Chlamydia pneumoniae-Mediated Inflammation in Atherosclerosis: A Meta-Analysis
Several studies have attempted to relate the C. pneumoniae-mediated inflammatory state with atherosclerotic cardiovascular diseases, providing inconsistent results. Therefore, we performed a meta-analysis to clarify whether C. pneumoniae may contribute to the pathogenesis of atherosclerosis by enhan...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/378658 |
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| author | Simone Filardo Marisa Di Pietro Alessio Farcomeni Giovanna Schiavoni Rosa Sessa |
| author_facet | Simone Filardo Marisa Di Pietro Alessio Farcomeni Giovanna Schiavoni Rosa Sessa |
| author_sort | Simone Filardo |
| collection | DOAJ |
| description | Several studies have attempted to relate the C. pneumoniae-mediated inflammatory state with atherosclerotic cardiovascular diseases, providing inconsistent results. Therefore, we performed a meta-analysis to clarify whether C. pneumoniae may contribute to the pathogenesis of atherosclerosis by enhancing inflammation. 12 case-control, 6 cross-sectional, and 7 prospective studies with a total of 10,176 patients have been included in this meta-analysis. Odds Ratio (OR) with a 95% confidence interval was used to assess the seroprevalence of C. pneumoniae and differences between levels of inflammatory markers were assessed by standard mean differences. Publication bias was performed to ensure the statistical power. hsCRP, fibrinogen, interleukin- (IL-) 6, TNF-α, and IFN-γ showed a significant increase in patients with atherosclerosis compared to healthy controls (P<0.05), along with a higher seroprevalence of C. pneumoniae (OR of 3.11, 95% CI: 2.88–3.36, P<0.001). More interestingly, hsCRP, IL-6, and fibrinogen levels were significantly higher in C. pneumoniae IgA seropositive compared to seronegative atherosclerotic patients (P<0.0001). In conclusion, the present meta-analysis suggests that C. pneumoniae infection may contribute to atherosclerotic cardiovascular diseases by enhancing the inflammatory state, and, in particular, seropositivity to C. pneumoniae IgA, together with hsCRP, fibrinogen, and IL-6, may be predictive of atherosclerotic cardiovascular risk. |
| format | Article |
| id | doaj-art-49f5c6ce8ec548698463839a68511aca |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-49f5c6ce8ec548698463839a68511aca2025-02-03T01:10:33ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/378658378658Chlamydia pneumoniae-Mediated Inflammation in Atherosclerosis: A Meta-AnalysisSimone Filardo0Marisa Di Pietro1Alessio Farcomeni2Giovanna Schiavoni3Rosa Sessa4Section of Microbiology, Department of Public Health and Infectious Diseases, “Sapienza” University, Rome, ItalySection of Microbiology, Department of Public Health and Infectious Diseases, “Sapienza” University, Rome, ItalySection of Statistic, Department of Public Health and Infectious Diseases, “Sapienza” University, Rome, ItalySection of Microbiology, Department of Public Health and Infectious Diseases, “Sapienza” University, Rome, ItalySection of Microbiology, Department of Public Health and Infectious Diseases, “Sapienza” University, Rome, ItalySeveral studies have attempted to relate the C. pneumoniae-mediated inflammatory state with atherosclerotic cardiovascular diseases, providing inconsistent results. Therefore, we performed a meta-analysis to clarify whether C. pneumoniae may contribute to the pathogenesis of atherosclerosis by enhancing inflammation. 12 case-control, 6 cross-sectional, and 7 prospective studies with a total of 10,176 patients have been included in this meta-analysis. Odds Ratio (OR) with a 95% confidence interval was used to assess the seroprevalence of C. pneumoniae and differences between levels of inflammatory markers were assessed by standard mean differences. Publication bias was performed to ensure the statistical power. hsCRP, fibrinogen, interleukin- (IL-) 6, TNF-α, and IFN-γ showed a significant increase in patients with atherosclerosis compared to healthy controls (P<0.05), along with a higher seroprevalence of C. pneumoniae (OR of 3.11, 95% CI: 2.88–3.36, P<0.001). More interestingly, hsCRP, IL-6, and fibrinogen levels were significantly higher in C. pneumoniae IgA seropositive compared to seronegative atherosclerotic patients (P<0.0001). In conclusion, the present meta-analysis suggests that C. pneumoniae infection may contribute to atherosclerotic cardiovascular diseases by enhancing the inflammatory state, and, in particular, seropositivity to C. pneumoniae IgA, together with hsCRP, fibrinogen, and IL-6, may be predictive of atherosclerotic cardiovascular risk.http://dx.doi.org/10.1155/2015/378658 |
| spellingShingle | Simone Filardo Marisa Di Pietro Alessio Farcomeni Giovanna Schiavoni Rosa Sessa Chlamydia pneumoniae-Mediated Inflammation in Atherosclerosis: A Meta-Analysis Mediators of Inflammation |
| title | Chlamydia pneumoniae-Mediated Inflammation in Atherosclerosis: A Meta-Analysis |
| title_full | Chlamydia pneumoniae-Mediated Inflammation in Atherosclerosis: A Meta-Analysis |
| title_fullStr | Chlamydia pneumoniae-Mediated Inflammation in Atherosclerosis: A Meta-Analysis |
| title_full_unstemmed | Chlamydia pneumoniae-Mediated Inflammation in Atherosclerosis: A Meta-Analysis |
| title_short | Chlamydia pneumoniae-Mediated Inflammation in Atherosclerosis: A Meta-Analysis |
| title_sort | chlamydia pneumoniae mediated inflammation in atherosclerosis a meta analysis |
| url | http://dx.doi.org/10.1155/2015/378658 |
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