Retrospective Analysis of Penicillin G Minimum Inhibitory Concentration for Gram-Positive Isolates of Non-Severe Clinical Mastitis
<b>Background</b>: Despite penicillin having a longstanding reputation as being scientifically approved for the treatment of bovine mastitis, its market share and practical application rate seem rather low. While in some countries, cases of mild and moderate mastitis are treated almost c...
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MDPI AG
2025-01-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/14/1/21 |
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| author | Stefanie Leimbach Franziska Nankemann Anne Tellen Doris Klocke Nicole Wente Yanchao Zhang Volker Krömker |
| author_facet | Stefanie Leimbach Franziska Nankemann Anne Tellen Doris Klocke Nicole Wente Yanchao Zhang Volker Krömker |
| author_sort | Stefanie Leimbach |
| collection | DOAJ |
| description | <b>Background</b>: Despite penicillin having a longstanding reputation as being scientifically approved for the treatment of bovine mastitis, its market share and practical application rate seem rather low. While in some countries, cases of mild and moderate mastitis are treated almost completely with simple penicillin, in other countries, penicillin is rarely used as a mono-substance in udder tubes. <b>Methods</b>: Based on minimal inhibitory concentration (MIC) studies of 1489 isolates of Gram-positive microorganisms isolated from bovine mastitis cases, the extent to which penicillin preparations can fulfil their role as first-line treatment and in how many cases insufficient efficacy must be assumed was assessed in comparison with more recent studies on the achievable levels of active substances in milk. <b>Results</b>: Of the isolates, 76% had an MIC of ≤0.125 µg/mL and 95% of the isolates had an MIC of ≤1 µg/mL. <b>Conclusions</b>: The data show that in Northern Germany, it can be assumed that penicillin is a good choice in most cases of mastitis caused by Gram-positive mastitis pathogens, at least from the perspective of antibiotic resistance. |
| format | Article |
| id | doaj-art-49f66f4b9c5c4d91a434ed9c032c2199 |
| institution | Kabale University |
| issn | 2079-6382 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Antibiotics |
| spelling | doaj-art-49f66f4b9c5c4d91a434ed9c032c21992025-01-24T13:18:34ZengMDPI AGAntibiotics2079-63822025-01-011412110.3390/antibiotics14010021Retrospective Analysis of Penicillin G Minimum Inhibitory Concentration for Gram-Positive Isolates of Non-Severe Clinical MastitisStefanie Leimbach0Franziska Nankemann1Anne Tellen2Doris Klocke3Nicole Wente4Yanchao Zhang5Volker Krömker6Department of Microbiology, Faculty of Mechanical and Bioprocess Engineering, University of Applied Sciences and Arts, 30453 Hannover, GermanyDepartment of Microbiology, Faculty of Mechanical and Bioprocess Engineering, University of Applied Sciences and Arts, 30453 Hannover, GermanyDepartment of Microbiology, Faculty of Mechanical and Bioprocess Engineering, University of Applied Sciences and Arts, 30453 Hannover, GermanyDepartment of Microbiology, Faculty of Mechanical and Bioprocess Engineering, University of Applied Sciences and Arts, 30453 Hannover, GermanyDepartment of Microbiology, Faculty of Mechanical and Bioprocess Engineering, University of Applied Sciences and Arts, 30453 Hannover, GermanyDepartment of Microbiology, Faculty of Mechanical and Bioprocess Engineering, University of Applied Sciences and Arts, 30453 Hannover, GermanyDepartment of Microbiology, Faculty of Mechanical and Bioprocess Engineering, University of Applied Sciences and Arts, 30453 Hannover, Germany<b>Background</b>: Despite penicillin having a longstanding reputation as being scientifically approved for the treatment of bovine mastitis, its market share and practical application rate seem rather low. While in some countries, cases of mild and moderate mastitis are treated almost completely with simple penicillin, in other countries, penicillin is rarely used as a mono-substance in udder tubes. <b>Methods</b>: Based on minimal inhibitory concentration (MIC) studies of 1489 isolates of Gram-positive microorganisms isolated from bovine mastitis cases, the extent to which penicillin preparations can fulfil their role as first-line treatment and in how many cases insufficient efficacy must be assumed was assessed in comparison with more recent studies on the achievable levels of active substances in milk. <b>Results</b>: Of the isolates, 76% had an MIC of ≤0.125 µg/mL and 95% of the isolates had an MIC of ≤1 µg/mL. <b>Conclusions</b>: The data show that in Northern Germany, it can be assumed that penicillin is a good choice in most cases of mastitis caused by Gram-positive mastitis pathogens, at least from the perspective of antibiotic resistance.https://www.mdpi.com/2079-6382/14/1/21minimal inhibitory concentrationantimicrobial susceptibilityGram-positive mastitis pathogensprocaine benzylpenicillin |
| spellingShingle | Stefanie Leimbach Franziska Nankemann Anne Tellen Doris Klocke Nicole Wente Yanchao Zhang Volker Krömker Retrospective Analysis of Penicillin G Minimum Inhibitory Concentration for Gram-Positive Isolates of Non-Severe Clinical Mastitis Antibiotics minimal inhibitory concentration antimicrobial susceptibility Gram-positive mastitis pathogens procaine benzylpenicillin |
| title | Retrospective Analysis of Penicillin G Minimum Inhibitory Concentration for Gram-Positive Isolates of Non-Severe Clinical Mastitis |
| title_full | Retrospective Analysis of Penicillin G Minimum Inhibitory Concentration for Gram-Positive Isolates of Non-Severe Clinical Mastitis |
| title_fullStr | Retrospective Analysis of Penicillin G Minimum Inhibitory Concentration for Gram-Positive Isolates of Non-Severe Clinical Mastitis |
| title_full_unstemmed | Retrospective Analysis of Penicillin G Minimum Inhibitory Concentration for Gram-Positive Isolates of Non-Severe Clinical Mastitis |
| title_short | Retrospective Analysis of Penicillin G Minimum Inhibitory Concentration for Gram-Positive Isolates of Non-Severe Clinical Mastitis |
| title_sort | retrospective analysis of penicillin g minimum inhibitory concentration for gram positive isolates of non severe clinical mastitis |
| topic | minimal inhibitory concentration antimicrobial susceptibility Gram-positive mastitis pathogens procaine benzylpenicillin |
| url | https://www.mdpi.com/2079-6382/14/1/21 |
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