GPCRs in hypothalamic neurons and their roles in controlling food intake and metabolism

GPCRs in hypothalamic neurons and their roles in controlling food intake and metabolism

G-protein coupled receptor (GPCR) subtypes within the hypothalamus play a pivotal role in maintaining body homeostasis, particularly in the regulation of food intake and energy metabolism. This review provides an overview of classical loss and gain-of-function studies on GPCRs related to feeding and...

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Bibliographic Details
Main Authors: Tian Qiu, Ou Fu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
hypothalamus
GPCR (G protein coupled receptor)
GLP-1 receptor
melanocortin receptor
NPY receptor
food intake
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2025.1536577/full
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Summary:G-protein coupled receptor (GPCR) subtypes within the hypothalamus play a pivotal role in maintaining body homeostasis, particularly in the regulation of food intake and energy metabolism. This review provides an overview of classical loss and gain-of-function studies on GPCRs related to feeding and metabolism, with a focus on emerging cell-type-specific investigations. These studies reveal that diverse GPCR-expressing neuronal populations are intricately linked to feeding and energy balance. We also discuss recent findings that highlight the interaction of distinct peptide-GPCR systems in modulating complex feeding behaviors.
ISSN:1662-5099

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