Genetic Polymorphisms: A Novel Perspective on Acute Pancreatitis
Acute pancreatitis (AP) is a complex disease that results in significant morbidity and mortality. For many decades, it has compelled researchers to explore the exact pathogenesis and the understanding of the pathogenesis of AP has progressed dramatically. Currently, premature trypsinogen activation...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2017/5135172 |
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| author | Yong Chen Chao Lian Xie Ran Hu Cheng Yi Shen Mei Zeng Chang Qiang Wu Tian Wu Chen Chen Chen Meng Yue Tang Hua Dan Xue Zheng Yu Jin Xiao Ming Zhang |
| author_facet | Yong Chen Chao Lian Xie Ran Hu Cheng Yi Shen Mei Zeng Chang Qiang Wu Tian Wu Chen Chen Chen Meng Yue Tang Hua Dan Xue Zheng Yu Jin Xiao Ming Zhang |
| author_sort | Yong Chen |
| collection | DOAJ |
| description | Acute pancreatitis (AP) is a complex disease that results in significant morbidity and mortality. For many decades, it has compelled researchers to explore the exact pathogenesis and the understanding of the pathogenesis of AP has progressed dramatically. Currently, premature trypsinogen activation and NF-κB activation for inflammation are two remarkable hypotheses for the mechanism of AP. Meanwhile, understanding of the influence of genetic polymorphisms has resulted in tremendous development in the understanding of the advancement of complex diseases. Now, genetic polymorphisms of AP have been noted gradually and many researchers devote themselves to this emerging area. In this review, we comprehensively describe genetic polymorphisms combined with the latest hypothesis of pathogenesis associated with AP. |
| format | Article |
| id | doaj-art-4a6c05cb5b914169b4597e4830235797 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-4a6c05cb5b914169b4597e48302357972025-02-03T01:32:54ZengWileyGastroenterology Research and Practice1687-61211687-630X2017-01-01201710.1155/2017/51351725135172Genetic Polymorphisms: A Novel Perspective on Acute PancreatitisYong Chen0Chao Lian Xie1Ran Hu2Cheng Yi Shen3Mei Zeng4Chang Qiang Wu5Tian Wu Chen6Chen Chen7Meng Yue Tang8Hua Dan Xue9Zheng Yu Jin10Xiao Ming Zhang11Sichuan Key Laboratory of Medical Imaging and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaSichuan Key Laboratory of Medical Imaging and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaSichuan Key Laboratory of Medical Imaging and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaSichuan Key Laboratory of Medical Imaging and Department of Pathophysiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaBiology Group, North Sichuan Medical College, Nanchong, ChinaSichuan Key Laboratory of Medical Imaging, North Sichuan Medical College, Nanchong, ChinaSichuan Key Laboratory of Medical Imaging and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaSichuan Key Laboratory of Medical Imaging and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaSichuan Key Laboratory of Medical Imaging and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaRadiology Department, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, ChinaRadiology Department, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, ChinaSichuan Key Laboratory of Medical Imaging and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaAcute pancreatitis (AP) is a complex disease that results in significant morbidity and mortality. For many decades, it has compelled researchers to explore the exact pathogenesis and the understanding of the pathogenesis of AP has progressed dramatically. Currently, premature trypsinogen activation and NF-κB activation for inflammation are two remarkable hypotheses for the mechanism of AP. Meanwhile, understanding of the influence of genetic polymorphisms has resulted in tremendous development in the understanding of the advancement of complex diseases. Now, genetic polymorphisms of AP have been noted gradually and many researchers devote themselves to this emerging area. In this review, we comprehensively describe genetic polymorphisms combined with the latest hypothesis of pathogenesis associated with AP.http://dx.doi.org/10.1155/2017/5135172 |
| spellingShingle | Yong Chen Chao Lian Xie Ran Hu Cheng Yi Shen Mei Zeng Chang Qiang Wu Tian Wu Chen Chen Chen Meng Yue Tang Hua Dan Xue Zheng Yu Jin Xiao Ming Zhang Genetic Polymorphisms: A Novel Perspective on Acute Pancreatitis Gastroenterology Research and Practice |
| title | Genetic Polymorphisms: A Novel Perspective on Acute Pancreatitis |
| title_full | Genetic Polymorphisms: A Novel Perspective on Acute Pancreatitis |
| title_fullStr | Genetic Polymorphisms: A Novel Perspective on Acute Pancreatitis |
| title_full_unstemmed | Genetic Polymorphisms: A Novel Perspective on Acute Pancreatitis |
| title_short | Genetic Polymorphisms: A Novel Perspective on Acute Pancreatitis |
| title_sort | genetic polymorphisms a novel perspective on acute pancreatitis |
| url | http://dx.doi.org/10.1155/2017/5135172 |
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