ADAMTS13 Improves Endothelial Function and Reduces Inflammation in Diabetic Retinopathy

ADAMTS13 Improves Endothelial Function and Reduces Inflammation in Diabetic Retinopathy

The protease, a disintegrin and metalloproteinase with thrombospondin type 1 motif member 13 (ADAMTS13), known to cleave only the von Willebrand factor (VWF), has powerful regulatory effects on microvascular platelet adhesion, thrombosis, inflammation, and endothelial dysfunction. We study the prote...

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Main Authors: Ahmed M. Abu El-Asrar, Mohd I. Nawaz, Ajmal Ahmad, Mairaj Siddiquei, Eef Allegaert, Lowie Adyns, Lotte Vanbrabant, Priscilla W. Gikandi, Gert De Hertogh, Sofie Struyf, Ghislain Opdenakker
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Cells
Subjects:
diabetic retinopathy
ADAMTS13
inflammation
blood–retinal barrier
Online Access:https://www.mdpi.com/2073-4409/14/2/85
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