The Relationship between Intramuscular Adipose Tissue, Functional Mobility, and Strength in Postmenopausal Women with and without Type 2 Diabetes
Objectives. To determine (1) whether intramuscular adipose tissue (IntraMAT) differs between women with and without type 2 diabetes and (2) the association between IntraMAT and mobility and strength. Methods. 59 women ≥ 65 years with and without type 2 diabetes were included. A 1-Tesla MRI was used...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.1155/2015/872726 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832552636154380288 |
|---|---|
| author | Janet M. Pritchard Sarah Karampatos Karen A. Beattie Lora M. Giangregorio George Ioannidis Stephanie A. Atkinson Lehana Thabane Hertzel Gerstein Zubin Punthakee Jonathan D. Adachi Alexandra Papaioannou |
| author_facet | Janet M. Pritchard Sarah Karampatos Karen A. Beattie Lora M. Giangregorio George Ioannidis Stephanie A. Atkinson Lehana Thabane Hertzel Gerstein Zubin Punthakee Jonathan D. Adachi Alexandra Papaioannou |
| author_sort | Janet M. Pritchard |
| collection | DOAJ |
| description | Objectives. To determine (1) whether intramuscular adipose tissue (IntraMAT) differs between women with and without type 2 diabetes and (2) the association between IntraMAT and mobility and strength. Methods. 59 women ≥ 65 years with and without type 2 diabetes were included. A 1-Tesla MRI was used to acquire images of the leg. Timed-up-and-go (TUG) and grip strength were measured. Regression was used to determine associations between the following: (1) type 2 diabetes and IntraMAT (covariates: age, ethnicity, BMI, waist : hip ratio, and energy expenditure), (2) IntraMAT and TUG (covariates: diabetes, age, BMI, and energy expenditure), and (3) IntraMAT and grip strength (covariates: diabetes, age, height, and lean mass). Results. Women with diabetes had more IntraMAT. After adjustment, IntraMAT was similar between groups (diabetes mean [SD] = 13.2 [1.4]%, controls 11.8 [1.3]%, P=0.515). IntraMAT was related to TUG and grip strength, but the relationships became nonsignificant after adjustment for covariates (difference/percent IntraMAT [95% CI]: TUG = 0.041 seconds [−0.079–0.161], P=0.498, grip strength = −0.144 kg [−0.335–0.066], P=0.175). Conclusions. IntraMAT alone may not be a clinically important predictor of functional mobility and strength; however, whether losses in functional mobility and strength are promoted by IntraMAT accumulation should be explored. |
| format | Article |
| id | doaj-art-4aaf135ab828416f85dd01615d553b5a |
| institution | Kabale University |
| issn | 2090-2204 2090-2212 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-4aaf135ab828416f85dd01615d553b5a2025-02-03T05:58:11ZengWileyJournal of Aging Research2090-22042090-22122015-01-01201510.1155/2015/872726872726The Relationship between Intramuscular Adipose Tissue, Functional Mobility, and Strength in Postmenopausal Women with and without Type 2 DiabetesJanet M. Pritchard0Sarah Karampatos1Karen A. Beattie2Lora M. Giangregorio3George Ioannidis4Stephanie A. Atkinson5Lehana Thabane6Hertzel Gerstein7Zubin Punthakee8Jonathan D. Adachi9Alexandra Papaioannou10Geriatric Education and Research in Aging Sciences (GERAS) Centre, St. Peter’s Hospital, 88 Maplewood Avenue, Hamilton, ON, L8M 1W9, CanadaGeriatric Education and Research in Aging Sciences (GERAS) Centre, St. Peter’s Hospital, 88 Maplewood Avenue, Hamilton, ON, L8M 1W9, CanadaDepartment of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, CanadaDepartment of Kinesiology, University of Waterloo, 200 University Avenue West, Waterloo, ON, N2L 3G1, CanadaGeriatric Education and Research in Aging Sciences (GERAS) Centre, St. Peter’s Hospital, 88 Maplewood Avenue, Hamilton, ON, L8M 1W9, CanadaDepartment of Pediatrics, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, CanadaDepartment of Clinical Epidemiology and Biostatistics, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, CanadaDepartment of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, CanadaDepartment of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, CanadaDepartment of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, CanadaGeriatric Education and Research in Aging Sciences (GERAS) Centre, St. Peter’s Hospital, 88 Maplewood Avenue, Hamilton, ON, L8M 1W9, CanadaObjectives. To determine (1) whether intramuscular adipose tissue (IntraMAT) differs between women with and without type 2 diabetes and (2) the association between IntraMAT and mobility and strength. Methods. 59 women ≥ 65 years with and without type 2 diabetes were included. A 1-Tesla MRI was used to acquire images of the leg. Timed-up-and-go (TUG) and grip strength were measured. Regression was used to determine associations between the following: (1) type 2 diabetes and IntraMAT (covariates: age, ethnicity, BMI, waist : hip ratio, and energy expenditure), (2) IntraMAT and TUG (covariates: diabetes, age, BMI, and energy expenditure), and (3) IntraMAT and grip strength (covariates: diabetes, age, height, and lean mass). Results. Women with diabetes had more IntraMAT. After adjustment, IntraMAT was similar between groups (diabetes mean [SD] = 13.2 [1.4]%, controls 11.8 [1.3]%, P=0.515). IntraMAT was related to TUG and grip strength, but the relationships became nonsignificant after adjustment for covariates (difference/percent IntraMAT [95% CI]: TUG = 0.041 seconds [−0.079–0.161], P=0.498, grip strength = −0.144 kg [−0.335–0.066], P=0.175). Conclusions. IntraMAT alone may not be a clinically important predictor of functional mobility and strength; however, whether losses in functional mobility and strength are promoted by IntraMAT accumulation should be explored.http://dx.doi.org/10.1155/2015/872726 |
