PDPN+ cancer‐associated fibroblasts enhance gastric cancer angiogenesis via AKT/NF‐κB activation and the CCL2‐ACKR1 axis

PDPN+ cancer‐associated fibroblasts enhance gastric cancer angiogenesis via AKT/NF‐κB activation and the CCL2‐ACKR1 axis

Abstract Cancer‐associated fibroblasts (CAFs) are intrinsic components of the tumor microenvironment that promote cancer progression and metastasis. Through an unbiased integrated analysis of gastric tumor grade and stage, we identified a subset of proangiogenic CAFs characterized by high podoplanin...

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Main Authors: Zhenxiong Zhao, Hui Sun, Yingxue Liu, Yanqiu Zhang, Xin Wang, Xu Wang, Cong Tan, Shujuan Ni, Weiwei Weng, Meng Zhang, Lei Wang, Dan Huang, Wenchao Gu, Jinjia Chang, Weiqi Sheng, Mi‐die Xu
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:MedComm
Subjects:
angiogenesis
cancer‐associated fibroblasts
CCL2
gastric cancer
PDPN
Online Access:https://doi.org/10.1002/mco2.70037
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