GPCRs in hypothalamic neurons and their roles in controlling food intake and metabolism
G-protein coupled receptor (GPCR) subtypes within the hypothalamus play a pivotal role in maintaining body homeostasis, particularly in the regulation of food intake and energy metabolism. This review provides an overview of classical loss and gain-of-function studies on GPCRs related to feeding and...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Molecular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2025.1536577/full |
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| author | Tian Qiu Tian Qiu Ou Fu Ou Fu |
| author_facet | Tian Qiu Tian Qiu Ou Fu Ou Fu |
| author_sort | Tian Qiu |
| collection | DOAJ |
| description | G-protein coupled receptor (GPCR) subtypes within the hypothalamus play a pivotal role in maintaining body homeostasis, particularly in the regulation of food intake and energy metabolism. This review provides an overview of classical loss and gain-of-function studies on GPCRs related to feeding and metabolism, with a focus on emerging cell-type-specific investigations. These studies reveal that diverse GPCR-expressing neuronal populations are intricately linked to feeding and energy balance. We also discuss recent findings that highlight the interaction of distinct peptide-GPCR systems in modulating complex feeding behaviors. |
| format | Article |
| id | doaj-art-4a9fd95d8eb8455fa159bb43d0f7a3f6 |
| institution | Kabale University |
| issn | 1662-5099 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj-art-4a9fd95d8eb8455fa159bb43d0f7a3f62025-02-05T07:32:24ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992025-02-011810.3389/fnmol.2025.15365771536577GPCRs in hypothalamic neurons and their roles in controlling food intake and metabolismTian Qiu0Tian Qiu1Ou Fu2Ou Fu3School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, ChinaLaboratory of Food Perception Science, Science Center for Future Foods, Jiangnan University, Wuxi, Jiangsu, ChinaSchool of Biotechnology, Jiangnan University, Wuxi, Jiangsu, ChinaLaboratory of Food Perception Science, Science Center for Future Foods, Jiangnan University, Wuxi, Jiangsu, ChinaG-protein coupled receptor (GPCR) subtypes within the hypothalamus play a pivotal role in maintaining body homeostasis, particularly in the regulation of food intake and energy metabolism. This review provides an overview of classical loss and gain-of-function studies on GPCRs related to feeding and metabolism, with a focus on emerging cell-type-specific investigations. These studies reveal that diverse GPCR-expressing neuronal populations are intricately linked to feeding and energy balance. We also discuss recent findings that highlight the interaction of distinct peptide-GPCR systems in modulating complex feeding behaviors.https://www.frontiersin.org/articles/10.3389/fnmol.2025.1536577/fullhypothalamusGPCR (G protein coupled receptor)GLP-1 receptormelanocortin receptorNPY receptorfood intake |
| spellingShingle | Tian Qiu Tian Qiu Ou Fu Ou Fu GPCRs in hypothalamic neurons and their roles in controlling food intake and metabolism Frontiers in Molecular Neuroscience hypothalamus GPCR (G protein coupled receptor) GLP-1 receptor melanocortin receptor NPY receptor food intake |
| title | GPCRs in hypothalamic neurons and their roles in controlling food intake and metabolism |
| title_full | GPCRs in hypothalamic neurons and their roles in controlling food intake and metabolism |
| title_fullStr | GPCRs in hypothalamic neurons and their roles in controlling food intake and metabolism |
| title_full_unstemmed | GPCRs in hypothalamic neurons and their roles in controlling food intake and metabolism |
| title_short | GPCRs in hypothalamic neurons and their roles in controlling food intake and metabolism |
| title_sort | gpcrs in hypothalamic neurons and their roles in controlling food intake and metabolism |
| topic | hypothalamus GPCR (G protein coupled receptor) GLP-1 receptor melanocortin receptor NPY receptor food intake |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2025.1536577/full |
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