Novel Insights for Systemic Inflammation in Sepsis and Hemorrhage
The inflammatory responses in sepsis and hemorrhage remain a major cause of death. Clinically, it is generally accepted that shock in sepsis or hemorrhage differs in its mechanisms. However, the recognition of inflammatory cytokines as a common lethal pathway has become consent. Proinflammatory cyto...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2010/642462 |
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| author | Bolin Cai Edwin A. Deitch Luis Ulloa |
| author_facet | Bolin Cai Edwin A. Deitch Luis Ulloa |
| author_sort | Bolin Cai |
| collection | DOAJ |
| description | The inflammatory responses in sepsis and hemorrhage remain a major cause of death. Clinically, it is generally accepted that shock in sepsis or hemorrhage differs in its mechanisms. However, the recognition of inflammatory cytokines as a common lethal pathway has become consent. Proinflammatory cytokines such as tumor necrosis factor (TNF) or high-mobility group box1 (HMGB1) are fanatically released and cause lethal multiorgan dysfunction. Inhibition of these cytokines can prevent the inflammatory responses and organ damage. In seeking potential anti-inflammatory strategies, we reported that ethyl pyruvate and alpha7 nicotinic acetylcholine receptor (alpha7nAChR) agonists effectively restrained cytokine production to provide therapeutic benefits in both experimental sepsis and hemorrhage. Here, we review the inflammatory responses and the anti-inflammatory strategies in experimental models of sepsis and hemorrhage, as they may have a consistent inflammatory pathway in spite of their different pathophysiological processes. |
| format | Article |
| id | doaj-art-499504f5bce14b8b94815a4e3977a64b |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-499504f5bce14b8b94815a4e3977a64b2025-02-03T06:11:03ZengWileyMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/642462642462Novel Insights for Systemic Inflammation in Sepsis and HemorrhageBolin Cai0Edwin A. Deitch1Luis Ulloa2Laboratory of Anti-Inflammatory Signaling and Surgical Immunology, Department of Surgery, UMDNJ-New Jersey Medical School, Medical Science Building F-673, 185 South Orange Avenue, P.O. Box 1709, Newark, NJ 07103, USALaboratory of Anti-Inflammatory Signaling and Surgical Immunology, Department of Surgery, UMDNJ-New Jersey Medical School, Medical Science Building F-673, 185 South Orange Avenue, P.O. Box 1709, Newark, NJ 07103, USALaboratory of Anti-Inflammatory Signaling and Surgical Immunology, Department of Surgery, UMDNJ-New Jersey Medical School, Medical Science Building F-673, 185 South Orange Avenue, P.O. Box 1709, Newark, NJ 07103, USAThe inflammatory responses in sepsis and hemorrhage remain a major cause of death. Clinically, it is generally accepted that shock in sepsis or hemorrhage differs in its mechanisms. However, the recognition of inflammatory cytokines as a common lethal pathway has become consent. Proinflammatory cytokines such as tumor necrosis factor (TNF) or high-mobility group box1 (HMGB1) are fanatically released and cause lethal multiorgan dysfunction. Inhibition of these cytokines can prevent the inflammatory responses and organ damage. In seeking potential anti-inflammatory strategies, we reported that ethyl pyruvate and alpha7 nicotinic acetylcholine receptor (alpha7nAChR) agonists effectively restrained cytokine production to provide therapeutic benefits in both experimental sepsis and hemorrhage. Here, we review the inflammatory responses and the anti-inflammatory strategies in experimental models of sepsis and hemorrhage, as they may have a consistent inflammatory pathway in spite of their different pathophysiological processes.http://dx.doi.org/10.1155/2010/642462 |
| spellingShingle | Bolin Cai Edwin A. Deitch Luis Ulloa Novel Insights for Systemic Inflammation in Sepsis and Hemorrhage Mediators of Inflammation |
| title | Novel Insights for Systemic Inflammation in Sepsis and Hemorrhage |
| title_full | Novel Insights for Systemic Inflammation in Sepsis and Hemorrhage |
| title_fullStr | Novel Insights for Systemic Inflammation in Sepsis and Hemorrhage |
| title_full_unstemmed | Novel Insights for Systemic Inflammation in Sepsis and Hemorrhage |
| title_short | Novel Insights for Systemic Inflammation in Sepsis and Hemorrhage |
| title_sort | novel insights for systemic inflammation in sepsis and hemorrhage |
| url | http://dx.doi.org/10.1155/2010/642462 |
| work_keys_str_mv | AT bolincai novelinsightsforsystemicinflammationinsepsisandhemorrhage AT edwinadeitch novelinsightsforsystemicinflammationinsepsisandhemorrhage AT luisulloa novelinsightsforsystemicinflammationinsepsisandhemorrhage |