Intramuscular Olanzapine in the Management of Behavioral and Psychological Symptoms in Hospitalized Older Adults: A Retrospective Descriptive Study
Background. While behavioral and psychological symptoms are frequent in hospitalized older adults with dementia or delirium, data supporting the off-label use of intramuscular atypical antipsychotics remain scarce. We examined the use of short-acting intramuscular (IM) olanzapine in hospitalized old...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.1155/2015/570410 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548947239895040 |
|---|---|
| author | Silvia Duong Kam-Tong Yeung Feng Chang |
| author_facet | Silvia Duong Kam-Tong Yeung Feng Chang |
| author_sort | Silvia Duong |
| collection | DOAJ |
| description | Background. While behavioral and psychological symptoms are frequent in hospitalized older adults with dementia or delirium, data supporting the off-label use of intramuscular atypical antipsychotics remain scarce. We examined the use of short-acting intramuscular (IM) olanzapine in hospitalized older adults to manage behavioral and psychological symptoms. Methods. A retrospective observational study of inpatients 65 years or older with at least one order for olanzapine IM during admission in urban Ontario Canada was conducted. Patient demographics, prescriptions for olanzapine IM, reason for administration, perceived effectiveness, adverse events, concurrently prescribed psychotropics, comorbidities, and patient discharge destination were recorded. Results. Among 82 patients aged 65–96 years (mean ± SD 79.3 ± 7.7) 85 cases were identified. Cognitive impairment or dementia affected 63.5% and 50.6% had comorbidities. Olanzapine IM was ordered 102 times and 34 patients (41%) received at least one dose. The intended efficacy was achieved in 79.4% of 78 cases of 124 doses given (62.9%). Fourteen (41%) patients who received doses experienced adverse events, with sedation and hypotension being the most common. Conclusions. Olanzapine IM appears effective in hospitalized older adults but is associated with potential adverse events. Structured monitoring and documentation are needed to ensure safe use in this high-risk population. |
| format | Article |
| id | doaj-art-4aacf135b99f42c6800629dc6e5fd84c |
| institution | Kabale University |
| issn | 2090-2204 2090-2212 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-4aacf135b99f42c6800629dc6e5fd84c2025-02-03T06:12:32ZengWileyJournal of Aging Research2090-22042090-22122015-01-01201510.1155/2015/570410570410Intramuscular Olanzapine in the Management of Behavioral and Psychological Symptoms in Hospitalized Older Adults: A Retrospective Descriptive StudySilvia Duong0Kam-Tong Yeung1Feng Chang2North York General Hospital, 4001 Leslie Street, Toronto, ON, M2K 1E1, CanadaNorth York General Hospital, 4001 Leslie Street, Toronto, ON, M2K 1E1, CanadaNorth York General Hospital, 4001 Leslie Street, Toronto, ON, M2K 1E1, CanadaBackground. While behavioral and psychological symptoms are frequent in hospitalized older adults with dementia or delirium, data supporting the off-label use of intramuscular atypical antipsychotics remain scarce. We examined the use of short-acting intramuscular (IM) olanzapine in hospitalized older adults to manage behavioral and psychological symptoms. Methods. A retrospective observational study of inpatients 65 years or older with at least one order for olanzapine IM during admission in urban Ontario Canada was conducted. Patient demographics, prescriptions for olanzapine IM, reason for administration, perceived effectiveness, adverse events, concurrently prescribed psychotropics, comorbidities, and patient discharge destination were recorded. Results. Among 82 patients aged 65–96 years (mean ± SD 79.3 ± 7.7) 85 cases were identified. Cognitive impairment or dementia affected 63.5% and 50.6% had comorbidities. Olanzapine IM was ordered 102 times and 34 patients (41%) received at least one dose. The intended efficacy was achieved in 79.4% of 78 cases of 124 doses given (62.9%). Fourteen (41%) patients who received doses experienced adverse events, with sedation and hypotension being the most common. Conclusions. Olanzapine IM appears effective in hospitalized older adults but is associated with potential adverse events. Structured monitoring and documentation are needed to ensure safe use in this high-risk population.http://dx.doi.org/10.1155/2015/570410 |
| spellingShingle | Silvia Duong Kam-Tong Yeung Feng Chang Intramuscular Olanzapine in the Management of Behavioral and Psychological Symptoms in Hospitalized Older Adults: A Retrospective Descriptive Study Journal of Aging Research |
| title | Intramuscular Olanzapine in the Management of Behavioral and Psychological Symptoms in Hospitalized Older Adults: A Retrospective Descriptive Study |
| title_full | Intramuscular Olanzapine in the Management of Behavioral and Psychological Symptoms in Hospitalized Older Adults: A Retrospective Descriptive Study |
| title_fullStr | Intramuscular Olanzapine in the Management of Behavioral and Psychological Symptoms in Hospitalized Older Adults: A Retrospective Descriptive Study |
| title_full_unstemmed | Intramuscular Olanzapine in the Management of Behavioral and Psychological Symptoms in Hospitalized Older Adults: A Retrospective Descriptive Study |
| title_short | Intramuscular Olanzapine in the Management of Behavioral and Psychological Symptoms in Hospitalized Older Adults: A Retrospective Descriptive Study |
| title_sort | intramuscular olanzapine in the management of behavioral and psychological symptoms in hospitalized older adults a retrospective descriptive study |
| url | http://dx.doi.org/10.1155/2015/570410 |
| work_keys_str_mv | AT silviaduong intramuscularolanzapineinthemanagementofbehavioralandpsychologicalsymptomsinhospitalizedolderadultsaretrospectivedescriptivestudy AT kamtongyeung intramuscularolanzapineinthemanagementofbehavioralandpsychologicalsymptomsinhospitalizedolderadultsaretrospectivedescriptivestudy AT fengchang intramuscularolanzapineinthemanagementofbehavioralandpsychologicalsymptomsinhospitalizedolderadultsaretrospectivedescriptivestudy |