Emulsion Cross-Linking Technique for Human Fibroblast Encapsulation
Microencapsulation with biodegradable polymers has potential application in drug and cell delivery systems and is currently used in probiotic delivery. In the present study, microcapsules of human fibroblast cells (CRL2522) were prepared by emulsion cross-linking technique. Tween 80 surfactant at a...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Biomaterials |
| Online Access: | http://dx.doi.org/10.1155/2018/9317878 |
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| _version_ | 1832564466695274496 |
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| author | Watcharaphong Chaemsawang Weerapong Prasongchean Konstantinos I. Papadopoulos Suchada Sukrong W. John Kao Phanphen Wattanaarsakit |
| author_facet | Watcharaphong Chaemsawang Weerapong Prasongchean Konstantinos I. Papadopoulos Suchada Sukrong W. John Kao Phanphen Wattanaarsakit |
| author_sort | Watcharaphong Chaemsawang |
| collection | DOAJ |
| description | Microencapsulation with biodegradable polymers has potential application in drug and cell delivery systems and is currently used in probiotic delivery. In the present study, microcapsules of human fibroblast cells (CRL2522) were prepared by emulsion cross-linking technique. Tween 80 surfactant at a 2% concentration through phase inversion resulted in the most efficient and stable size, morphology, and the cells survival at least 50% on day 14. Emulsion cross-linking microcapsule preparation resulted in smaller and possibly more diverse particles that can be developed clinically to deliver encapsulated mammalian cells for future disease treatments. |
| format | Article |
| id | doaj-art-4aae3e4d040d42ce8e8d1fcdf1559c1d |
| institution | Kabale University |
| issn | 1687-8787 1687-8795 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomaterials |
| spelling | doaj-art-4aae3e4d040d42ce8e8d1fcdf1559c1d2025-02-03T01:10:59ZengWileyInternational Journal of Biomaterials1687-87871687-87952018-01-01201810.1155/2018/93178789317878Emulsion Cross-Linking Technique for Human Fibroblast EncapsulationWatcharaphong Chaemsawang0Weerapong Prasongchean1Konstantinos I. Papadopoulos2Suchada Sukrong3W. John Kao4Phanphen Wattanaarsakit5Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, ThailandDepartment of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, ThailandTHAI StemLife Co., Ltd., Bangkok, ThailandDepartment of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, ThailandChemistry and Biology Centre, Li Ka Shing Faculty of Medicine and Faculty of Engineering, The University of Hong Kong, Hong Kong SAR, Hong KongDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, ThailandMicroencapsulation with biodegradable polymers has potential application in drug and cell delivery systems and is currently used in probiotic delivery. In the present study, microcapsules of human fibroblast cells (CRL2522) were prepared by emulsion cross-linking technique. Tween 80 surfactant at a 2% concentration through phase inversion resulted in the most efficient and stable size, morphology, and the cells survival at least 50% on day 14. Emulsion cross-linking microcapsule preparation resulted in smaller and possibly more diverse particles that can be developed clinically to deliver encapsulated mammalian cells for future disease treatments.http://dx.doi.org/10.1155/2018/9317878 |
| spellingShingle | Watcharaphong Chaemsawang Weerapong Prasongchean Konstantinos I. Papadopoulos Suchada Sukrong W. John Kao Phanphen Wattanaarsakit Emulsion Cross-Linking Technique for Human Fibroblast Encapsulation International Journal of Biomaterials |
| title | Emulsion Cross-Linking Technique for Human Fibroblast Encapsulation |
| title_full | Emulsion Cross-Linking Technique for Human Fibroblast Encapsulation |
| title_fullStr | Emulsion Cross-Linking Technique for Human Fibroblast Encapsulation |
| title_full_unstemmed | Emulsion Cross-Linking Technique for Human Fibroblast Encapsulation |
| title_short | Emulsion Cross-Linking Technique for Human Fibroblast Encapsulation |
| title_sort | emulsion cross linking technique for human fibroblast encapsulation |
| url | http://dx.doi.org/10.1155/2018/9317878 |
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