Study of Body Composition and Metabolic Parameters in HIV-1 Male Patients
Background. HIV patients on highly active antiretroviral therapy (HAART) containing protease inhibitors (PIs) had been often associated with lipodystrophy. However, there are only few studies on association of nucleoside and nonnucleoside reverse transcriptase inhibitors (NRTI and NNRTI) with lipody...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2014/498497 |
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| author | Gurudath Gundurao Sreekantamurthy N Biplab Singh Th Bhimo Singh Th Suraj Singh Karam Romeo Singh |
| author_facet | Gurudath Gundurao Sreekantamurthy N Biplab Singh Th Bhimo Singh Th Suraj Singh Karam Romeo Singh |
| author_sort | Gurudath Gundurao Sreekantamurthy |
| collection | DOAJ |
| description | Background. HIV patients on highly active antiretroviral therapy (HAART) containing protease inhibitors (PIs) had been often associated with lipodystrophy. However, there are only few studies on association of nucleoside and nonnucleoside reverse transcriptase inhibitors (NRTI and NNRTI) with lipodystrophy. Study Design. One hundred and one HIV male patients were categorised into ART naïve (n=22), zidovudine (n=22), stavudine (n=18), tenofovir (n=15), and PIs (n=24) based HAART. Their clinicoepidemiological data had been entered in preformed pro forma. The body composition, using TANITA machine and metabolic parameters like lipid profile, blood sugars was analysed. Results. Clinically, lipoatrophy of face was most prevalent in HIV patients on stavudine (15 patients, 83.3%) and PIs (20 patients, 83.3%) based HAART. The mean BMI among study population was in normal range. Excess visceral fat was most prevalent among patients on PIs, 4 patients (16.7%). The waist-hip ratio was significantly higher in PIs (P=0.01) based HAART. There was no significant difference among different study populations in terms of BMI (P=0.917), body water (P=0.318), body fat (P=0.172), bone mass (P=0.200), and muscle mass (P=0.070). Hypertriglyceridiemia was found in stavudine, tenofovir, and protease inhibitors regimens. Low levels of high density lipoprotein (HDL) was found zidovudine, stavudine, and PIs regimens. Fasting and postprandial hyperglycaemia was found PIs and impaired glucose tolerance in stavudine regimen. Conclusion. Patients on PIs were associated with truncal obesity and lipoatrophy of face, along with dyslipidemia and hyperglycaemia. Stavudine based regimen is associated with hypertriglyceridiemia and low HDL along with lipoatrophy of face. |
| format | Article |
| id | doaj-art-4a53891e03fb41fa988ce01b1045f4e1 |
| institution | Kabale University |
| issn | 2090-0724 2090-0732 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-4a53891e03fb41fa988ce01b1045f4e12025-02-03T06:11:00ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322014-01-01201410.1155/2014/498497498497Study of Body Composition and Metabolic Parameters in HIV-1 Male PatientsGurudath Gundurao Sreekantamurthy0N Biplab Singh1Th Bhimo Singh2Th Suraj Singh3Karam Romeo Singh4Department of General Medicine, Regional Institute of Medical Sciences, Imphal 795004, IndiaDepartment of General Medicine, Regional Institute of Medical Sciences, Imphal 795004, IndiaDepartment of General Medicine, Regional Institute of Medical Sciences, Imphal 795004, IndiaDepartment of General Medicine, Regional Institute of Medical Sciences, Imphal 795004, IndiaDepartment of General Medicine, Regional Institute of Medical Sciences, Imphal 795004, IndiaBackground. HIV patients on highly active antiretroviral therapy (HAART) containing protease inhibitors (PIs) had been often associated with lipodystrophy. However, there are only few studies on association of nucleoside and nonnucleoside reverse transcriptase inhibitors (NRTI and NNRTI) with lipodystrophy. Study Design. One hundred and one HIV male patients were categorised into ART naïve (n=22), zidovudine (n=22), stavudine (n=18), tenofovir (n=15), and PIs (n=24) based HAART. Their clinicoepidemiological data had been entered in preformed pro forma. The body composition, using TANITA machine and metabolic parameters like lipid profile, blood sugars was analysed. Results. Clinically, lipoatrophy of face was most prevalent in HIV patients on stavudine (15 patients, 83.3%) and PIs (20 patients, 83.3%) based HAART. The mean BMI among study population was in normal range. Excess visceral fat was most prevalent among patients on PIs, 4 patients (16.7%). The waist-hip ratio was significantly higher in PIs (P=0.01) based HAART. There was no significant difference among different study populations in terms of BMI (P=0.917), body water (P=0.318), body fat (P=0.172), bone mass (P=0.200), and muscle mass (P=0.070). Hypertriglyceridiemia was found in stavudine, tenofovir, and protease inhibitors regimens. Low levels of high density lipoprotein (HDL) was found zidovudine, stavudine, and PIs regimens. Fasting and postprandial hyperglycaemia was found PIs and impaired glucose tolerance in stavudine regimen. Conclusion. Patients on PIs were associated with truncal obesity and lipoatrophy of face, along with dyslipidemia and hyperglycaemia. Stavudine based regimen is associated with hypertriglyceridiemia and low HDL along with lipoatrophy of face.http://dx.doi.org/10.1155/2014/498497 |
| spellingShingle | Gurudath Gundurao Sreekantamurthy N Biplab Singh Th Bhimo Singh Th Suraj Singh Karam Romeo Singh Study of Body Composition and Metabolic Parameters in HIV-1 Male Patients Journal of Nutrition and Metabolism |
| title | Study of Body Composition and Metabolic Parameters in HIV-1 Male Patients |
| title_full | Study of Body Composition and Metabolic Parameters in HIV-1 Male Patients |
| title_fullStr | Study of Body Composition and Metabolic Parameters in HIV-1 Male Patients |
| title_full_unstemmed | Study of Body Composition and Metabolic Parameters in HIV-1 Male Patients |
| title_short | Study of Body Composition and Metabolic Parameters in HIV-1 Male Patients |
| title_sort | study of body composition and metabolic parameters in hiv 1 male patients |
| url | http://dx.doi.org/10.1155/2014/498497 |
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