A Multidisciplinary Approach to the Management of Atypical Osseous Epithelioid Hemangioendothelioma
Hemangioendothelioma is a rare vascular tumor of intermediate malignant potential. Though epithelioid hemangioendothelioma (EH) is commonly found in soft tissues, it has been known to be present in skeletal tissues. The authors present a case of a 50-year-old woman diagnosed with EH of the iliac bo...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2014/917425 |
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| author | J. K. Ma J. Barr S. Vijayakumar |
| author_facet | J. K. Ma J. Barr S. Vijayakumar |
| author_sort | J. K. Ma |
| collection | DOAJ |
| description | Hemangioendothelioma is a rare vascular tumor of intermediate malignant potential. Though epithelioid hemangioendothelioma (EH) is commonly found in soft tissues, it has been known to be present in skeletal tissues. The authors present a case of a 50-year-old woman diagnosed with EH of the iliac bone and acetabulum, who experienced pathological fracture at presentation. This report describes a multidisciplinary approach to the management that includes initial incisional biopsy, curettage, and bone grafting, followed by Intensity Modulated Radiation Therapy. The patient finally underwent hemipelvic resection with allograft reconstruction after recurrence. Histopathological study revealed osseous EH of low mitotic activity that stained positively for CD31, CD34, vimentin, and Factor VIII. Herein, the authors discuss the imaging characteristics, histopathological aspects, cytogenetic findings, and the radiobiological behavior of osseous EH. After an aggressive multidisciplinary intervention, the patient is able to achieve local control with no evidence of distal metastatic disease. |
| format | Article |
| id | doaj-art-4a517948bb9f49a4858f4f6424dea0a9 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-4a517948bb9f49a4858f4f6424dea0a92025-02-03T01:01:17ZengWileyCase Reports in Oncological Medicine2090-67062090-67142014-01-01201410.1155/2014/917425917425A Multidisciplinary Approach to the Management of Atypical Osseous Epithelioid HemangioendotheliomaJ. K. Ma0J. Barr1S. Vijayakumar2Department of Radiation Oncology, University of Mississippi Medical Center, 350 Woodrow Wilson Drive, Suite 1600, Jackson, MS 39213, USADepartment of Orthopedics Surgery, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USADepartment of Radiation Oncology, University of Mississippi Medical Center, 350 Woodrow Wilson Drive, Suite 1600, Jackson, MS 39213, USAHemangioendothelioma is a rare vascular tumor of intermediate malignant potential. Though epithelioid hemangioendothelioma (EH) is commonly found in soft tissues, it has been known to be present in skeletal tissues. The authors present a case of a 50-year-old woman diagnosed with EH of the iliac bone and acetabulum, who experienced pathological fracture at presentation. This report describes a multidisciplinary approach to the management that includes initial incisional biopsy, curettage, and bone grafting, followed by Intensity Modulated Radiation Therapy. The patient finally underwent hemipelvic resection with allograft reconstruction after recurrence. Histopathological study revealed osseous EH of low mitotic activity that stained positively for CD31, CD34, vimentin, and Factor VIII. Herein, the authors discuss the imaging characteristics, histopathological aspects, cytogenetic findings, and the radiobiological behavior of osseous EH. After an aggressive multidisciplinary intervention, the patient is able to achieve local control with no evidence of distal metastatic disease.http://dx.doi.org/10.1155/2014/917425 |
| spellingShingle | J. K. Ma J. Barr S. Vijayakumar A Multidisciplinary Approach to the Management of Atypical Osseous Epithelioid Hemangioendothelioma Case Reports in Oncological Medicine |
| title | A Multidisciplinary Approach to the Management of Atypical Osseous Epithelioid Hemangioendothelioma |
| title_full | A Multidisciplinary Approach to the Management of Atypical Osseous Epithelioid Hemangioendothelioma |
| title_fullStr | A Multidisciplinary Approach to the Management of Atypical Osseous Epithelioid Hemangioendothelioma |
| title_full_unstemmed | A Multidisciplinary Approach to the Management of Atypical Osseous Epithelioid Hemangioendothelioma |
| title_short | A Multidisciplinary Approach to the Management of Atypical Osseous Epithelioid Hemangioendothelioma |
| title_sort | multidisciplinary approach to the management of atypical osseous epithelioid hemangioendothelioma |
| url | http://dx.doi.org/10.1155/2014/917425 |
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