Whole Blood Metabolomic Profiling of Mice with Tacrolimus-Induced Chronic Nephrotoxicity: NAD<sup>+</sup> Depletion with Salvage Pathway Impairment

Whole Blood Metabolomic Profiling of Mice with Tacrolimus-Induced Chronic Nephrotoxicity: NAD<sup>+</sup> Depletion with Salvage Pathway Impairment

Tacrolimus (TAC)-induced chronic nephrotoxicity (TAC nephrotoxicity) is a serious issue for long-term graft survival in kidney transplantation. However, the pathophysiology of TAC nephrotoxicity remains unclear. In this study, we analyzed whole blood samples from mice that developed TAC nephrotoxici...

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Bibliographic Details
Main Authors: Sho Nishida, Tamaki Ishima, Daiki Iwami, Ryozo Nagai, Kenichi Aizawa
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Antioxidants
Subjects:
tacrolimus (TAC)
TAC nephrotoxicity
NAD<sup>+</sup>
metabolomics
chronic kidney disease biomarkers
ADMA
Online Access:https://www.mdpi.com/2076-3921/14/1/62
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