Comparison of the Effectiveness of Three Methods of Recanalization in a Model of the Middle Cerebral Artery: Thrombus Aspiration via a 4F Catheter, Thrombus Aspiration via the GP Thromboaspiration Device, and Mechanical Thrombectomy Using the Solitaire Thrombectomy Device
Introduction. This paper compares different approaches to recanalization in a model of the middle cerebral artery (MCA). Methods. An occlusive thrombus (lamb's blood) was introduced into the MCA of a model of the cerebral circulation perfused with Hartmann's solution (80 pulsations/min, me...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | Stroke Research and Treatment |
| Online Access: | http://dx.doi.org/10.4061/2011/186424 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832567789051707392 |
|---|---|
| author | Christopher Tennuci Gillian Pearce Julian Wong Sanjeev Nayak Tom Jones Frank Lally Christine Roffe |
| author_facet | Christopher Tennuci Gillian Pearce Julian Wong Sanjeev Nayak Tom Jones Frank Lally Christine Roffe |
| author_sort | Christopher Tennuci |
| collection | DOAJ |
| description | Introduction. This paper compares different approaches to recanalization in a model of the middle cerebral artery (MCA). Methods. An occlusive thrombus (lamb's blood) was introduced into the MCA of a model of the cerebral circulation perfused with Hartmann's solution (80 pulsations/min, mean pressure 90 mm Hg). Three methods of clot retrieval were tested: thrombus aspiration via a 4F catheter (n=26), thrombus aspiration via the GP thrombus aspiration device (GPTAD) (n=30), and mechanical thrombectomy via the Solitaire Device (n=30). Results. Recanalization rate was similar for all 3 approaches (62%, 77%, and 85%). Time to recanalization was faster with aspiration devices (41 SD 42 s for 4F and 61 SD 21 s for GPTAD) than with the Solitaire (197 SD 64 s P<.05 Kruksal-Wallis). Clot fragmentation was the same in the Solitaire (23%) and the GPTAD (23%), but higher with the 4F (53%, P<.05). Conclusion. In this model, thrombus aspiration was faster than mechanical thrombectomy, and similarly effective at recanalization. These results should be confirmed in vivo. |
| format | Article |
| id | doaj-art-49ba38c1ce424ae786ccc62b38dd8c02 |
| institution | Kabale University |
| issn | 2042-0056 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke Research and Treatment |
| spelling | doaj-art-49ba38c1ce424ae786ccc62b38dd8c022025-02-03T01:00:34ZengWileyStroke Research and Treatment2042-00562011-01-01201110.4061/2011/186424186424Comparison of the Effectiveness of Three Methods of Recanalization in a Model of the Middle Cerebral Artery: Thrombus Aspiration via a 4F Catheter, Thrombus Aspiration via the GP Thromboaspiration Device, and Mechanical Thrombectomy Using the Solitaire Thrombectomy DeviceChristopher Tennuci0Gillian Pearce1Julian Wong2Sanjeev Nayak3Tom Jones4Frank Lally5Christine Roffe6School of Medicine, Keele University, Staffordshire ST5 5BG, UKBiomedical Science Division, University of Wolverhampton, Wolverhampton WV1 1LY, UKDepartment of Vascular Surgery, University Hospital of North Staffordshire, Newcastle Road, Staffordshire ST4 6QG, UKStroke Research Offices, North Staffordshire Royal Infirmary, Princes Road, Stoke-on-Trent, Staffordshire ST4 7LN, UKSchool of Medicine, Keele University, Staffordshire ST5 5BG, UKInstitute for Science and Technology in Medicine, Keele University, Keele, Staffordshire ST6 6TP, UKInstitute for Science and Technology in Medicine, Keele University, Keele, Staffordshire ST6 6TP, UKIntroduction. This paper compares different approaches to recanalization in a model of the middle cerebral artery (MCA). Methods. An occlusive thrombus (lamb's blood) was introduced into the MCA of a model of the cerebral circulation perfused with Hartmann's solution (80 pulsations/min, mean pressure 90 mm Hg). Three methods of clot retrieval were tested: thrombus aspiration via a 4F catheter (n=26), thrombus aspiration via the GP thrombus aspiration device (GPTAD) (n=30), and mechanical thrombectomy via the Solitaire Device (n=30). Results. Recanalization rate was similar for all 3 approaches (62%, 77%, and 85%). Time to recanalization was faster with aspiration devices (41 SD 42 s for 4F and 61 SD 21 s for GPTAD) than with the Solitaire (197 SD 64 s P<.05 Kruksal-Wallis). Clot fragmentation was the same in the Solitaire (23%) and the GPTAD (23%), but higher with the 4F (53%, P<.05). Conclusion. In this model, thrombus aspiration was faster than mechanical thrombectomy, and similarly effective at recanalization. These results should be confirmed in vivo.http://dx.doi.org/10.4061/2011/186424 |
