factor for fetal death in the first and second trimesters in the preeclamptic group (p < 0.05). Conclusions: In pregnant women with preeclampsia, fetal death was associated with upper-quartile uric acid concentrations in the first and second trimesters. Uric acid levels can be an indicator of fetal death in the early and middle stage of pregnancy. |
| format | Article |
| id | doaj-art-4abc696b7d634ca39f8af81e7087b0b8 |
| institution | OA Journals |
| issn | 0390-6663 |
| language | English |
| publishDate | 2023-02-01 |
| publisher | IMR Press |
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| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-4abc696b7d634ca39f8af81e7087b0b82025-08-20T02:17:40ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632023-02-015024310.31083/j.ceog5002043S0390-6663(22)01989-3The Inter-Trimester Variation and Prognostic Value of Creatinine, Cystatin C and Uric Acid in Preeclamptic Patients: A Retrospective StudyJunpeng Jing0Junlong Wang1Gaifeng Hu2Xiaofen Wei3Jin Li4Wanyuan Qin5Joint Inspection Center of Precision Medicine, The People’s Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, 530021 Nanning, Guangxi, ChinaDepartment of Medical Laboratory, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, 530021 Nanning, Guangxi, ChinaDepartment of Medical Laboratory, The People’s Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, 530021 Nanning, Guangxi, ChinaDepartment of Medical Laboratory, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, 530021 Nanning, Guangxi, ChinaDepartment of Medical Laboratory, First Affiliated Hospital of Zhengzhou University, 450052 Zhengzhou, Henan, ChinaDepartment of Medical Laboratory, The People’s Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, 530021 Nanning, Guangxi, ChinaBackground: This study aimed to evaluate the clinical significance of maternal serum creatinine, cystatin C, and uric acid levels in relation to fetal death in pregnant women with preeclampsia. Methods: This retrospective study evaluated 708 women with preeclampsia, and 738 healthy pregnant women were selected as control. Medical records were reviewed to collect obstetric, neonatal, and biochemical data, including creatinine, cystatin C, and uric acid concentrations. Results: Maternal serum creatinine, cystatin C, and uric acid concentrations were significantly higher in the preeclamptic group than in the control (p < 0.05). Preeclamptic women in the fetal death group had significantly higher creatinine levels during their second and third trimesters, and higher uric acid concentrations throughout the pregnancy compared to the fetal survival group. Preeclamptic patients were divided into four groups based on quartiles of uric acid levels. The overall fetal survival rate in patients with upper-quartile uric acid concentrations was significantly lower than those with low uric acid levels during pregnancy. Multivariate logistic regression analysis revealed that uric acid concentration was a significant risk factor for fetal death in the first and second trimesters in the preeclamptic group (p < 0.05). Conclusions: In pregnant women with preeclampsia, fetal death was associated with upper-quartile uric acid concentrations in the first and second trimesters. Uric acid levels can be an indicator of fetal death in the early and middle stage of pregnancy.https://www.imrpress.com/journal/CEOG/50/2/10.31083/j.ceog5002043preeclampsiacreatininecystatin curic acidfetal death |
| spellingShingle | Junpeng Jing Junlong Wang Gaifeng Hu Xiaofen Wei Jin Li Wanyuan Qin The Inter-Trimester Variation and Prognostic Value of Creatinine, Cystatin C and Uric Acid in Preeclamptic Patients: A Retrospective Study Clinical and Experimental Obstetrics & Gynecology preeclampsia creatinine cystatin c uric acid fetal death |
| title | The Inter-Trimester Variation and Prognostic Value of Creatinine, Cystatin C and Uric Acid in Preeclamptic Patients: A Retrospective Study |
| title_full | The Inter-Trimester Variation and Prognostic Value of Creatinine, Cystatin C and Uric Acid in Preeclamptic Patients: A Retrospective Study |
| title_fullStr | The Inter-Trimester Variation and Prognostic Value of Creatinine, Cystatin C and Uric Acid in Preeclamptic Patients: A Retrospective Study |
| title_full_unstemmed | The Inter-Trimester Variation and Prognostic Value of Creatinine, Cystatin C and Uric Acid in Preeclamptic Patients: A Retrospective Study |
| title_short | The Inter-Trimester Variation and Prognostic Value of Creatinine, Cystatin C and Uric Acid in Preeclamptic Patients: A Retrospective Study |
| title_sort | inter trimester variation and prognostic value of creatinine cystatin c and uric acid in preeclamptic patients a retrospective study |
| topic | preeclampsia creatinine cystatin c uric acid fetal death |
| url | https://www.imrpress.com/journal/CEOG/50/2/10.31083/j.ceog5002043 |
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