ProteotoxomiRs: Diagnostic and pathologic miRNA signatures for reductive stress induced proteotoxic heart disease

ProteotoxomiRs: Diagnostic and pathologic miRNA signatures for reductive stress induced proteotoxic heart disease

Proteotoxic stress progressively leads to irreversible cardiac abnormalities. Using a mouse model of reductive stress-induced proteotoxic cardiomyopathy, we identified novel microRNA signatures, termed “ProteotoxomiRs,” which reflect stage-specific and transgene-specific responses to proteotoxic str...

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Bibliographic Details
Main Authors: Santhosh Kumar Karthikeyan, Palanisamy Nallasamy, Jarrell Matthew Cleveland, Ahila Arulmani, Ashvanthi Raveendran, Mariam Karimi, Mohammad Owais Ansari, Anil Kumar Challa, Moorthy P. Ponnusamy, Ivor J. Benjamin, Sooryanarayana Varambally, Namakkal S. Rajasekaran
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Redox Biology
Subjects:
Protein aggregation
miRNA
Reductive stress
Cardiomyopathy
ProteotoxomiRs
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725000382
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