The Influence of Alcohol Consumption in Conjunction with Sex Hormone Deficiency on Ca/P Ratio in Rats
Deficiency of sex hormones and excessive alcohol consumption are factors that have been related to alterations in the pattern of bone mineralization and osteoporosis. The aim of this study was to evaluate possible alterations in the calcium/phosphorus (Ca/P) ratio in the femur of rats subjected to s...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/3797139 |
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| author | Karina Bortolin Lodi Adriana Mathias Pereira da Silva Marchini Ana Maria do Espírito Santo Sigmar de Mello Rode Leonardo Marchini Rosilene Fernandes da Rocha |
| author_facet | Karina Bortolin Lodi Adriana Mathias Pereira da Silva Marchini Ana Maria do Espírito Santo Sigmar de Mello Rode Leonardo Marchini Rosilene Fernandes da Rocha |
| author_sort | Karina Bortolin Lodi |
| collection | DOAJ |
| description | Deficiency of sex hormones and excessive alcohol consumption are factors that have been related to alterations in the pattern of bone mineralization and osteoporosis. The aim of this study was to evaluate possible alterations in the calcium/phosphorus (Ca/P) ratio in the femur of rats subjected to sex hormone deficiency and/or alcohol consumption. Methods. Female and male Wistar rats (n=108) were divided into ovariectomized (Ovx), orchiectomized (Orx), or sham-operated groups and subdivided according to diet: alcoholic diet (20% alcohol solution), isocaloric diet, and ad libitum diet. The diets were administered for 8 weeks. The Ca/P ratio in the femur was analyzed by energy dispersive micro-X-ray spectrometer (μEDX). Results. Consumption of alcohol reduced the Ca/P ratio in both females and males. The isocaloric diet reduced the Ca/P ratio in females. In groups with the ad libitum diet, the deficiency of sex hormones did not change the Ca/P ratio in females or males. However, the combination of sex hormone deficiency and alcoholic diet presented the lowest values for the Ca/P ratio in both females and males. Conclusions. There was a reduced Ca/P ratio in the femur of rats that consumed alcohol, which was exacerbated when combined with a deficiency of sex hormones. |
| format | Article |
| id | doaj-art-4a30200ab50842299f58a76dccc0206c |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-4a30200ab50842299f58a76dccc0206c2025-02-03T01:04:51ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/37971393797139The Influence of Alcohol Consumption in Conjunction with Sex Hormone Deficiency on Ca/P Ratio in RatsKarina Bortolin Lodi0Adriana Mathias Pereira da Silva Marchini1Ana Maria do Espírito Santo2Sigmar de Mello Rode3Leonardo Marchini4Rosilene Fernandes da Rocha5Institute of Science and Technology, Department of Biosciences and Diagnostics, Universidade Estadual Paulista (UNESP), Avenida Engenheiro Francisco José Longo 777, 12245-000 São José dos Campos, SP, BrazilInstitute of Science and Technology, Department of Biosciences and Diagnostics, Universidade Estadual Paulista (UNESP), Avenida Engenheiro Francisco José Longo 777, 12245-000 São José dos Campos, SP, BrazilInstitute of Environmental Science, Chemical and Pharmaceutical, Department of Mathematical and Earth Sciences, Federal University of São Paulo (UNIFESP), Rua Prof. Artur Riedel 275, 09972-270 Diadema, SP, BrazilInstitute of Science and Technology, Department of Dental Materials and Prosthesis, Universidade Estadual Paulista (UNESP), Avenida Engenheiro Francisco José Longo 777, 12245-000 São José dos Campos, SP, BrazilDepartment of Preventive and Community Dentistry, The University of Iowa College of Dentistry and Dental Clinics, N337-1 Dental Science N, 52242 Iowa City, IA, USAInstitute of Science and Technology, Department of Biosciences and Diagnostics, Universidade Estadual Paulista (UNESP), Avenida Engenheiro Francisco José Longo 777, 12245-000 São José dos Campos, SP, BrazilDeficiency of sex hormones and excessive alcohol consumption are factors that have been related to alterations in the pattern of bone mineralization and osteoporosis. The aim of this study was to evaluate possible alterations in the calcium/phosphorus (Ca/P) ratio in the femur of rats subjected to sex hormone deficiency and/or alcohol consumption. Methods. Female and male Wistar rats (n=108) were divided into ovariectomized (Ovx), orchiectomized (Orx), or sham-operated groups and subdivided according to diet: alcoholic diet (20% alcohol solution), isocaloric diet, and ad libitum diet. The diets were administered for 8 weeks. The Ca/P ratio in the femur was analyzed by energy dispersive micro-X-ray spectrometer (μEDX). Results. Consumption of alcohol reduced the Ca/P ratio in both females and males. The isocaloric diet reduced the Ca/P ratio in females. In groups with the ad libitum diet, the deficiency of sex hormones did not change the Ca/P ratio in females or males. However, the combination of sex hormone deficiency and alcoholic diet presented the lowest values for the Ca/P ratio in both females and males. Conclusions. There was a reduced Ca/P ratio in the femur of rats that consumed alcohol, which was exacerbated when combined with a deficiency of sex hormones.http://dx.doi.org/10.1155/2016/3797139 |
| spellingShingle | Karina Bortolin Lodi Adriana Mathias Pereira da Silva Marchini Ana Maria do Espírito Santo Sigmar de Mello Rode Leonardo Marchini Rosilene Fernandes da Rocha The Influence of Alcohol Consumption in Conjunction with Sex Hormone Deficiency on Ca/P Ratio in Rats International Journal of Endocrinology |
| title | The Influence of Alcohol Consumption in Conjunction with Sex Hormone Deficiency on Ca/P Ratio in Rats |
| title_full | The Influence of Alcohol Consumption in Conjunction with Sex Hormone Deficiency on Ca/P Ratio in Rats |
| title_fullStr | The Influence of Alcohol Consumption in Conjunction with Sex Hormone Deficiency on Ca/P Ratio in Rats |
| title_full_unstemmed | The Influence of Alcohol Consumption in Conjunction with Sex Hormone Deficiency on Ca/P Ratio in Rats |
| title_short | The Influence of Alcohol Consumption in Conjunction with Sex Hormone Deficiency on Ca/P Ratio in Rats |
| title_sort | influence of alcohol consumption in conjunction with sex hormone deficiency on ca p ratio in rats |
| url | http://dx.doi.org/10.1155/2016/3797139 |
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