| spellingShingle | Janet M. Pritchard Sarah Karampatos Karen A. Beattie Lora M. Giangregorio George Ioannidis Stephanie A. Atkinson Lehana Thabane Hertzel Gerstein Zubin Punthakee Jonathan D. Adachi Alexandra Papaioannou The Relationship between Intramuscular Adipose Tissue, Functional Mobility, and Strength in Postmenopausal Women with and without Type 2 Diabetes Journal of Aging Research |
| title | The Relationship between Intramuscular Adipose Tissue, Functional Mobility, and Strength in Postmenopausal Women with and without Type 2 Diabetes |
| title_full | The Relationship between Intramuscular Adipose Tissue, Functional Mobility, and Strength in Postmenopausal Women with and without Type 2 Diabetes |
| title_fullStr | The Relationship between Intramuscular Adipose Tissue, Functional Mobility, and Strength in Postmenopausal Women with and without Type 2 Diabetes |
| title_full_unstemmed | The Relationship between Intramuscular Adipose Tissue, Functional Mobility, and Strength in Postmenopausal Women with and without Type 2 Diabetes |
| title_short | The Relationship between Intramuscular Adipose Tissue, Functional Mobility, and Strength in Postmenopausal Women with and without Type 2 Diabetes |
| title_sort | relationship between intramuscular adipose tissue functional mobility and strength in postmenopausal women with and without type 2 diabetes |
| url | http://dx.doi.org/10.1155/2015/872726 |
| work_keys_str_mv | AT janetmpritchard therelationshipbetweenintramuscularadiposetissuefunctionalmobilityandstrengthinpostmenopausalwomenwithandwithouttype2diabetes AT sarahkarampatos therelationshipbetweenintramuscularadiposetissuefunctionalmobilityandstrengthinpostmenopausalwomenwithandwithouttype2diabetes AT karenabeattie therelationshipbetweenintramuscularadiposetissuefunctionalmobilityandstrengthinpostmenopausalwomenwithandwithouttype2diabetes AT loramgiangregorio therelationshipbetweenintramuscularadiposetissuefunctionalmobilityandstrengthinpostmenopausalwomenwithandwithouttype2diabetes AT georgeioannidis therelationshipbetweenintramuscularadiposetissuefunctionalmobilityandstrengthinpostmenopausalwomenwithandwithouttype2diabetes AT stephanieaatkinson therelationshipbetweenintramuscularadiposetissuefunctionalmobilityandstrengthinpostmenopausalwomenwithandwithouttype2diabetes AT lehanathabane therelationshipbetweenintramuscularadiposetissuefunctionalmobilityandstrengthinpostmenopausalwomenwithandwithouttype2diabetes AT hertzelgerstein therelationshipbetweenintramuscularadiposetissuefunctionalmobilityandstrengthinpostmenopausalwomenwithandwithouttype2diabetes AT zubinpunthakee therelationshipbetweenintramuscularadiposetissuefunctionalmobilityandstrengthinpostmenopausalwomenwithandwithouttype2diabetes AT jonathandadachi therelationshipbetweenintramuscularadiposetissuefunctionalmobilityandstrengthinpostmenopausalwomenwithandwithouttype2diabetes AT alexandrapapaioannou therelationshipbetweenintramuscularadiposetissuefunctionalmobilityandstrengthinpostmenopausalwomenwithandwithouttype2diabetes AT janetmpritchard relationshipbetweenintramuscularadiposetissuefunctionalmobilityandstrengthinpostmenopausalwomenwithandwithouttype2diabetes AT sarahkarampatos relationshipbetweenintramuscularadiposetissuefunctionalmobilityandstrengthinpostmenopausalwomenwithandwithouttype2diabetes AT karenabeattie relationshipbetweenintramuscularadiposetissuefunctionalmobilityandstrengthinpostmenopausalwomenwithandwithouttype2diabetes AT loramgiangregorio relationshipbetweenintramuscularadiposetissuefunctionalmobilityandstrengthinpostmenopausalwomenwithandwithouttype2diabetes AT georgeioannidis relationshipbetweenintramuscularadiposetissuefunctionalmobilityandstrengthinpostmenopausalwomenwithandwithouttype2diabetes AT stephanieaatkinson relationshipbetweenintramuscularadiposetissuefunctionalmobilityandstrengthinpostmenopausalwomenwithandwithouttype2diabetes AT lehanathabane relationshipbetweenintramuscularadiposetissuefunctionalmobilityandstrengthinpostmenopausalwomenwithandwithouttype2diabetes AT hertzelgerstein relationshipbetweenintramuscularadiposetissuefunctionalmobilityandstrengthinpostmenopausalwomenwithandwithouttype2diabetes AT zubinpunthakee relationshipbetweenintramuscularadiposetissuefunctionalmobilityandstrengthinpostmenopausalwomenwithandwithouttype2diabetes AT jonathandadachi relationshipbetweenintramuscularadiposetissuefunctionalmobilityandstrengthinpostmenopausalwomenwithandwithouttype2diabetes AT alexandrapapaioannou relationshipbetweenintramuscularadiposetissuefunctionalmobilityandstrengthinpostmenopausalwomenwithandwithouttype2diabetes |