| spellingShingle | Christopher Tennuci Gillian Pearce Julian Wong Sanjeev Nayak Tom Jones Frank Lally Christine Roffe Comparison of the Effectiveness of Three Methods of Recanalization in a Model of the Middle Cerebral Artery: Thrombus Aspiration via a 4F Catheter, Thrombus Aspiration via the GP Thromboaspiration Device, and Mechanical Thrombectomy Using the Solitaire Thrombectomy Device Stroke Research and Treatment |
| title | Comparison of the Effectiveness of Three Methods of Recanalization in a Model of the Middle Cerebral Artery: Thrombus Aspiration via a 4F Catheter, Thrombus Aspiration via the GP Thromboaspiration Device, and Mechanical Thrombectomy Using the Solitaire Thrombectomy Device |
| title_full | Comparison of the Effectiveness of Three Methods of Recanalization in a Model of the Middle Cerebral Artery: Thrombus Aspiration via a 4F Catheter, Thrombus Aspiration via the GP Thromboaspiration Device, and Mechanical Thrombectomy Using the Solitaire Thrombectomy Device |
| title_fullStr | Comparison of the Effectiveness of Three Methods of Recanalization in a Model of the Middle Cerebral Artery: Thrombus Aspiration via a 4F Catheter, Thrombus Aspiration via the GP Thromboaspiration Device, and Mechanical Thrombectomy Using the Solitaire Thrombectomy Device |
| title_full_unstemmed | Comparison of the Effectiveness of Three Methods of Recanalization in a Model of the Middle Cerebral Artery: Thrombus Aspiration via a 4F Catheter, Thrombus Aspiration via the GP Thromboaspiration Device, and Mechanical Thrombectomy Using the Solitaire Thrombectomy Device |
| title_short | Comparison of the Effectiveness of Three Methods of Recanalization in a Model of the Middle Cerebral Artery: Thrombus Aspiration via a 4F Catheter, Thrombus Aspiration via the GP Thromboaspiration Device, and Mechanical Thrombectomy Using the Solitaire Thrombectomy Device |
| title_sort | comparison of the effectiveness of three methods of recanalization in a model of the middle cerebral artery thrombus aspiration via a 4f catheter thrombus aspiration via the gp thromboaspiration device and mechanical thrombectomy using the solitaire thrombectomy device |
| url | http://dx.doi.org/10.4061/2011/186424 |
| work_keys_str_mv | AT christophertennuci comparisonoftheeffectivenessofthreemethodsofrecanalizationinamodelofthemiddlecerebralarterythrombusaspirationviaa4fcatheterthrombusaspirationviathegpthromboaspirationdeviceandmechanicalthrombectomyusingthesolitairethrombectomydevice AT gillianpearce comparisonoftheeffectivenessofthreemethodsofrecanalizationinamodelofthemiddlecerebralarterythrombusaspirationviaa4fcatheterthrombusaspirationviathegpthromboaspirationdeviceandmechanicalthrombectomyusingthesolitairethrombectomydevice AT julianwong comparisonoftheeffectivenessofthreemethodsofrecanalizationinamodelofthemiddlecerebralarterythrombusaspirationviaa4fcatheterthrombusaspirationviathegpthromboaspirationdeviceandmechanicalthrombectomyusingthesolitairethrombectomydevice AT sanjeevnayak comparisonoftheeffectivenessofthreemethodsofrecanalizationinamodelofthemiddlecerebralarterythrombusaspirationviaa4fcatheterthrombusaspirationviathegpthromboaspirationdeviceandmechanicalthrombectomyusingthesolitairethrombectomydevice AT tomjones comparisonoftheeffectivenessofthreemethodsofrecanalizationinamodelofthemiddlecerebralarterythrombusaspirationviaa4fcatheterthrombusaspirationviathegpthromboaspirationdeviceandmechanicalthrombectomyusingthesolitairethrombectomydevice AT franklally comparisonoftheeffectivenessofthreemethodsofrecanalizationinamodelofthemiddlecerebralarterythrombusaspirationviaa4fcatheterthrombusaspirationviathegpthromboaspirationdeviceandmechanicalthrombectomyusingthesolitairethrombectomydevice AT christineroffe comparisonoftheeffectivenessofthreemethodsofrecanalizationinamodelofthemiddlecerebralarterythrombusaspirationviaa4fcatheterthrombusaspirationviathegpthromboaspirationdeviceandmechanicalthrombectomyusingthesolitairethrombectomydevice |