Endothelial cells under disturbed flow release extracellular vesicles to promote inflammatory polarization of macrophages and accelerate atherosclerosis

Endothelial cells under disturbed flow release extracellular vesicles to promote inflammatory polarization of macrophages and accelerate atherosclerosis

Abstract Background Extracellular vesicles (EVs) derived from endothelial cells (ECs) are increasingly recognized for their role in the initiation and progression of atherosclerosis. ECs experience varying degrees and types of blood flow depending on their specific arterial locations. In regions of...

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Bibliographic Details
Main Authors: Zhe Hou, Li Deng, Fei Fang, Ting Zhao, Yaojia Zhang, Gang Li, Michael Z. Miao, Yongcang Zhang, Hongchi Yu, Xiaoheng Liu
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Biology
Subjects:
Disturbed flow
Endothelial cells
Extracellular vesicle
Macrophages
Atherosclerosis
Online Access:https://doi.org/10.1186/s12915-025-02125-x
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