Anti Epileptic Activity of Morinda citrifolia Linn Fruit Extract
Fruit extract of Morinda citrifolia (Noni), a medicinal plant used in many neuro protective ayurvedic preparations was evaluated for its protective effect against seizures induced by Maximal Electro Shock (MES) method in rats. A daily dose of 200 and 400 mg/kg of the extract was administered to the...
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Wiley
2010-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2010/795804 |
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| author | P. Muralidharan J. Srikanth |
| author_facet | P. Muralidharan J. Srikanth |
| author_sort | P. Muralidharan |
| collection | DOAJ |
| description | Fruit extract of Morinda citrifolia (Noni), a medicinal plant used in many neuro protective ayurvedic preparations was evaluated for its protective effect against seizures induced by Maximal Electro Shock (MES) method in rats. A daily dose of 200 and 400 mg/kg of the extract was administered to the animals for 15 days, after which seizures were induced by maximum electro shock method and the duration of various phases of epileptic attacks were recorded and compared with the control animals. A significant (P<0.01 and P<0.001) reduction in the time taken for righting reflex (recovery) was noted in the experimental animals. The levels of biogenic amines such as dopamine, serotonin and nor-adrenaline in the forebrain region were also estimated and a significant level of restoration was opserved in the extract treated animals. Significant results were opserved in the estimated parameters thereby justifying the use of this medicinal plant in the treatment of epilepsy. |
| format | Article |
| id | doaj-art-49b9018ed2b64a5bae64cfc42c28b6f4 |
| institution | DOAJ |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
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| series | E-Journal of Chemistry |
| spelling | doaj-art-49b9018ed2b64a5bae64cfc42c28b6f42025-08-20T02:39:22ZengWileyE-Journal of Chemistry0973-49452090-98102010-01-017261261610.1155/2010/795804Anti Epileptic Activity of Morinda citrifolia Linn Fruit ExtractP. Muralidharan0J. Srikanth1Department of Pharmacology and Toxicology, C.L.Baid Metha College of Pharmacy, Jyothi Nager, Thoraippakkam, Chennai-600 097. Tamilnadu, IndiaDepartment of Pharmacology, Sri Ramachandra College of Pharmacy, Sri Ramachandra University, Porur, Chennai-600116, Tamilnadu, IndiaFruit extract of Morinda citrifolia (Noni), a medicinal plant used in many neuro protective ayurvedic preparations was evaluated for its protective effect against seizures induced by Maximal Electro Shock (MES) method in rats. A daily dose of 200 and 400 mg/kg of the extract was administered to the animals for 15 days, after which seizures were induced by maximum electro shock method and the duration of various phases of epileptic attacks were recorded and compared with the control animals. A significant (P<0.01 and P<0.001) reduction in the time taken for righting reflex (recovery) was noted in the experimental animals. The levels of biogenic amines such as dopamine, serotonin and nor-adrenaline in the forebrain region were also estimated and a significant level of restoration was opserved in the extract treated animals. Significant results were opserved in the estimated parameters thereby justifying the use of this medicinal plant in the treatment of epilepsy.http://dx.doi.org/10.1155/2010/795804 |
| spellingShingle | P. Muralidharan J. Srikanth Anti Epileptic Activity of Morinda citrifolia Linn Fruit Extract E-Journal of Chemistry |
| title | Anti Epileptic Activity of Morinda citrifolia Linn Fruit Extract |
| title_full | Anti Epileptic Activity of Morinda citrifolia Linn Fruit Extract |
| title_fullStr | Anti Epileptic Activity of Morinda citrifolia Linn Fruit Extract |
| title_full_unstemmed | Anti Epileptic Activity of Morinda citrifolia Linn Fruit Extract |
| title_short | Anti Epileptic Activity of Morinda citrifolia Linn Fruit Extract |
| title_sort | anti epileptic activity of morinda citrifolia linn fruit extract |
| url | http://dx.doi.org/10.1155/2010/795804 |
| work_keys_str_mv | AT pmuralidharan antiepilepticactivityofmorindacitrifolialinnfruitextract AT jsrikanth antiepilepticactivityofmorindacitrifolialinnfruitextract |