Two Synchronous Neonatal Tumors: An Extremely Rare Case
We report a case of a newborn with two synchronous tumors—sialoblastoma and hepatoblastoma—diagnosed at 20 weeks of gestation by magnetic resonance imaging (MRI) and ultrasonography (US). The aim of this study was to describe the management of this case together with a review of the literature. Our...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2021/6674372 |
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| author | M. Rodríguez-Zubieta K. Albarenque C. Lagues A. San Roman M. Varela D. Russo G. Podesta D. Steinberg C. Schauvinhold A. Etchegaray M. T. G. de Dávila |
| author_facet | M. Rodríguez-Zubieta K. Albarenque C. Lagues A. San Roman M. Varela D. Russo G. Podesta D. Steinberg C. Schauvinhold A. Etchegaray M. T. G. de Dávila |
| author_sort | M. Rodríguez-Zubieta |
| collection | DOAJ |
| description | We report a case of a newborn with two synchronous tumors—sialoblastoma and hepatoblastoma—diagnosed at 20 weeks of gestation by magnetic resonance imaging (MRI) and ultrasonography (US). The aim of this study was to describe the management of this case together with a review of the literature. Our patient had a large facial tumor associated with extremely high alpha-fetoprotein levels. Diagnosis of the tumors was made by surgical biopsy, showing typical features in both. Sialoblastoma is a potentially aggressive tumor. In our case, the Ki67 index in the sialoblastoma was between 20 and 30%, indicating a possibly unfavorable behavior. The infant underwent surgery and chemotherapy in different steps. Complete surgical resection with clean margins is considered to be the best treatment option for sialoblastoma. Only four similar cases were previously reported. Timely management by a multidisciplinary team is essential in these difficult cases. In our patient, outcome was good at the time of this report. |
| format | Article |
| id | doaj-art-4a1f0747a54341ebbe7c738285263119 |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-4a1f0747a54341ebbe7c7382852631192025-02-03T01:09:57ZengWileyCase Reports in Pathology2090-67812090-679X2021-01-01202110.1155/2021/66743726674372Two Synchronous Neonatal Tumors: An Extremely Rare CaseM. Rodríguez-Zubieta0K. Albarenque1C. Lagues2A. San Roman3M. Varela4D. Russo5G. Podesta6D. Steinberg7C. Schauvinhold8A. Etchegaray9M. T. G. de Dávila10Department of Pathology, Hospital Universitario Austral, Buenos Aires, ArgentinaDepartment of Pathology, Hospital Universitario Austral, Buenos Aires, ArgentinaDepartment of Pathology, Hospital Universitario Austral, Buenos Aires, ArgentinaDepartment of Pathology, Hospital Universitario Austral, Buenos Aires, ArgentinaDepartment of Oncology, Hospital Universitario Austral, Buenos Aires, ArgentinaDepartment of Pediatric Surgery, Hospital Universitario Austral, Buenos Aires, ArgentinaDepartment of Liver Surgery and Transplantation, Hospital Universitario Austral, Buenos Aires, ArgentinaDepartment of Plastic Surgery, Hospital Universitario Austral, Buenos Aires, ArgentinaDepartment of Plastic Surgery, Hospital Universitario Austral, Buenos Aires, ArgentinaFetal Medicine Unit, Hospital Universitario Austral, Buenos Aires, ArgentinaDepartment of Pathology, Hospital Universitario Austral, Buenos Aires, ArgentinaWe report a case of a newborn with two synchronous tumors—sialoblastoma and hepatoblastoma—diagnosed at 20 weeks of gestation by magnetic resonance imaging (MRI) and ultrasonography (US). The aim of this study was to describe the management of this case together with a review of the literature. Our patient had a large facial tumor associated with extremely high alpha-fetoprotein levels. Diagnosis of the tumors was made by surgical biopsy, showing typical features in both. Sialoblastoma is a potentially aggressive tumor. In our case, the Ki67 index in the sialoblastoma was between 20 and 30%, indicating a possibly unfavorable behavior. The infant underwent surgery and chemotherapy in different steps. Complete surgical resection with clean margins is considered to be the best treatment option for sialoblastoma. Only four similar cases were previously reported. Timely management by a multidisciplinary team is essential in these difficult cases. In our patient, outcome was good at the time of this report.http://dx.doi.org/10.1155/2021/6674372 |
| spellingShingle | M. Rodríguez-Zubieta K. Albarenque C. Lagues A. San Roman M. Varela D. Russo G. Podesta D. Steinberg C. Schauvinhold A. Etchegaray M. T. G. de Dávila Two Synchronous Neonatal Tumors: An Extremely Rare Case Case Reports in Pathology |
| title | Two Synchronous Neonatal Tumors: An Extremely Rare Case |
| title_full | Two Synchronous Neonatal Tumors: An Extremely Rare Case |
| title_fullStr | Two Synchronous Neonatal Tumors: An Extremely Rare Case |
| title_full_unstemmed | Two Synchronous Neonatal Tumors: An Extremely Rare Case |
| title_short | Two Synchronous Neonatal Tumors: An Extremely Rare Case |
| title_sort | two synchronous neonatal tumors an extremely rare case |
| url | http://dx.doi.org/10.1155/2021/6674372 |
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