Anti-HEV antibody reactivity rate in voluntary blood donors in China: a Meta-analysis
[Objective] To explore the relationship between anti-HEV antibody reactivity rate and different age groups in Chinese voluntary blood donors by Meta-analysis. [Methods] Literatures on anti-HEV IgG reactivity rate and anti-HEV IgM reactivity rate of voluntary blood donors in different age groups in C...
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Institute of Blood Transfusion of Chinese Academy of Medical Sciences
2025-01-01
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| Series: | Zhongguo shuxue zazhi |
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| Online Access: | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.01.005&lang=en |
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| author | XU Niuniu JIAO Zhanying |
| author_facet | XU Niuniu JIAO Zhanying |
| author_sort | XU Niuniu |
| collection | DOAJ |
| description | [Objective] To explore the relationship between anti-HEV antibody reactivity rate and different age groups in Chinese voluntary blood donors by Meta-analysis. [Methods] Literatures on anti-HEV IgG reactivity rate and anti-HEV IgM reactivity rate of voluntary blood donors in different age groups in China were searched from China National Knowledge Infrastructure (CNKI), PubMed and Wanfang Medicine database, with a search time from January 1, 2007 to December 31, 2023. Risk difference (RD) was selected as the effect size after grouping the included literature according to age, and meta-analysis was performed using Review Manager 5.3 software. [Results] A total of 17 articles were included, among which 16 were about anti-HEV IgG and 15 about anti-HEV IgM. Based on different age grouping methods, they were divided into two groups. The age groups of group A were divided into ≤ 20 years old, 21-30 years old, 31-40 years old, 41-50 years old and >50 years old. The age groups of group B were divided into 18-25 years old, 26-35 years old, 36-45 years old, and ≥46 years old. The pooled results of Meta-analysis showed that the RD value of anti-HEV IgG reactivity rate in group A was 22.92% [95% CI (19.02%, 26.82%)], and the RD value of anti-HEV IgM reactivity rate was 0.67% [95% CI (0.51%, 0.82%)]. The RD value of anti-HEV IgG reactivity rate in group B was 33.03% [95% CI (28.01%, 38.05%)], and the RD value of anti-HEV IgM reactivity rate was 1.13% [95% CI (1.05%, 1.21%)]. The results of subgroup analysis showed that in both group A and B, the anti-HEV IgG reactivity rate in voluntary blood donors increased with age. In group A, no increase in the reactivity rate of anti-HEV IgM with age was found in voluntary blood donors. In group B, the anti-HEV IgM reactivity rate increased with age. Further analysis showed that in the two groups of A and B, the anti-HEV IgM reactivity rate increased with age in areas where the anti-HEV IgM reactivity rate was greater than 1%. [Conclusion] The anti-HEV IgG reactivity rate and anti-HEV IgM reactivity rate in voluntary blood donors increased with age. |
| format | Article |
| id | doaj-art-49adca9569694ae5b6a49c040fd61b37 |
| institution | Kabale University |
| issn | 1004-549X |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | Institute of Blood Transfusion of Chinese Academy of Medical Sciences |
| record_format | Article |
| series | Zhongguo shuxue zazhi |
| spelling | doaj-art-49adca9569694ae5b6a49c040fd61b372025-01-27T01:46:11ZzhoInstitute of Blood Transfusion of Chinese Academy of Medical SciencesZhongguo shuxue zazhi1004-549X2025-01-01381263710.13303/j.cjbt.issn.1004-549x.2025.01.0051004-549X(2025)1-0026-12Anti-HEV antibody reactivity rate in voluntary blood donors in China: a Meta-analysisXU Niuniu0JIAO Zhanying1Wuhan Blood Center, Wuhan 430030, ChinaDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China[Objective] To explore the relationship between anti-HEV antibody reactivity rate and different age groups in Chinese voluntary blood donors by Meta-analysis. [Methods] Literatures on anti-HEV IgG reactivity rate and anti-HEV IgM reactivity rate of voluntary blood donors in different age groups in China were searched from China National Knowledge Infrastructure (CNKI), PubMed and Wanfang Medicine database, with a search time from January 1, 2007 to December 31, 2023. Risk difference (RD) was selected as the effect size after grouping the included literature according to age, and meta-analysis was performed using Review Manager 5.3 software. [Results] A total of 17 articles were included, among which 16 were about anti-HEV IgG and 15 about anti-HEV IgM. Based on different age grouping methods, they were divided into two groups. The age groups of group A were divided into ≤ 20 years old, 21-30 years old, 31-40 years old, 41-50 years old and >50 years old. The age groups of group B were divided into 18-25 years old, 26-35 years old, 36-45 years old, and ≥46 years old. The pooled results of Meta-analysis showed that the RD value of anti-HEV IgG reactivity rate in group A was 22.92% [95% CI (19.02%, 26.82%)], and the RD value of anti-HEV IgM reactivity rate was 0.67% [95% CI (0.51%, 0.82%)]. The RD value of anti-HEV IgG reactivity rate in group B was 33.03% [95% CI (28.01%, 38.05%)], and the RD value of anti-HEV IgM reactivity rate was 1.13% [95% CI (1.05%, 1.21%)]. The results of subgroup analysis showed that in both group A and B, the anti-HEV IgG reactivity rate in voluntary blood donors increased with age. In group A, no increase in the reactivity rate of anti-HEV IgM with age was found in voluntary blood donors. In group B, the anti-HEV IgM reactivity rate increased with age. Further analysis showed that in the two groups of A and B, the anti-HEV IgM reactivity rate increased with age in areas where the anti-HEV IgM reactivity rate was greater than 1%. [Conclusion] The anti-HEV IgG reactivity rate and anti-HEV IgM reactivity rate in voluntary blood donors increased with age.https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.01.005&lang=enhepatitis e virusblood screeningmeta-analysisblood transmissiontransfusion safety |
| spellingShingle | XU Niuniu JIAO Zhanying Anti-HEV antibody reactivity rate in voluntary blood donors in China: a Meta-analysis Zhongguo shuxue zazhi hepatitis e virus blood screening meta-analysis blood transmission transfusion safety |
| title | Anti-HEV antibody reactivity rate in voluntary blood donors in China: a Meta-analysis |
| title_full | Anti-HEV antibody reactivity rate in voluntary blood donors in China: a Meta-analysis |
| title_fullStr | Anti-HEV antibody reactivity rate in voluntary blood donors in China: a Meta-analysis |
| title_full_unstemmed | Anti-HEV antibody reactivity rate in voluntary blood donors in China: a Meta-analysis |
| title_short | Anti-HEV antibody reactivity rate in voluntary blood donors in China: a Meta-analysis |
| title_sort | anti hev antibody reactivity rate in voluntary blood donors in china a meta analysis |
| topic | hepatitis e virus blood screening meta-analysis blood transmission transfusion safety |
| url | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.01.005&lang=en |
| work_keys_str_mv | AT xuniuniu antihevantibodyreactivityrateinvoluntaryblooddonorsinchinaametaanalysis AT jiaozhanying antihevantibodyreactivityrateinvoluntaryblooddonorsinchinaametaanalysis |