The Effect of Dantonic Pill on β-Catenin Expression in a Rat Model of Streptozotocin-Induced Early Stage of Diabetic Nephropathy
Diabetic nephropathy (DN) is one of the most common causes of end-stage renal failure. This study was performed to determine the effect of Dantonic Pill (DP) treatment on β-catenin expression in a rat model of streptozotocin- (STZ-) induced early-stage DN, with irbesartan treatment as a positive con...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2013/848679 |
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| author | Zhou Shuhong Lv Hongjun Cui Bo Xu Li Shi Bingyin |
| author_facet | Zhou Shuhong Lv Hongjun Cui Bo Xu Li Shi Bingyin |
| author_sort | Zhou Shuhong |
| collection | DOAJ |
| description | Diabetic nephropathy (DN) is one of the most common causes of end-stage renal failure. This study was performed to determine the effect of Dantonic Pill (DP) treatment on β-catenin expression in a rat model of streptozotocin- (STZ-) induced early-stage DN, with irbesartan treatment as a positive control. Including an analysis of the general metabolic index and renal function, immunohistochemical staining and reverse transcription real-time PCR for β-catenin were performed in the renal cortex of the rat models every 4 weeks. After the treatments of DP and irbesartan, the albuminuria level, kidney weight/body weight, and thickness of the glomerular basement membrane were decreased, but the expression of β-catenin was not downregulated in the renal cortex. The effective drug target of DP to ameliorate albuminuria and renal hypertrophy should not inhibit the upregulated expression of β-catenin in rats with STZ-induced early-stage diabetic damage. |
| format | Article |
| id | doaj-art-4a92ee6d9ec543de93dfd08e24696142 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-4a92ee6d9ec543de93dfd08e246961422025-02-03T01:03:14ZengWileyJournal of Diabetes Research2314-67452314-67532013-01-01201310.1155/2013/848679848679The Effect of Dantonic Pill on β-Catenin Expression in a Rat Model of Streptozotocin-Induced Early Stage of Diabetic NephropathyZhou Shuhong0Lv Hongjun1Cui Bo2Xu Li3Shi Bingyin4Department of Endocrinology, the First Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an 710061, ChinaDepartment of Endocrinology, the First Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an 710061, ChinaDepartment of Endocrinology, the First Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an 710061, ChinaDepartment of Endocrinology, the First Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an 710061, ChinaDepartment of Endocrinology, the First Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an 710061, ChinaDiabetic nephropathy (DN) is one of the most common causes of end-stage renal failure. This study was performed to determine the effect of Dantonic Pill (DP) treatment on β-catenin expression in a rat model of streptozotocin- (STZ-) induced early-stage DN, with irbesartan treatment as a positive control. Including an analysis of the general metabolic index and renal function, immunohistochemical staining and reverse transcription real-time PCR for β-catenin were performed in the renal cortex of the rat models every 4 weeks. After the treatments of DP and irbesartan, the albuminuria level, kidney weight/body weight, and thickness of the glomerular basement membrane were decreased, but the expression of β-catenin was not downregulated in the renal cortex. The effective drug target of DP to ameliorate albuminuria and renal hypertrophy should not inhibit the upregulated expression of β-catenin in rats with STZ-induced early-stage diabetic damage.http://dx.doi.org/10.1155/2013/848679 |
| spellingShingle | Zhou Shuhong Lv Hongjun Cui Bo Xu Li Shi Bingyin The Effect of Dantonic Pill on β-Catenin Expression in a Rat Model of Streptozotocin-Induced Early Stage of Diabetic Nephropathy Journal of Diabetes Research |
| title | The Effect of Dantonic Pill on β-Catenin Expression in a Rat Model of Streptozotocin-Induced Early Stage of Diabetic Nephropathy |
| title_full | The Effect of Dantonic Pill on β-Catenin Expression in a Rat Model of Streptozotocin-Induced Early Stage of Diabetic Nephropathy |
| title_fullStr | The Effect of Dantonic Pill on β-Catenin Expression in a Rat Model of Streptozotocin-Induced Early Stage of Diabetic Nephropathy |
| title_full_unstemmed | The Effect of Dantonic Pill on β-Catenin Expression in a Rat Model of Streptozotocin-Induced Early Stage of Diabetic Nephropathy |
| title_short | The Effect of Dantonic Pill on β-Catenin Expression in a Rat Model of Streptozotocin-Induced Early Stage of Diabetic Nephropathy |
| title_sort | effect of dantonic pill on β catenin expression in a rat model of streptozotocin induced early stage of diabetic nephropathy |
| url | http://dx.doi.org/10.1155/2013/848679 |
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